4IEH
Crystal Structure of human Bcl-2 in complex with a small molecule inhibitor targeting Bcl-2 BH3 domain interactions
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Apoptosis regulator Bcl-2, Bcl-2-like protein 1 chimera | polymer | 169 | 19639.8 | 1 | UniProt (P10415) UniProt (Q07817) Pfam (PF02180) Pfam (PF00452) In PDB | Homo sapiens (human) | Bcl2-L-1, Apoptosis regulator Bcl-X |
| 2 | A | N-(6-{4-[(4'-chlorobiphenyl-2-yl)methyl]piperazin-1-yl}-1,1-dioxido-1,2-benzothiazol-3-yl)-4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrobenzenesulfonamide | non-polymer | 874.5 | 1 | Chemie (1E9) | |||
| 3 | water | water | 18.0 | 184 | Chemie (HOH) |
Sequence modifications
A: 1 - 34 (UniProt: P10415)
A: 35 - 50 (UniProt: Q07817)
A: 51 - 166 (UniProt: P10415)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | cloning artifact |
| Ser -1 | - | cloning artifact |
| His 0 | - | cloning artifact |
A: 51 - 166 (UniProt: P10415)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 19639.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 874.5 | |
| All* | Total formula weight | 20514.3 |
