PDB: 413 件ウェブページステータス検索Chemie searchBIRD

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4G35	Mcl-1 in complex with a biphenyl cross-linked Noxa peptide. 分子名称: 4,4'-bis(bromomethyl)biphenyl, Induced myeloid leukemia cell differentiation protein Mcl-1 homolog, Noxa BH3 peptide (cysteine-mediated cross-linked) 著者 Drake, E, Edwardraja, S, Lin, Q, Gulick, A.M. 登録日 2012-07-13 公開日 2012-12-05 最終更新日 2013-06-26 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Rational design of proteolytically stable, cell-permeable peptide-based selective Mcl-1 inhibitors. J.Am.Chem.Soc., 134, 2012
4B4S	Crystal Structure of a pro-survival Bcl-2:Bim BH3 complex 分子名称: BCL-2-LIKE PROTEIN 10, BCL-2-LIKE PROTEIN 11, TETRAETHYLENE GLYCOL 著者 Rautureau, G.J.P, Hinds, M.G, Kvansakul, M. 登録日 2012-08-01 公開日 2013-01-16 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The Restricted Binding Repertoire of Bcl-B Leaves Bim as the Universal Bh3-Only Prosurvival Bcl-2 Protein Antagonist. Cell Death Dis., 3, 2012
4BD2	Bax domain swapped dimer in complex with BidBH3 分子名称: APOPTOSIS REGULATOR BAX, BH3-INTERACTING DOMAIN DEATH AGONIST 著者 Czabotar, P.E, Westphal, D, Adams, J.M, Colman, P.M. 登録日 2012-10-04 公開日 2013-02-13 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.206 Å) 主引用文献 Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis. Cell(Cambridge,Mass.), 152, 2013
4BD6	Bax domain swapped dimer in complex with BaxBH3 分子名称: APOPTOSIS REGULATOR BAX 著者 Czabotar, P.E, Westphal, D, Adams, J.M, Colman, P.M. 登録日 2012-10-05 公開日 2013-02-13 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.494 Å) 主引用文献 Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis. Cell(Cambridge,Mass.), 152, 2013
4BD8	Bax domain swapped dimer induced by BimBH3 with CHAPS 分子名称: 1,2-ETHANEDIOL, APOPTOSIS REGULATOR BAX, PRASEODYMIUM ION 著者 Czabotar, P.E, Westphal, D, Adams, J.M, Colman, P.M. 登録日 2012-10-05 公開日 2013-02-13 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.22 Å) 主引用文献 Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis. Cell(Cambridge,Mass.), 152, 2013
4BD7	Bax domain swapped dimer induced by octylmaltoside 分子名称: APOPTOSIS REGULATOR BAX, CHLORIDE ION, PRASEODYMIUM ION 著者 Czabotar, P.E, Westphal, D, Adams, J.M, Colman, P.M. 登録日 2012-10-05 公開日 2013-02-13 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.801 Å) 主引用文献 Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis. Cell(Cambridge,Mass.), 152, 2013
4BDU	Bax BH3-in-Groove dimer (GFP) 分子名称: GREEN FLUORESCENT PROTEIN, APOPTOSIS REGULATOR BAX 著者 Czabotar, P.E, Colman, P.M. 登録日 2012-10-08 公開日 2013-02-13 最終更新日 2019-10-23 実験手法 X-RAY DIFFRACTION (2.998 Å) 主引用文献 Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis. Cell(Cambridge,Mass.), 152, 2013
2M03	Solution structure of BCL-xL determined with selective isotope labelling of I,L,V sidechains 分子名称: Bcl-2-like protein 1 著者 Viacava Follis, A, Royappa, G, Kriwacki, R.W. 登録日 2012-10-19 公開日 2013-01-30 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis. Nat.Chem.Biol., 9, 2013
2M04	Solution structure of BCL-xL in complex with PUMA BH3 peptide 分子名称: Bcl-2-binding component 3, Bcl-2-like protein 1 著者 Viacava Follis, A, Royappa, G, Kriwacki, R.W. 登録日 2012-10-19 公開日 2013-01-30 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis. Nat.Chem.Biol., 9, 2013
