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8F2P
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Nef SF2 dimerization mutant bound to Hck SH3
分子名称: C-terminal core protein, Tyrosine-protein kinase HCK
著者Thomas, C.E, Alvarado, J.J, Smithgall, T.E.
登録日2022-11-08
公開日2023-02-22
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.63 Å)
主引用文献Neutron Reflectometry and Molecular Simulations Demonstrate HIV-1 Nef Homodimer Formation on Model Lipid Bilayers.
J.Mol.Biol., 435, 2023
8D9W
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BU of 8d9w by Molmil
beta-Arf1 homodimeric interface within AP-1, Arf1, Nef, MHC-I lattice on narrow tubes
分子名称: ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ...
著者Hooy, R.H, Hurley, J.H.
登録日2022-06-11
公開日2023-07-05
実験手法ELECTRON MICROSCOPY (9.3 Å)
主引用文献Self-assembly and structure of a clathrin-independent AP-1:Arf1 tubular membrane coat.
Sci Adv, 8, 2022
8D9V
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gamma-Arf1 homodimeric interface within AP-1, Arf1, Nef lattice on narrow membrane tubes
分子名称: ADP ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ...
著者Hooy, R.M, Hurley, J.H.
登録日2022-06-11
公開日2022-11-09
実験手法ELECTRON MICROSCOPY (9.4 Å)
主引用文献Self-assembly and structure of a clathrin-independent AP-1:Arf1 tubular membrane coat.
Sci Adv, 8, 2022
8D9U
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BU of 8d9u by Molmil
AP-1, Arf1, Nef lattice on MHC-I lipopeptide incorporated narrow membrane tubes, centered on beta-Arf1
分子名称: ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ...
著者Hooy, R.M, Hurley, J.H.
登録日2022-06-11
公開日2022-11-09
最終更新日2022-12-21
実験手法ELECTRON MICROSCOPY (20 Å)
主引用文献Self-assembly and structure of a clathrin-independent AP-1:Arf1 tubular membrane coat.
Sci Adv, 8, 2022
8D9T
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BU of 8d9t by Molmil
AP-1, Arf1, Nef lattice on MHC-I lipopeptide incorporated narrow membrane tubes, centered on gamma-Arf1
分子名称: ADP ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ...
著者Hooy, R.M, Hurley, J.H.
登録日2022-06-11
公開日2022-11-09
最終更新日2022-12-21
実験手法ELECTRON MICROSCOPY (20 Å)
主引用文献Self-assembly and structure of a clathrin-independent AP-1:Arf1 tubular membrane coat.
Sci Adv, 8, 2022
8D9S
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BU of 8d9s by Molmil
AP-1, Arf1, Nef lattice on MHC-I lipopeptide incorporated wide membrane tubes, centered on beta-Arf1
分子名称: ADP ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ...
著者Hooy, R.M, Hurley, J.H.
登録日2022-06-11
公開日2022-11-09
最終更新日2022-12-21
実験手法ELECTRON MICROSCOPY (20 Å)
主引用文献Self-assembly and structure of a clathrin-independent AP-1:Arf1 tubular membrane coat.
Sci Adv, 8, 2022
8D9R
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BU of 8d9r by Molmil
AP-1, Arf1, Nef lattice on MHC-I lipopeptide incorporated wide membrane tubes, centered on gamma-Arf1
分子名称: ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ...
著者Hooy, R.M, Hurley, J.H.
登録日2022-06-11
公開日2022-11-09
最終更新日2022-12-21
実験手法ELECTRON MICROSCOPY (20 Å)
主引用文献Self-assembly and structure of a clathrin-independent AP-1:Arf1 tubular membrane coat.
Sci Adv, 8, 2022
8D4G
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BU of 8d4g by Molmil
gamma-Arf1 mediated dimeric assembly of AP-1, Arf1, Nef complex within lattice on MHC-I lipopeptide incorporated wide(r) membrane tubes
分子名称: ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ...
著者Hooy, R.M, Hurley, J.H.
登録日2022-06-01
公開日2023-06-14
実験手法ELECTRON MICROSCOPY (11.6 Å)
主引用文献Self-assembly and structure of a clathrin-independent AP-1:Arf1 tubular membrane coat.
