5EMJ
| Crystal structure of PRMT5:MEP50 with Compound 8 and sinefungin | Descriptor: | (2~{S})-1-(3,4-dihydro-1~{H}-isoquinolin-2-yl)-3-[[4-(3-methylbenzimidazol-5-yl)pyridin-2-yl]amino]propan-2-ol, GLYCEROL, Methylosome protein 50, ... | Authors: | Boriack-Sjodin, P.A, Jin, L. | Deposit date: | 2015-11-06 | Release date: | 2016-02-24 | Last modified: | 2018-04-18 | Method: | X-RAY DIFFRACTION (2.273 Å) | Cite: | Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666. ACS Med Chem Lett, 7, 2016
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5FXY
| Structure of the human RBBP4:MTA1(464-546) complex | Descriptor: | HISTONE-BINDING PROTEIN RBBP4, METASTASIS-ASSOCIATED PROTEIN MTA1 | Authors: | Millard, C.J, Varma, N, Fairall, L, Schwabe, J.W.R. | Deposit date: | 2016-03-03 | Release date: | 2016-05-18 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | The structure of the core NuRD repression complex provides insights into its interaction with chromatin. Elife, 5, 2016
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5FA5
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5FLC
| Architecture of human mTOR Complex 1 - 5.9 Angstrom reconstruction | Descriptor: | FKBP, RAPAMYCIN IMMUNOSUPPRESSANT DRUG, REGULATORY-ASSOCIATED PROTEIN OF MTOR, ... | Authors: | Aylett, C.H.S, Sauer, E, Imseng, S, Boehringer, D, Hall, M.N, Ban, N, Maier, T. | Deposit date: | 2015-10-23 | Release date: | 2015-12-30 | Last modified: | 2019-04-24 | Method: | ELECTRON MICROSCOPY (5.9 Å) | Cite: | Architecture of Human Mtor Complex 1 Science, 351, 2016
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5G04
| Structure of the human APC-Cdc20-Hsl1 complex | Descriptor: | ANAPHASE-PROMOTING COMPLEX SUBUNIT 1, ANAPHASE-PROMOTING COMPLEX SUBUNIT 10, ANAPHASE-PROMOTING COMPLEX SUBUNIT 11, ... | Authors: | Zhang, S, Chang, L, Alfieri, C, Zhang, Z, Yang, J, Maslen, S, Skehel, M, Barford, D. | Deposit date: | 2016-03-16 | Release date: | 2016-05-25 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Molecular Mechanism of Apc/C Activation by Mitotic Phosphorylation. Nature, 533, 2016
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4WJU
| Crystal structure of Rsa4 from Saccharomyces cerevisiae | Descriptor: | GLYCEROL, Ribosome assembly protein 4 | Authors: | Holdermann, I, Bassler, J, Hurt, E, Sinning, I. | Deposit date: | 2014-10-01 | Release date: | 2014-11-19 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation. J.Cell Biol., 207, 2014
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4X63
| Crystal structure of PRMT5:MEP50 with EPZ015666 and SAH | Descriptor: | Methylosome protein 50, N-[(2S)-3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl]-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide, Protein arginine N-methyltransferase 5, ... | Authors: | Boriack-Sjodin, P.A. | Deposit date: | 2014-12-06 | Release date: | 2015-04-22 | Last modified: | 2015-05-27 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models. Nat.Chem.Biol., 11, 2015
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4X60
| Crystal structure of PRMT5:MEP50 with EPZ015666 and sinefungin | Descriptor: | GLYCEROL, Methylosome protein 50, N-[(2S)-3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl]-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide, ... | Authors: | Boriack-Sjodin, P.A. | Deposit date: | 2014-12-06 | Release date: | 2015-04-22 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models. Nat.Chem.Biol., 11, 2015
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4X61
| Crystal structure of PRMT5:MEP50 with EPZ015666 and SAM | Descriptor: | GLYCEROL, Methylosome protein 50, N-[(2S)-3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl]-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide, ... | Authors: | Boriack-Sjodin, P.A. | Deposit date: | 2014-12-06 | Release date: | 2015-04-22 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models. Nat.Chem.Biol., 11, 2015