4HNJ	Crystallographic structure of BCL-xL domain-swapped dimer in complex with PUMA BH3 peptide at 2.9A resolution 分子名称: Bcl-2-binding component 3, Bcl-2-like protein 1 著者 Fisher, J.C, Yun, M.K, White, S.W. 登録日 2012-10-19 公開日 2013-01-23 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis. Nat.Chem.Biol., 9, 2013
2YQ7	Structure of Bcl-xL bound to BimLOCK 分子名称: BCL-2-LIKE PROTEIN 1, BCL-2-LIKE PROTEIN 11, GLYCEROL 著者 Smith, B.J, Czabotar, P.E. 登録日 2012-11-06 公開日 2012-11-28 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.901 Å) 主引用文献 Stabilizing the Pro-Apoptotic Bimbh3 Helix (Bimsahb) Does not Necessarily Enhance Affinity or Biological Activity. Acs Chem.Biol., 8, 2013
2YQ6	Structure of Bcl-xL bound to BimSAHB 分子名称: BCL-2-LIKE PROTEIN 1, BIM BETA 5, GLYCEROL 著者 Smith, B.J, Czabotar, P.E. 登録日 2012-11-06 公開日 2012-11-28 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.799 Å) 主引用文献 Stabilizing the Pro-Apoptotic Bimbh3 Helix (Bimsahb) Does not Necessarily Enhance Affinity or Biological Activity. Acs Chem.Biol., 8, 2013
4HW2	Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design 分子名称: 1,2-ETHANEDIOL, 6-chloro-3-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-1H-indole-2-carboxylic acid, Induced myeloid leukemia cell differentiation protein Mcl-1, ... 著者 Zhao, B. 登録日 2012-11-07 公開日 2013-01-09 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design. J.Med.Chem., 56, 2013
4HW3	Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design 分子名称: 3-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-1-benzothiophene-2-carboxylic acid, Induced myeloid leukemia cell differentiation protein Mcl-1 著者 Zhao, B. 登録日 2012-11-07 公開日 2013-01-09 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design. J.Med.Chem., 56, 2013
4HW4	Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design 分子名称: Induced myeloid leukemia cell differentiation protein Mcl-1, Mcl-1 BH3 peptide 著者 Friberg, A, Zhao, B. 登録日 2012-11-07 公開日 2013-01-09 最終更新日 2013-03-06 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design. J.Med.Chem., 56, 2013
4IEH	Crystal Structure of human Bcl-2 in complex with a small molecule inhibitor targeting Bcl-2 BH3 domain interactions 分子名称: Apoptosis regulator Bcl-2, Bcl-2-like protein 1 chimera, N-(6-{4-[(4'-chlorobiphenyl-2-yl)methyl]piperazin-1-yl}-1,1-dioxido-1,2-benzothiazol-3-yl)-4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrobenzenesulfonamide 著者 Xie, X, Kulathila, R. 登録日 2012-12-13 公開日 2013-07-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The role of the acidity of N-heteroaryl sulfonamides as inhibitors of bcl-2 family protein-protein interactions. ACS Med Chem Lett, 4, 2013
3ZK6	Crystal structure of Bcl-xL in complex with inhibitor (Compound 2). 分子名称: BCL-2-LIKE PROTEIN 1, N-(3-(5-(1-(2-(benzo[d]thiazol-2-yl)hydrazono)ethyl)furan-2-yl)phenylsulfonyl)-6-phenylhexanamide 著者 Czabotar, P.E, Lessene, G.L, Smith, B.J, Colman, P.M. 登録日 2013-01-22 公開日 2013-04-24 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.48 Å) 主引用文献 Structure-Guided Design of a Selective Bcl-Xl Inhibitor Nat.Chem.Biol., 9, 2013
3ZLR	Crystal structure of BCL-XL in complex with inhibitor (WEHI-539) 分子名称: 1,2-ETHANEDIOL, 5-[3-[4-(aminomethyl)phenoxy]propyl]-2-[(8E)-8-(1,3-benzothiazol-2-ylhydrazinylidene)-6,7-dihydro-5H-naphthalen-2-yl]-1,3-thiazole-4-carboxylic acid, BCL-2-LIKE PROTEIN 1, ... 著者 Czabotar, P.E, Lessene, G.L, Smith, B.J, Colman, P.M. 登録日 2013-02-04 公開日 2013-04-24 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.026 Å) 主引用文献 Structure-Guided Design of a Selective Bcl-Xl Inhibitor Nat.Chem.Biol., 9, 2013