Sci Adv, 8, 2022
8D4F
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BU of 8d4f by Molmil
beta-Arf1 mediated dimeric assembly of AP-1, Arf1, Nef complex within lattice on MHC-I lipopeptide incorporated wide(r) membrane tubes
分子名称: ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ...
著者Hooy, R.M, Hurley, J.H.
登録日2022-06-01
公開日2023-06-14
実験手法ELECTRON MICROSCOPY (9.8 Å)
主引用文献Self-assembly and structure of a clathrin-independent AP-1:Arf1 tubular membrane coat.
Sci Adv, 8, 2022
8D4E
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BU of 8d4e by Molmil
Asymmetric unit of AP-1, Arf1, Nef lattice on MHC-I lipopeptide incorporated wide(r) membrane tubes
分子名称: ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ...
著者Hooy, R.M, Hurley, J.H.
登録日2022-06-01
公開日2023-06-14
実験手法ELECTRON MICROSCOPY (9.2 Å)
主引用文献Self-assembly and structure of a clathrin-independent AP-1:Arf1 tubular membrane coat.
Sci Adv, 8, 2022
8D4D
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BU of 8d4d by Molmil
gamma-Arf1 mediated dimeric assembly of AP-1, Arf1, Nef complex within lattice on MHC-I lipopeptide incorporated narrow membrane tubes
分子名称: ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ...
著者Hooy, R.M, Hurley, J.H.
登録日2022-06-01
公開日2023-06-14
実験手法ELECTRON MICROSCOPY (9.6 Å)
主引用文献Self-assembly and structure of a clathrin-independent AP-1:Arf1 tubular membrane coat.
Sci Adv, 8, 2022
8D4C
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BU of 8d4c by Molmil
beta-Arf1 mediated dimeric assembly of AP-1, Arf1, Nef complex within lattice on MHC-I lipopeptide incorporated narrow membrane tubes
分子名称: ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ...
著者Hooy, R.M, Hurley, J.H.
登録日2022-06-01
公開日2023-06-14
実験手法ELECTRON MICROSCOPY (9.3 Å)
主引用文献Self-assembly and structure of a clathrin-independent AP-1:Arf1 tubular membrane coat.
Sci Adv, 8, 2022
7UX3
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BU of 7ux3 by Molmil
Asymmetric unit of AP-1, Arf1, Nef lattice on MHC-I lipopeptide incorporated narrow membrane tubes
分子名称: ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ...
著者Hooy, R.M, Hurley, J.H.
登録日2022-05-04
公開日2023-05-10
最終更新日2023-06-14
実験手法ELECTRON MICROSCOPY (9.6 Å)
主引用文献Self-assembly and structure of a clathrin-independent AP-1:Arf1 tubular membrane coat.
Sci Adv, 8, 2022
7D7S
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BU of 7d7s by Molmil
HIV-1 SF2 Nef in complex with the Fyn SH3 R96I mutant
分子名称: Protein Nef, Tyrosine-protein kinase Fyn
著者Aldehaiman, A, Shahul Hamed, U.F, Arold, S.T.
登録日2020-10-05
公開日2020-11-18
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.32 Å)
主引用文献Synergy and allostery in ligand binding by HIV-1 Nef.
Biochem.J., 478, 2021
6URI
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BU of 6uri by Molmil
HIV-1 Nef in complex with the CD4 cytoplasmic domain and the AP2 clathrin adaptor complex
分子名称: AP-2 complex subunit alpha, AP-2 complex subunit beta, AP-2 complex subunit mu, ...
著者Jia, X, Kwon, Y.
登録日2019-10-23
公開日2020-07-29
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural basis of CD4 downregulation by HIV-1 Nef.
Nat.Struct.Mol.Biol., 27, 2020
6OWT
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BU of 6owt by Molmil
Structure of SIVsmm Nef and SMM tetherin bound to the clathrin adaptor AP-2 complex
分子名称: AP-2 complex subunit alpha, AP-2 complex subunit beta, AP-2 complex subunit sigma, ...
著者Buffalo, C.Z, Ren, X, Hurley, J.H.
登録日2019-05-10
公開日2019-09-25
最終更新日2019-12-18
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Structural Basis for Tetherin Antagonism as a Barrier to Zoonotic Lentiviral Transmission.