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4A08
| Structure of hsDDB1-drDDB2 bound to a 13 bp CPD-duplex (purine at D-1 position) at 3.0 A resolution (CPD 1) | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5'-D(*AP*CP*GP*CP*GP*AP*(TTD)P*GP*CP*GP*CP*CP*C)-3', 5'-D(*TP*GP*GP*GP*CP*GP*CP*CP*CP*TP*CP*GP*CP*G)-3', ... | Authors: | Scrima, A, Fischer, E.S, Iwai, S, Gut, H, Thoma, N.H. | Deposit date: | 2011-09-08 | Release date: | 2011-11-30 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The Molecular Basis of Crl4(Ddb2/Csa) Ubiquitin Ligase Architecture, Targeting, and Activation Cell(Cambridge,Mass.), 147, 2011
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4XMN
| Structure of the yeast coat nucleoporin complex, space group P212121 | Descriptor: | Antibody 87 heavy chain, Antibody 87 light chain, Nucleoporin NUP120, ... | Authors: | Stuwe, T, Correia, A.R, Lin, D.H, Paduch, M, Lu, V.T, Kossiakoff, A.A, Hoelz, A. | Deposit date: | 2015-01-14 | Release date: | 2015-03-25 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (7.6 Å) | Cite: | Nuclear pores. Architecture of the nuclear pore complex coat. Science, 347, 2015
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4A11
| Structure of the hsDDB1-hsCSA complex | Descriptor: | DNA DAMAGE-BINDING PROTEIN 1, DNA EXCISION REPAIR PROTEIN ERCC-8 | Authors: | Bohm, K, Scrima, A, Fischer, E.S, Gut, H, Thomae, N.H. | Deposit date: | 2011-09-13 | Release date: | 2011-12-07 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.31 Å) | Cite: | The Molecular Basis of Crl4(Ddb2/Csa) Ubiquitin Ligase Architecture, Targeting, and Activation. Cell(Cambridge,Mass.), 147, 2011
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4XMM
| Structure of the yeast coat nucleoporin complex, space group C2 | Descriptor: | Antibody 57 heavy chain, Antibody 57 light chain, Nucleoporin NUP120, ... | Authors: | Stuwe, T, Correia, A.R, Lin, D.H, Paduch, M, Lu, V.T, Kossiakoff, A.A, Hoelz, A. | Deposit date: | 2015-01-14 | Release date: | 2015-03-25 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (7.384 Å) | Cite: | Nuclear pores. Architecture of the nuclear pore complex coat. Science, 347, 2015
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4A0K
| STRUCTURE OF DDB1-DDB2-CUL4A-RBX1 BOUND TO A 12 BP ABASIC SITE CONTAINING DNA-DUPLEX | Descriptor: | 12 BP DNA, 12 BP THF CONTAINING DNA, CULLIN-4A, ... | Authors: | Fischer, E.S, Scrima, A, Gut, H, Thoma, N.H. | Deposit date: | 2011-09-09 | Release date: | 2011-12-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (5.93 Å) | Cite: | The Molecular Basis of Crl4(Ddb2/Csa) Ubiquitin Ligase Architecture, Targeting, and Activation. Cell(Cambridge,Mass.), 147, 2011
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4A0L
| Structure of DDB1-DDB2-CUL4B-RBX1 bound to a 12 bp abasic site containing DNA-duplex | Descriptor: | 12 BP DNA DUPLEX, 12 BP THF CONTAINING DNA DUPLEX, CULLIN-4B, ... | Authors: | Fischer, E.S, Scrima, A, Gut, H, Thoma, N.H. | Deposit date: | 2011-09-09 | Release date: | 2011-12-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (7.4 Å) | Cite: | The Molecular Basis of Crl4(Ddb2/Csa) Ubiquitin Ligase Architecture, Targeting, and Activation. Cell(Cambridge,Mass.), 147, 2011
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4A0B
| Structure of hsDDB1-drDDB2 bound to a 16 bp CPD-duplex (pyrimidine at D-1 position) at 3.8 A resolution (CPD 4) | Descriptor: | 5'-D(*CP*CP*TP*GP*CP*TP*CP*CP*TP*TP*TP*CP*AP*CP*CP*C)-3', 5'-D(*DGP*GP*TP*GP*AP*AP*AP*(TTD)P*AP*GP*CP*AP*GP*DGP)-3', DNA DAMAGE-BINDING PROTEIN 1, ... | Authors: | Scrima, A, Fischer, E.S, Iwai, S, Gut, H, Thoma, N.H. | Deposit date: | 2011-09-08 | Release date: | 2011-11-30 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | The Molecular Basis of Crl4(Ddb2/Csa) Ubiquitin Ligase Architecture, Targeting, and Activation Cell(Cambridge,Mass.), 147, 2011