3ZLO	Crystal structure of BCL-XL in complex with inhibitor (Compound 6) 分子名称: 2-[(8E)-8-(1,3-benzothiazol-2-ylhydrazinylidene)-6,7-dihydro-5H-naphthalen-2-yl]-5-(4-phenylbutyl)-1,3-thiazole-4-carboxylic acid, BCL-2-LIKE PROTEIN 1 著者 Czabotar, P.E, Lessene, G.L, Smith, B.J, Colman, P.M. 登録日 2013-02-04 公開日 2013-04-24 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.601 Å) 主引用文献 Structure-Guided Design of a Selective Bcl-Xl Inhibitor Nat.Chem.Biol., 9, 2013
3ZLN	Crystal structure of BCL-XL in complex with inhibitor (Compound 3) 分子名称: 1,2-ETHANEDIOL, 6-[(8E)-8-(1,3-benzothiazol-2-ylhydrazinylidene)-6,7-dihydro-5H-naphthalen-2-yl]pyridine-2-carboxylic acid, BCL-2-LIKE PROTEIN 1, ... 著者 Czabotar, P.E, Lessene, G.L, Smith, B.J, Colman, P.M. 登録日 2013-02-04 公開日 2013-04-24 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.288 Å) 主引用文献 Structure-Guided Design of a Selective Bcl-Xl Inhibitor Nat.Chem.Biol., 9, 2013
2M5B	The NMR structure of the BID-BAK complex 分子名称: Bcl-2 homologous antagonist/killer, human_BID_BH3_SAHB 著者 Moldoveanu, T, Grace, C.R, Kriwacki, R.W, Green, D.R. 登録日 2013-02-19 公開日 2013-04-17 最終更新日 2023-11-15 実験手法 SOLUTION NMR 主引用文献 BID-induced structural changes in BAK promote apoptosis. Nat.Struct.Mol.Biol., 20, 2013
4K5A	Co-crystallization with conformation-specific designed ankyrin repeat proteins explains the conformational flexibility of BCL-W 分子名称: Bcl-2-like protein 2, Designed Ankyrin Repeat Protein 013_D12 著者 Schilling, J, Schoeppe, J, Sauer, E, Plueckthun, A. 登録日 2013-04-14 公開日 2014-04-16 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Co-Crystallization with Conformation-Specific Designed Ankyrin Repeat Proteins Explains the Conformational Flexibility of BCL-W J.Mol.Biol., 426, 2014
4K5B	Co-crystallization with conformation-specific designed ankyrin repeat proteins explains the conformational flexibility of BCL-W 分子名称: Apoptosis regulator BCL-W, Bcl-2-like protein 2 著者 Schilling, J, Schoeppe, J, Sauer, E, Plueckthun, A. 登録日 2013-04-14 公開日 2014-04-16 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Co-Crystallization with Conformation-Specific Designed Ankyrin Repeat Proteins Explains the Conformational Flexibility of BCL-W J.Mol.Biol., 426, 2014
4BPJ	Mcl-1 bound to alpha beta Puma BH3 peptide 3 分子名称: ALPHA BETA BH3-PEPTIDE, CHLORIDE ION, FUSION PROTEIN CONSISTING OF INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN MCL-1 HOMOLOG, ... 著者 Smith, B.J, Lee, E.F, Checco, J.W, Gellman, S.H, Fairlie, W.D. 登録日 2013-05-27 公開日 2014-04-09 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.599 Å) 主引用文献 Structure-Guided Rational Design of Alpha/Beta-Peptide Foldamers with High Affinity for Bcl-2 Family Prosurvival Proteins. Chembiochem, 14, 2013
4BPI	Mcl-1 bound to alpha beta Puma BH3 peptide 2 分子名称: ALPHA BETA BH3PEPTIDE, CADMIUM ION, FUSION PROTEIN CONSISTING OF INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN MCL-1 HOMOLOG 著者 Smith, B.J, Lee, E.F, Checco, J.W, Gellman, S.H, Fairlie, W.D. 登録日 2013-05-27 公開日 2014-04-09 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.982 Å) 主引用文献 Structure-Guided Rational Design of Alpha/Beta-Peptide Foldamers with High Affinity for Bcl-2 Family Prosurvival Proteins. Chembiochem, 14, 2013

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