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4U5W	Crystal Structure of HIV-1 Nef-SF2 Core Domain in Complex with the Src Family Kinase Hck SH3-SH2 Tandem Regulatory Domains Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, IODIDE ION, Protein Nef, ... Authors: Alvarado, J.J, Yeh, J.I, Smithgall, T.E. Deposit date: 2014-07-25 Release date: 2014-08-20 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Interaction with the Src Homology (SH3-SH2) Region of the Src-family Kinase Hck Structures the HIV-1 Nef Dimer for Kinase Activation and Effector Recruitment. J.Biol.Chem., 289, 2014
4ORZ	HIV-1 Nef protein in complex with single domain antibody sdAb19 and an engineered Hck SH3 domain Descriptor: Protein Nef, Tyrosine-protein kinase HCK, single domain antibody sdAb19 Authors: Geyer, M, Lulf, S. Deposit date: 2014-02-12 Release date: 2014-03-26 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibody. Retrovirology, 11, 2014
4NEE	crystal structure of AP-2 alpha/simga2 complex bound to HIV-1 Nef Descriptor: AP-2 complex subunit alpha-2, AP-2 complex subunit sigma, Protein Nef Authors: Hurley, J.H, Bonifacino, J.S, Ren, X, Park, S.Y. Deposit date: 2013-10-29 Release date: 2014-01-29 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.8841 Å) Cite: How HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4. Elife, 3, 2014
4EN2	HIV-1 Nef in complex with MHC-I cytoplasmic domain and Mu1 adaptin subunit of AP1 adaptor (second domain) Descriptor: AP-1 complex subunit mu-1, MHC-I, Protein Nef Authors: Jia, X, Xiong, Y. Deposit date: 2012-04-12 Release date: 2012-06-20 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.58 Å) Cite: Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef. Nat.Struct.Mol.Biol., 19, 2012
4EMZ	HIV-1 Nef in complex with MHC-I cytoplasmic domain and Mu1 adaptin subunit of AP1 adaptor (second domain) Descriptor: AP-1 complex subunit mu-1, MHC-I, Protein Nef Authors: Jia, X, Xiong, Y. Deposit date: 2012-04-12 Release date: 2012-06-20 Last modified: 2012-07-25 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef. Nat.Struct.Mol.Biol., 19, 2012
4D8D	Crystal structure of HIV-1 NEF Fyn-SH3 R96W variant Descriptor: GLYCEROL, Protein Nef, Tyrosine-protein kinase Fyn Authors: Arold, S.T, Hoh, F, Dumas, C. Deposit date: 2012-01-10 Release date: 2013-01-16 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.5201 Å) Cite: Synergy and allostery in ligand binding by HIV-1 Nef. Biochem.J., 478, 2021
3TB8	Crystal structure of full-length myristoylated HIV-1 Nef Descriptor: Protein Nef Authors: Dennis, C.A, Harris, M, Jaeger, J. Deposit date: 2011-08-05 Release date: 2012-10-03 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (3.71 Å) Cite: Crystal structure of full-length myristoylated HIV-1 Nef To be Published
3REB	HIV-1 Nef protein in complex with engineered Hck-SH3 domain Descriptor: Protein Nef, Tyrosine-protein kinase HCK Authors: Schulte, A, Blankenfeldt, W, Geyer, M. Deposit date: 2011-04-04 Release date: 2011-06-01 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (3.45 Å) Cite: Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef. PLoS ONE, 6, 2011
3REA	HIV-1 Nef protein in complex with engineered Hck-SH3 domain Descriptor: Protein Nef, Tyrosine-protein kinase HCK Authors: Schulte, A, Blankenfeldt, W, Geyer, M. Deposit date: 2011-04-04 Release date: 2011-06-01 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef. PLoS ONE, 6, 2011
3RBB	HIV-1 NEF protein in complex with engineered HCK SH3 domain Descriptor: 1,2-ETHANEDIOL, Protein Nef, Tyrosine-protein kinase HCK Authors: Horenkamp, F.A, Schulte, A, Weyand, M, Geyer, M. Deposit date: 2011-03-29 Release date: 2011-04-27 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Conformation of the Dileucine-Based Sorting Motif in HIV-1 Nef Revealed by Intermolecular Domain Assembly. Traffic, 12, 2011
3IOZ	SIVmac239 Nef in complex with a TCR zeta polypeptide DP1 (L51-D93) Descriptor: Protein Nef, T-cell surface glycoprotein CD3 zeta chain Authors: Kim, W.M, Sigalov, A.B, Stern, L.J. Deposit date: 2009-08-15 Release date: 2010-02-02 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (3.699 Å) Cite: Pseudo-merohedral twinning and noncrystallographic symmetry in orthorhombic crystals of SIVmac239 Nef core domain bound to different-length TCRzeta fragments. Acta Crystallogr.,Sect.D, 66, 2010
3IK5	SIVmac239 Nef in complex with TCR zeta ITAM 1 polypeptide (A63-R80) Descriptor: Protein Nef, T-cell surface glycoprotein CD3 zeta chain Authors: Kim, W.M, Sigalov, A.B, Stern, L.J. Deposit date: 2009-08-05 Release date: 2010-02-02 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Pseudo-merohedral twinning and noncrystallographic symmetry in orthorhombic crystals of SIVmac239 Nef core domain bound to different-length TCRzeta fragments. Acta Crystallogr.,Sect.D, 66, 2010
2XI1	Crystal structure of the HIV-1 Nef sequenced from a patient's sample Descriptor: NEF Authors: Yadav, G.P, Singh, P, Gupta, S, Tripathi, A.K, Tripathi, R.K, Ramachandran, R. Deposit date: 2010-06-25 Release date: 2011-08-10 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (3.5 Å) Cite: A Novel Dimer-Tetramer Transition Captured by the Crystal Structure of the HIV-1 Nef. Plos One, 6, 2011
2NEF	HIV-1 NEF (REGULATORY FACTOR), NMR, 40 STRUCTURES Descriptor: NEGATIVE FACTOR (F-PROTEIN) Authors: Grzesiek, S, Bax, A, Clore, G.M, Gronenborn, A.M, Hu, J.S, Kaufman, J, Palmer, I, Stahl, S.J, Tjandra, N, Wingfield, P.T. Deposit date: 1997-02-12 Release date: 1997-07-07 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Refined solution structure and backbone dynamics of HIV-1 Nef. Protein Sci., 6, 1997
1EFN	HIV-1 NEF PROTEIN IN COMPLEX WITH R96I MUTANT FYN SH3 DOMAIN Descriptor: FYN TYROSINE KINASE, HIV-1 NEF PROTEIN, TRIMETHYL LEAD ION Authors: Lee, C.-H, Kuriyan, J. Deposit date: 1996-06-29 Release date: 1997-01-11 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain. Cell(Cambridge,Mass.), 85, 1996
1AVZ	V-1 NEF PROTEIN IN COMPLEX WITH WILD TYPE FYN SH3 DOMAIN Descriptor: FYN TYROSINE KINASE, NEGATIVE FACTOR Authors: Arold, S, Franken, P, Dumas, C. Deposit date: 1997-09-23 Release date: 1998-03-25 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (3 Å) Cite: The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling. Structure, 5, 1997
1AVV	HIV-1 NEF PROTEIN, UNLIGANDED CORE DOMAIN Descriptor: NEGATIVE FACTOR Authors: Arold, S, Franken, P, Dumas, C. Deposit date: 1997-09-21 Release date: 1998-03-25 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (3 Å) Cite: The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling. Structure, 5, 1997

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