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4A0A
| Structure of hsDDB1-drDDB2 bound to a 16 bp CPD-duplex (pyrimidine at D-1 position) at 3.6 A resolution (CPD 3) | Descriptor: | 5'-D(*CP*CP*TP*GP*CP*TP*CP*CP*TP*TP*TP*CP*AP*CP*CP*C)-3', 5'-D(*GP*GP*TP*GP*AP*AP*AP*(TTD)P*AP*GP*CP*AP*GP*DGP)-3', CALCIUM ION, ... | Authors: | Scrima, A, Fischer, E.S, Iwai, S, Gut, H, Thoma, N.H. | Deposit date: | 2011-09-08 | Release date: | 2011-11-30 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | The Molecular Basis of Crl4(Ddb2/Csa) Ubiquitin Ligase Architecture, Targeting, and Activation Cell(Cambridge,Mass.), 147, 2011
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4A09
| Structure of hsDDB1-drDDB2 bound to a 15 bp CPD-duplex (purine at D-1 position) at 3.1 A resolution (CPD 2) | Descriptor: | 5'-D(*CP*CP*TP*GP*CP*TP*CP*CP*TP*TP*TP*CP*AP*CP*CP*C)-3', 5'-D(*GP*GP*TP*GP*AP*AP*AP*(TTD)P*AP*GP*CP*AP*GP*GP)-3', CALCIUM ION, ... | Authors: | Scrima, A, Fischer, E.S, Iwai, S, Gut, H, Thoma, N.H. | Deposit date: | 2011-09-08 | Release date: | 2011-11-30 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | The Molecular Basis of Crl4(Ddb2/Csa) Ubiquitin Ligase Architecture, Targeting, and Activation Cell(Cambridge,Mass.), 147, 2011
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4XYH
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4AEZ
| Crystal Structure of Mitotic Checkpoint Complex | Descriptor: | MITOTIC SPINDLE CHECKPOINT COMPONENT MAD2, MITOTIC SPINDLE CHECKPOINT COMPONENT MAD3, WD REPEAT-CONTAINING PROTEIN SLP1 | Authors: | Kulkarni, K.A, Chao, W.C.H, Zhang, Z, Barford, D. | Deposit date: | 2012-01-13 | Release date: | 2012-03-21 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of the Mitotic Checkpoint Complex Nature, 484, 2012
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4XYI
| Mis16 with H4 peptide | Descriptor: | Histone H4, Kinetochore protein Mis16 | Authors: | An, S, Kim, H, Cho, U.-S. | Deposit date: | 2015-02-02 | Release date: | 2016-02-03 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Mis16 Independently Recognizes Histone H4 and the CENP-ACnp1-Specific Chaperone Scm3sp. J.Mol.Biol., 427, 2015
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4YCZ
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4BL0
| Crystal structure of yeast Bub3-Bub1 bound to phospho-Spc105 | Descriptor: | CELL CYCLE ARREST PROTEIN BUB3, CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1, MAGNESIUM ION, ... | Authors: | Primorac, I, Weir, J.R, Musacchio, A. | Deposit date: | 2013-04-30 | Release date: | 2013-09-18 | Last modified: | 2013-10-09 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Bub3 Reads Phosphorylated Melt Repeats to Promote Spindle Assembly Checkpoint Signaling Elife, 2, 2013
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4BZK
| The structure of the COPII coat assembled on membranes | Descriptor: | Protein transport protein SEC13, Protein transport protein SEC31 | Authors: | Zanetti, G, Prinz, S, Daum, S, Meister, A, Schekman, R, Bacia, K, Briggs, J.A.G. | Deposit date: | 2013-07-26 | Release date: | 2013-09-18 | Last modified: | 2019-09-11 | Method: | ELECTRON MICROSCOPY (40 Å) | Cite: | The Structure of the Copii Transport-Vesicle Coat Assembled on Membranes Elife, 2, 2013
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4BZJ
| The structure of the COPII coat assembled on membranes | Descriptor: | Protein transport protein SEC13, Protein transport protein SEC31 | Authors: | Zanetti, G, Prinz, S, Daum, S, Meister, A, Schekman, R, Bacia, K, Briggs, J.A.G. | Deposit date: | 2013-07-26 | Release date: | 2013-09-18 | Last modified: | 2019-09-11 | Method: | ELECTRON MICROSCOPY (40 Å) | Cite: | The Structure of the Copii Transport-Vesicle Coat Assembled on Membranes Elife, 2, 2013
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