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1S55
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Mouse RANKL Structure at 1.9A Resolution
分子名称: CHLORIDE ION, Tumor necrosis factor ligand superfamily member 11
著者Teale, M.J, Feug, X, Chen, L, Bice, T, Meehan, E.J.
登録日2004-01-19
公開日2005-07-05
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Murine RANKL Extra Cellular Domain Homotrimer Structure In Space Groups P212121 And H3 At 1.9 And 2.6 Respectively
To be Published
1U5Y
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Crystal structure of murine APRIL, pH 8.0
分子名称: Tumor necrosis factor ligand superfamily member 13
著者Wallweber, H.J, Compaan, D.M, Starovasnik, M.A, Hymowitz, S.G.
登録日2004-07-28
公開日2004-10-12
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The Crystal Structure of A Proliferation-inducing Ligand, APRIL.
J.Mol.Biol., 343, 2004
1U5Z
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The Crystal structure of murine APRIL, pH 8.5
分子名称: NICKEL (II) ION, Tumor necrosis factor ligand superfamily member 13
著者Wallweber, H.J, Compaan, D.M, Starovasnik, M.A, Hymowitz, S.G.
登録日2004-07-28
公開日2004-10-12
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The Crystal Structure of A Proliferation-inducing Ligand, APRIL.
J.Mol.Biol., 343, 2004
1U5X
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Crystal structure of murine APRIL at pH 5.0
分子名称: Tumor necrosis factor ligand superfamily member 13
著者Wallweber, H.J, Compaan, D.M, Starovasnik, M.A, Hymowitz, S.G.
登録日2004-07-28
公開日2004-10-12
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The Crystal Structure of A Proliferation-inducing Ligand, APRIL.
J.Mol.Biol., 343, 2004
1XU1
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The crystal structure of APRIL bound to TACI
分子名称: NICKEL (II) ION, Tumor necrosis factor ligand superfamily member 13, Tumor necrosis factor receptor superfamily member 13B
著者Hymowitz, S.G, Patel, D.R, Wallweber, H.J.A, Runyon, S, Yan, M, Yin, J, Shriver, S.K, Gordon, N.C, Pan, B, Skelton, N.J, Kelley, R.F, Starovasnik, M.A.
登録日2004-10-25
公開日2004-11-09
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structures of APRIL-receptor complexes: Like BCMA, TACI employs only a single cysteine-rich domain for high-affinity ligand binding
J.Biol.Chem., 280, 2005
1XU2
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The crystal structure of APRIL bound to BCMA
分子名称: NICKEL (II) ION, Tumor necrosis factor ligand superfamily member 13, Tumor necrosis factor receptor superfamily member 17
著者Hymowitz, S.G, Patel, D.R, Wallweber, H.J.A, Runyon, S, Yan, M, Yin, J, Shriver, S.K, Gordon, N.C, Pan, B, Skelton, N.J, Kelley, R.F, Starovasnik, M.A.
登録日2004-10-25
公開日2004-11-09
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structures of APRIL-receptor complexes: Like BCMA, TACI employs only a single cysteine-rich domain for high-affinity ligand binding
J.Biol.Chem., 280, 2005
2AZ5
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Crystal Structure of TNF-alpha with a small molecule inhibitor
分子名称: 6,7-DIMETHYL-3-[(METHYL{2-[METHYL({1-[3-(TRIFLUOROMETHYL)PHENYL]-1H-INDOL-3-YL}METHYL)AMINO]ETHYL}AMINO)METHYL]-4H-CHROMEN-4-ONE, Tumor necrosis factor (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) (Cachectin) [Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, ...
著者He, M.M.
登録日2005-09-09
公開日2005-11-29
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Small-molecule inhibition of TNF-alpha.
Science, 310, 2005
2O0O
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Crystal structure of TL1A
分子名称: MAGNESIUM ION, TNF superfamily ligand TL1A
著者Jin, T.C, Kim, S, Guo, F, Howard, A.J, Zhang, Y.Z.
