4IEH
Crystal Structure of human Bcl-2 in complex with a small molecule inhibitor targeting Bcl-2 BH3 domain interactions
Summary for 4IEH
Entry DOI | 10.2210/pdb4ieh/pdb |
Descriptor | Apoptosis regulator Bcl-2, Bcl-2-like protein 1 chimera, N-(6-{4-[(4'-chlorobiphenyl-2-yl)methyl]piperazin-1-yl}-1,1-dioxido-1,2-benzothiazol-3-yl)-4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrobenzenesulfonamide (3 entities in total) |
Functional Keywords | protein-protein interaction, alpha helical, pro-apoptosis, cytochrome c release, caspase activation, bim, bak, bad, puma, apoptosis-inhibitor complex, apoptosis/inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Mitochondrion outer membrane ; Single-pass membrane protein : P10415 |
Total number of polymer chains | 1 |
Total formula weight | 20514.32 |
Authors | Xie, X.,Kulathila, R. (deposition date: 2012-12-13, release date: 2013-07-10, Last modification date: 2024-02-28) |
Primary citation | Toure, B.B.,Miller-Moslin, K.,Yusuff, N.,Perez, L.,Dore, M.,Joud, C.,Michael, W.,DiPietro, L.,van der Plas, S.,McEwan, M.,Lenoir, F.,Hoe, M.,Karki, R.,Springer, C.,Sullivan, J.,Levine, K.,Fiorilla, C.,Xie, X.,Kulathila, R.,Herlihy, K.,Porter, D.,Visser, M. The role of the acidity of N-heteroaryl sulfonamides as inhibitors of bcl-2 family protein-protein interactions. ACS Med Chem Lett, 4:186-190, 2013 Cited by PubMed: 24900652DOI: 10.1021/ml300321d PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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