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4IEH

Crystal Structure of human Bcl-2 in complex with a small molecule inhibitor targeting Bcl-2 BH3 domain interactions

Functional Information from GO Data
ChainGOidnamespacecontents
A0042981biological_processregulation of apoptotic process
Functional Information from PDB Data
site_idAC1
Number of Residues20
DetailsBINDING SITE FOR RESIDUE 1E9 A 201
ChainResidue
AALA59
AALA108
AGLU124
AMET125
ASER126
APHE157
ATYR161
AHOH319
AHOH360
AHOH366
AHOH367
AASP62
AHOH436
AARG66
ATYR67
APHE71
AMET74
AGLY104
AARG105
AVAL107

Functional Information from PROSITE/UniProt
site_idPS01080
Number of Residues19
DetailsBH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. LFrDGv.NWGRIVAFFeFGG
ChainResidueDetails
ALEU96-GLY114

site_idPS01258
Number of Residues12
DetailsBH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIqdnGGWDaFV
ChainResidueDetails
ATRP147-VAL158

site_idPS01259
Number of Residues15
DetailsBH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. VhltLRqAGDDFSRR
ChainResidueDetails
AVAL52-ARG66

site_idPS01260
Number of Residues21
DetailsBH4_1 Apoptosis regulator, Bcl-2 family BH4 motif signature. DNREIVmKYIHYKLSQRGYeW
ChainResidueDetails
AASP10-TRP30

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Cleavage; by caspase-3
ChainResidueDetails
AASP34

222415

PDB entries from 2024-07-10

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