登録日2006-11-27
公開日2007-10-30
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献X-ray crystal structure of TNF ligand family member TL1A at 2.1A.
Biochem.Biophys.Res.Commun., 364, 2007
2E7A
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TNF Receptor Subtype One-selective TNF Mutant with Antagonistic Activity
分子名称: Tumor necrosis factor
著者Mukai, Y, Yamagata, Y, Tsutsumi, Y.
登録日2007-01-09
公開日2007-11-13
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Creation and X-ray structure analysis of the tumor necrosis factor receptor-1-selective mutant of a tumor necrosis factor-alpha antagonist
J.Biol.Chem., 283, 2008
2Q8O
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crystal structure of mouse GITR ligand dimer
分子名称: GITR ligand
著者Zhaocai, Z, Yukiko, T.
登録日2007-06-11
公開日2007-12-25
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structural basis for ligand-mediated mouse GITR activation.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2QDN
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Crystal Structure of mouse GITRL
分子名称: GITR ligand
著者Chattopadhyay, K, Ramagopal, U.A, Nathenson, S.G, Almo, S.C.
登録日2007-06-21
公開日2008-01-01
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Evolution of GITRL immune function: murine GITRL exhibits unique structural and biochemical properties within the TNF superfamily.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2QE3
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Crystal structure of human tl1a extracellular domain
分子名称: CHLORIDE ION, TNF superfamily ligand TL1A
著者Zhan, C, Yan, Q, Patskovsky, Y, Shi, W, Toro, R, Bonanno, J, Nathenson, S.G, Almo, S.C.
登録日2007-06-22
公開日2007-07-17
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Biochemical and structural characterization of the human TL1A ectodomain.
Biochemistry, 48, 2009
2RE9
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Crystal structure of TL1A at 2.1 A
分子名称: GLYCEROL, MAGNESIUM ION, TNF superfamily ligand TL1A
著者Jin, T.C, Guo, F, Kim, S, Howard, A.J, Zhang, Y.Z.
登録日2007-09-25
公開日2007-10-09
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献X-ray crystal structure of TNF ligand family member TL1A at 2.1 A.
Biochem.Biophys.Res.Commun., 364, 2007
2RJK
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Crystal Structure of Human TL1A Extracellular Domain C95S Mutant
分子名称: TNF superfamily ligand TL1A
著者Zhan, C, Yan, Q, Patskovsky, Y, Shi, W, Ramagopal, U.A, Toro, R, Bonanno, J, Nathenson, S.G, Almo, S.C.
登録日2007-10-15
公開日2008-08-26
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Biochemical and structural characterization of the human TL1A ectodomain.
Biochemistry, 48, 2009
2RJL
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Crystal structure of human TL1A extracellular domain C95S/C135S mutant
分子名称: TNF superfamily ligand TL1A
著者Zhan, C, Patskovsky, Y, Yan, Q, Shi, W, Toro, R, Bonanno, J, Nathenson, S.G, Almo, S.C.
登録日2007-10-15
公開日2008-08-26
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Biochemical and structural characterization of the human TL1A ectodomain.
Biochemistry, 48, 2009
3B9I
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Crystal Structure of mouse GITRL at 2.5 A.
分子名称: GITR ligand
著者Chattopadhyay, K, Ramagopal, U.A, Nathenson, S.G, Almo, S.C.
登録日2007-11-05
公開日2008-01-01
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献Evolution of GITRL immune function: murine GITRL exhibits unique structural and biochemical properties within the TNF superfamily.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2ZJC
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TNFR1 selectve TNF mutant; R1-6
分子名称: GLYCEROL, Tumor necrosis factor
著者Mukai, Y, Yamagata, Y, Tsutsumi, Y.
登録日2008-03-05
公開日2009-01-20
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure-Function Relationship of Tumor Necrosis Factor (TNF) and Its Receptor Interaction Based on 3D Structural Analysis of a Fully Active TNFR1-Selective TNF Mutant
J.Mol.Biol., 385, 2009
2ZPX
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TNF Receptor Subtype One-selective TNF Mutant with Antagonistic Activity; R1antTNF-T8
分子名称: Tumor necrosis factor
著者Mukai, Y, Nakamura, T, Yamagata, Y, Tsutsumi, Y.