Cell Host Microbe, 26, 2019
6K6N
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BU of 6k6n by Molmil
Crystal structure of SIVmac239 Nef protein
分子名称: Protein Nef
著者Hirao, K, Andrews, S, Kuroki, K, Kusaka, H, Tadokoro, T, Kita, S, Ose, T, Rowland-Jones, S, Maenaka, K.
登録日2019-06-04
公開日2020-03-25
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.0002 Å)
主引用文献Structure of HIV-2 Nef Reveals Features Distinct from HIV-1 Involved in Immune Regulation.
Iscience, 23, 2020
6DFF
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BU of 6dff by Molmil
Structure of the cargo bound AP-1:Arf1:tetherin-Nef monomer
分子名称: ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ...
著者Morris, K.L, Buffalo, C.Z, Ren, X, Hurley, J.H.
登録日2018-05-14
公開日2018-08-08
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献HIV-1 Nefs Are Cargo-Sensitive AP-1 Trimerization Switches in Tetherin Downregulation.
Cell, 174, 2018
6D84
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BU of 6d84 by Molmil
Structure of the cargo bound AP-1:Arf1:tetherin-Nef (L164A, L165A) dileucine mutant dimer
分子名称: ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ...
著者Buffalo, C.Z, Morris, K.L, Hurley, J.H.
登録日2018-04-25
公開日2018-08-08
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (6.72 Å)
主引用文献HIV-1 Nefs Are Cargo-Sensitive AP-1 Trimerization Switches in Tetherin Downregulation.
Cell, 174, 2018
6D83
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BU of 6d83 by Molmil
Structure of the cargo bound AP-1:Arf1:tetherin-Nef (L164A, L165A) dileucine mutant dimer monomeric subunit
分子名称: ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ...
著者Buffalo, C.Z, Morris, K.L, Hurley, J.H.
登録日2018-04-25
公開日2018-08-08
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (4.27 Å)
主引用文献HIV-1 Nefs Are Cargo-Sensitive AP-1 Trimerization Switches in Tetherin Downregulation.
Cell, 174, 2018
6CRI
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BU of 6cri by Molmil
Structure of the cargo bound AP-1:Arf1:tetherin-Nef stable closed trimer
分子名称: ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ...
著者Morris, K.L, Buffalo, C.Z, Hurley, J.H.
登録日2018-03-18
公開日2018-08-01
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (6.8 Å)
主引用文献HIV-1 Nefs Are Cargo-Sensitive AP-1 Trimerization Switches in Tetherin Downregulation.
Cell, 174, 2018
6CM9
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BU of 6cm9 by Molmil
Structure of the cargo bound AP-1:Arf1:tetherin-Nef closed trimer monomeric subunit
分子名称: ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ...
著者Morris, K.L, Buffalo, C.Z, Ren, X, Hurley, J.H.
登録日2018-03-03
公開日2018-08-08
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (3.73 Å)
主引用文献HIV-1 Nefs Are Cargo-Sensitive AP-1 Trimerization Switches in Tetherin Downregulation.
Cell, 174, 2018
6B72
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BU of 6b72 by Molmil
A novel HIV-1 Nef dimer interface induced by a single octyl-glucoside molecule
分子名称: Protein Nef, octyl beta-D-glucopyranoside
著者Wu, M, Augelli-Szafran, C.E, Ptak, R.G, Smithgall, T.E.
登録日2017-10-03
公開日2018-02-21
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献A single beta-octyl glucoside molecule induces HIV-1 Nef dimer formation in the absence of partner protein binding.
PLoS ONE, 13, 2018
5NUI
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BU of 5nui by Molmil
Crystal structure of SIVmac239 Nef in an ExxxLM endocytic sorting motif bound state
分子名称: Protein Nef, SER-GLN-ILE-LYS-ARG-LEU-LEU-SER
著者Manrique, S, Horenkamp, F.A, Anand, K, Geyer, M.
登録日2017-04-30
公開日2017-08-16
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3.
Nat Commun, 8, 2017
5NUH
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Crystal structure of SIVmac239 Nef bound to an engineered Hck SH3 domain
分子名称: Protein Nef, Tyrosine-protein kinase HCK,Tyrosine-protein kinase HCK
著者Horenkamp, F.A, Anand, K, Geyer, M.
登録日2017-04-30
公開日2017-08-16
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.78 Å)
主引用文献Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3.
Nat Commun, 8, 2017

 

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