PDB: 287 resultsInfo pagesStatus searchChemie searchBIRD

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7LEQ	Structure of importin a2 bound to p50 NLS Descriptor: Importin subunit alpha-1, Nuclear factor NF-kappa-B p105 subunit Authors: Florio, T.J, Lokareddy, R.K, Cingolani, G. Deposit date: 2021-01-14 Release date: 2022-01-19 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.24 Å) Cite: Differential recognition of canonical NF-kappa B dimers by Importin alpha 3. Nat Commun, 13, 2022
7LET	Structure of importin a2 bound to the p50- and p65-NLSs Descriptor: Importin subunit alpha-1, Nuclear factor NF-kappa-B p105 subunit, Transcription factor p65 Authors: Florio, T.J, Lokareddy, R.K, Cingolani, G. Deposit date: 2021-01-15 Release date: 2022-01-19 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Differential recognition of canonical NF-kappa B dimers by Importin alpha 3. Nat Commun, 13, 2022
7LF4	Structure of importin a3 bound to the p50- and p65-NLSs Descriptor: Importin subunit alpha-3, Nuclear factor NF-kappa-B p105 subunit, Transcription factor p65 Authors: Florio, T.J, Lokareddy, R.K, Cingolani, G. Deposit date: 2021-01-15 Release date: 2022-01-19 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Differential recognition of canonical NF-kappa B dimers by Importin alpha 3. Nat Commun, 13, 2022
7M60	Structure of Mouse Importin alpha MLH1-S467A NLS Peptide Complex Descriptor: DNA mismatch repair protein Mlh1 NLS peptide, Importin subunit alpha-1 Authors: De Oliveira, H.C, Da Silva, T.D, Fukuda, C.A, Fontes, M.R.M. Deposit date: 2021-03-25 Release date: 2021-07-07 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural and calorimetric studies reveal specific determinants for the binding of a high-affinity NLS to mammalian importin-alpha. Biochem.J., 478, 2021
5X8N	Crystal structure of mouse importin-alpha1 bound to the nuclear localization signal of Epstein-Barr virus EBNA-LP protein Descriptor: Epstein-Barr nuclear antigen leader protein, Importin subunit alpha-1 Authors: Nakada, R, Matsuura, Y. Deposit date: 2017-03-03 Release date: 2017-04-19 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Crystal structure of importin-alpha bound to the nuclear localization signal of Epstein-Barr virus EBNA-LP protein Protein Sci., 26, 2017
5XZX	Crystal structure of importin-alpha3 bound to the nuclear localization signal of Ran-binding protein 3 Descriptor: Importin subunit alpha-3, Ran-binding protein 3 Authors: Koyama, M, Matsuura, Y. Deposit date: 2017-07-14 Release date: 2017-08-09 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3 Å) Cite: Crystal structure of importin-alpha 3 bound to the nuclear localization signal of Ran-binding protein 3 Biochem. Biophys. Res. Commun., 491, 2017
5Z8H	APC with an inhibitor Descriptor: Adenomatous polyposis coli protein, GLYCEROL, Peptide inhibitor Authors: Zhang, J, Yang, X.Y, Song, K. Deposit date: 2018-01-31 Release date: 2019-02-06 Method: X-RAY DIFFRACTION (1.79 Å) Cite: APC with an inhibitor To Be Published
6BVZ	Importin alpha 3 in cargo free state Descriptor: Importin subunit alpha-3 Authors: Smith, K.M, Tsimbalyuk, S, Edwards, M.R, Aragao, D, Cross, E.M, Basler, C.F, Forwood, J.K. Deposit date: 2017-12-14 Release date: 2018-07-04 Last modified: 2023-03-29 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses. Nat Commun, 9, 2018
6BW9	Hendra virus W protein C-terminus in complex with Importin alpha 3 crystal form 1 Descriptor: Importin subunit alpha-3, Protein W Authors: Tsimbalyuk, S, Smith, K.M, Edwards, M.R, Aragao, D, Cross, E.M, Basler, C.F, Forwood, J.K. Deposit date: 2017-12-14 Release date: 2018-07-04 Last modified: 2023-03-29 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses. Nat Commun, 9, 2018
6BWA	Hendra virus W protein C-terminus in complex with Importin alpha 3 crystal form 2 Descriptor: Importin subunit alpha-3, Protein W Authors: Tsimbalyuk, S, Smith, K.M, Edwards, M.R, Aragao, D, Cross, E.M, Basler, C.F, Forwood, J.K. Deposit date: 2017-12-14 Release date: 2018-07-04 Last modified: 2023-03-29 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses. Nat Commun, 9, 2018
6BVT	Importin alpha 1 in cargo free state Descriptor: Importin subunit alpha-1 Authors: Smith, K.M, Tsimablyuk, S, Edwards, M.R, Aragao, D, Cross, E.M, Basler, C.F, Forwood, J.K. Deposit date: 2017-12-13 Release date: 2018-07-04 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses. Nat Commun, 9, 2018
6BW0	Nipah virus W protein C-terminus in complex with Importin alpha 1 Descriptor: Importin subunit alpha-1, Protein W Authors: Smith, K.M, Tsimbalyuk, S, Edwards, M.R, Aragao, D, Cross, E.M, Basler, C.F, Forwood, J.K. Deposit date: 2017-12-14 Release date: 2018-07-04 Last modified: 2023-03-29 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses. Nat Commun, 9, 2018
6BWB	Hendra virus W protein C-terminus in complex with Importin alpha 3 crystal form 3 Descriptor: Importin subunit alpha-3, Protein W Authors: Tsimbalyuk, S, Smith, K.M, Edwards, M.R, Aragao, D, Cross, E.M, Basler, C.F, Forwood, J.K. Deposit date: 2017-12-14 Release date: 2018-07-04 Last modified: 2023-03-29 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses. Nat Commun, 9, 2018