登録日2008-07-29
公開日2009-03-24
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.83 Å)
主引用文献Fast binding kinetics and conserved 3D structure underlie the antagonistic activity of mutant TNF: useful information for designing artificial proteo-antagonists
J.Biochem., 146, 2009
3FC0
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1.8 A crystal structure of murine GITR ligand dimer expressed in Drosophila melanogaster S2 cells
分子名称: ACETATE ION, GITR ligand
著者Chattopadhyay, K, Ramagopal, U.A, Nathenson, S.G, Almo, S.C.
登録日2008-11-20
公開日2008-12-30
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献1.8 A structure of murine GITR ligand dimer expressed in Drosophila melanogaster S2 cells.
Acta Crystallogr.,Sect.D, 65, 2009
3IT8
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Crystal structure of TNF alpha complexed with a poxvirus MHC-related TNF binding protein
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2L protein, Tumor necrosis factor
著者Yang, Z, West Jr, A.P, Bjorkman, P.J.
登録日2009-08-27
公開日2009-10-20
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure of TNFalpha complexed with a poxvirus MHC-related TNF binding protein
Nat.Struct.Mol.Biol., 16, 2009
3K48
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Crystal structure of APRIL bound to a peptide
分子名称: Tumor necrosis factor ligand superfamily member 13, peptide
著者Hymowitz, S.G.
登録日2009-10-05
公開日2009-11-24
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Multiple novel classes of APRIL-specific receptor-blocking peptides isolated by phage display.
J.Mol.Biol., 396, 2010
3K51
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Crystal Structure of DcR3-TL1A complex
分子名称: Decoy receptor 3, Tumor necrosis factor ligand superfamily member 15, secreted form
著者Zhan, C, Patskovsky, Y, Yan, Q, Li, Z, Ramagopal, U.A, Nathenson, S.G, Almo, S.C.
登録日2009-10-06
公開日2010-10-13
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Decoy Strategies: The Structure of TL1A:DcR3 Complex.
Structure, 19, 2011
3L9J
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Selection of a novel highly specific TNFalpha antagonist: Insight from the crystal structure of the antagonist-TNFalpha complex
分子名称: MAGNESIUM ION, TNFalpha, Tumor necrosis factor, ...
著者Byla, P, Andersen, M.H, Thogersen, H.C, Gad, H.H, Hartmann, R.
登録日2010-01-05
公開日2010-02-23
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Selection of a novel and highly specific TNF{alpha} antagonist: insight from the crystal structure of the antagonist-TNF{alpha} complex
J.Biol.Chem., 285, 2010
2X29
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Crystal structure of human4-1BB ligand ectodomain
分子名称: TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 9
著者Won, E.Y, Cho, H.S.
登録日2010-01-12
公開日2010-03-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The Structure of the Trimer of Human 4-1Bb Ligand is Unique Among Members of the Tumor Necrosis Factor Superfamily.
J.Biol.Chem., 285, 2010
3LKJ
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Small Molecule Inhibition of the TNF Family Cyokine CD40 Ligand Through a Subunit Fracture Mechanism
分子名称: (2R)-{[(2'-[(biphenyl-3-ylmethyl)carbamoyl]-6'-{[(2R)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]carbonyl}-6-{[(2R)-2-(1H-pyrrol-1-ylmethyl)pyrrolidin-1-yl]carbonyl}-4,4'-bipyridin-2-yl)carbonyl]amino}(cyclohexyl)ethanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, CD40 ligand
著者Silvian, L.F, Whitty, A.
登録日2010-01-27
公開日2011-02-02
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Small Molecule Inhibition of the TNF Family Cytokine CD40 Ligand through a Subunit Fracture Mechanism.
Acs Chem.Biol., 6, 2011

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