6BW1	Hendra virus W protein C-terminus in complex with Importin alpha 1 Descriptor: Importin subunit alpha-1, Protein W Authors: Tsimbalyuk, S, Smith, K.M, Edwards, M.R, Aragao, D, Cross, E.M, Basler, C.F, Forwood, J.K. Deposit date: 2017-12-14 Release date: 2018-07-04 Last modified: 2023-03-29 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses. Nat Commun, 9, 2018
6BVV	Nipah virus W protein C-terminus in complex with Importin alpha 3 Descriptor: Importin subunit alpha-3, Protein W Authors: Smith, K.M, Tsimbalyuk, S, Edwards, M.R, Aragao, D, Cross, E.M, Basler, C.F, Forwood, J.K. Deposit date: 2017-12-13 Release date: 2018-07-04 Last modified: 2023-03-29 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses. Nat Commun, 9, 2018
5SVZ	HIV-1 Tat NLS in complex with importin alpha Descriptor: Importin subunit alpha-1, Tat Authors: Smith, K.M, Himiari, Z, Forwood, J.K. Deposit date: 2016-08-08 Release date: 2016-08-31 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural Basis for Importin-alpha Binding of the Human Immunodeficiency Virus Tat. Sci Rep, 7, 2017
5U5R	Crystal Structure and X-ray Diffraction Data Collection of Importin-alpha from Mus musculus Complexed with a PMS2 NLS Peptide Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Importin subunit alpha-1, Mismatch repair endonuclease PMS2 Authors: Barros, A.C, Takeda, A.A, Dreyer, T.R, Velazquez-Campoy, A, Kobe, B, Fontes, M.R. Deposit date: 2016-12-07 Release date: 2018-03-14 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.1 Å) Cite: DNA mismatch repair proteins MLH1 and PMS2 can be imported to the nucleus by a classical nuclear import pathway. Biochimie, 146, 2018
5U5P	Crystal Structure and X-ray Diffraction Data Collection of Importin-alpha from Mus Musculus Complexed with a MLH1 NLS Peptide Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, DNA mismatch repair protein Mlh1, Importin subunit alpha-1 Authors: Barros, A.C, Takeda, A.A, Dreyer, T.R, Velazquez-Campoy, A, Kobe, B, Fontes, M.R. Deposit date: 2016-12-07 Release date: 2018-03-14 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.171 Å) Cite: DNA mismatch repair proteins MLH1 and PMS2 can be imported to the nucleus by a classical nuclear import pathway. Biochimie, 146, 2018
5V5P	Structure of NLS2R of influenza A virus nucleoprotein bound to importin alpha Descriptor: Importin subunit alpha-1, Nucleoprotein Authors: Sankhala, R.S, Lokareddy, R.K, Cingolani, G. Deposit date: 2017-03-14 Release date: 2018-03-14 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Synergy of two low-affinity NLSs determines the high avidity of influenza A virus nucleoprotein NP for human importin alpha isoforms. Sci Rep, 7, 2017
5UMZ	Structure of TNRC6A NLS in complex with importin-alpha Descriptor: GLYCEROL, Importin subunit alpha-1, TNRC6A Authors: Chaston, J, Stewart, A.G, Christie, M. Deposit date: 2017-01-30 Release date: 2017-12-27 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural characterisation of TNRC6A nuclear localisation signal in complex with importin-alpha. PLoS ONE, 12, 2017
5V5O	Structure of NLS2K of influenza A virus nucleoprotein bound to importin alpha Descriptor: Importin subunit alpha-1, Nucleoprotein Authors: Sankhala, R.S, Lokareddy, R.K, Cingolani, G. Deposit date: 2017-03-14 Release date: 2018-03-14 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.243 Å) Cite: Synergy of two low-affinity NLSs determines the high avidity of influenza A virus nucleoprotein NP for human importin alpha isoforms. Sci Rep, 7, 2017
5VQI	Nuclear transport of the Neurospora crassa NIT2 transcription factor is mediated by Importin-alpha Descriptor: Importin subunit alpha, Nuclear localization sequence of NIT2 transcription factor (NIT2-NLS) Authors: Bernardes, N.E, Fontes, M.R.M. Deposit date: 2017-05-09 Release date: 2017-11-01 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.501 Å) Cite: Nuclear transport of the Neurospora crassa NIT-2 transcription factor is mediated by importin-alpha. Biochem. J., 474, 2017
5W4G	Importin binding to NLS peptide of DNA polymerase lambda Descriptor: DNA polymerase lambda, GLYCEROL, Importin subunit alpha-1, ... Authors: Pedersen, L.C, London, R.E. Deposit date: 2017-06-10 Release date: 2018-06-13 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.038 Å) Cite: Structure of Importin with bound NLS from DNA polymerase lambda To Be Published
5W4F	Importin binding to pol Mu NLS peptide Descriptor: DNA-directed DNA/RNA polymerase mu, GLYCEROL, Importin subunit alpha-1 Authors: Pedersen, L.C, London, R.E. Deposit date: 2017-06-10 Release date: 2018-06-13 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.984 Å) Cite: Variations in nuclear localization strategies among pol X family enzymes. Traffic, 2018
5W41	Zika MR766 NLS in complex with Importin alpha subunit-1 Descriptor: Importin subunit alpha-1, ZIKA MR766 NLS Authors: Jeffress, S, Smith, K.M, Forwood, J.K. Deposit date: 2017-06-08 Release date: 2018-06-13 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Zika virus NS5 forms supramolecular nuclear bodies that sequester importin alpha and modulate the host immune and pro-inflammatory response in neuronal cells. ACS Infect Dis, 2019

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