PDB: 614 resultsInfo pagesStatus searchChemie searchBIRD

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1RX3	DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH METHOTREXATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (REDUCED FORM) Descriptor: BETA-MERCAPTOETHANOL, DIHYDROFOLATE REDUCTASE, MANGANESE (II) ION, ... Authors: Sawaya, M.R. Deposit date: 1996-09-19 Release date: 1997-01-11 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. Biochemistry, 36, 1997
1S3U	Structure Determination of Tetrahydroquinazoline Antifolates in Complex with Human and Pneumocystis carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry Descriptor: (2R,6S)-6-{[methyl(3,4,5-trimethoxyphenyl)amino]methyl}-1,2,5,6,7,8-hexahydroquinazoline-2,4-diamine, Dihydrofolate reductase, SULFATE ION Authors: Cody, V, Luft, J.R, Pangborn, W, Gangjee, A, Queener, S.F. Deposit date: 2004-01-14 Release date: 2004-03-30 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structure determination of tetrahydroquinazoline antifolates in complex with human and Pneumocystis carinii dihydrofolate reductase: correlations between enzyme selectivity and stereochemistry. Acta Crystallogr.,Sect.D, 60, 2004
1RB3	DIHYDROFOLATE REDUCTASE COMPLEXED WITH METHOTREXATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM) Descriptor: DIHYDROFOLATE REDUCTASE, METHOTREXATE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Sawaya, M.R, Kraut, J. Deposit date: 1996-11-26 Release date: 1997-03-12 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. Biochemistry, 36, 1997
1RA1	DIHYDROFOLATE REDUCTASE COMPLEXED WITH NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (REDUCED FORM) Descriptor: CALCIUM ION, DIHYDROFOLATE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Sawaya, M.R, Kraut, J. Deposit date: 1996-10-30 Release date: 1996-12-23 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. Biochemistry, 36, 1997
1RA3	DIHYDROFOLATE REDUCTASE COMPLEXED WITH METHOTREXATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM) Descriptor: BETA-MERCAPTOETHANOL, DIHYDROFOLATE REDUCTASE, METHOTREXATE, ... Authors: Sawaya, M.R, Kraut, J. Deposit date: 1996-10-28 Release date: 1996-12-23 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. Biochemistry, 36, 1997
1RB2	DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM) Descriptor: DIHYDROFOLATE REDUCTASE, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Sawaya, M.R, Kraut, J. Deposit date: 1996-11-26 Release date: 1997-03-12 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. Biochemistry, 36, 1997
1RE7	DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE Descriptor: DIHYDROFOLATE REDUCTASE, FOLIC ACID Authors: Sawaya, M.R. Deposit date: 1996-11-01 Release date: 1996-12-23 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. Biochemistry, 36, 1997
1RA2	DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM) Descriptor: DIHYDROFOLATE REDUCTASE, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Sawaya, M.R, Kraut, J. Deposit date: 1996-10-28 Release date: 1996-12-23 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. Biochemistry, 36, 1997
1RA8	DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND 2-MONOPHOSPHOADENOSINE 5'-DIPHOSPHORIBOSE Descriptor: 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE, DIHYDROFOLATE REDUCTASE, FOLIC ACID Authors: Sawaya, M.R, Kraut, J. Deposit date: 1996-11-21 Release date: 1997-03-12 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. Biochemistry, 36, 1997
1RD7	DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE Descriptor: BETA-MERCAPTOETHANOL, DIHYDROFOLATE REDUCTASE, FOLIC ACID Authors: Sawaya, M.R, Kraut, J. Deposit date: 1996-11-01 Release date: 1996-12-23 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. Biochemistry, 36, 1997
1RA9	DIHYDROFOLATE REDUCTASE COMPLEXED WITH NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM) Descriptor: DIHYDROFOLATE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Sawaya, M.R, Kraut, J. Deposit date: 1996-10-28 Release date: 1996-12-23 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. Biochemistry, 36, 1997
1RF7	STRUCTURE OF DIHYDROFOLATE REDUCTASE COMPLEXED WITH DIHYDROFOLATE Descriptor: CHLORIDE ION, DIHYDROFOLATE REDUCTASE, DIHYDROFOLIC ACID, ... Authors: Sawaya, M.R. Deposit date: 1996-10-24 Release date: 1997-03-12 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. Biochemistry, 36, 1997
1RG7	DIHYDROFOLATE REDUCTASE COMPLEXED WITH METHOTREXATE Descriptor: DIHYDROFOLATE REDUCTASE, METHOTREXATE Authors: Sawaya, M.R, Kraut, J. Deposit date: 1996-11-27 Release date: 1997-03-12 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2 Å) Cite: Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. Biochemistry, 36, 1997
1RH3	DIHYDROFOLATE REDUCTASE COMPLEXED WITH METHOTREXATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (REDUCED FORM) Descriptor: DIHYDROFOLATE REDUCTASE, METHOTREXATE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Sawaya, M.R, Kraut, J. Deposit date: 1996-11-27 Release date: 1997-03-12 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. Biochemistry, 36, 1997
1RX8	DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND 2'-MONOPHOSPHOADENOSINE 5'-DIPHOSPHORIBOSE Descriptor: BETA-MERCAPTOETHANOL, DIHYDROFOLATE REDUCTASE, FOLIC ACID, ... Authors: Sawaya, M.R. Deposit date: 1996-10-25 Release date: 1997-03-12 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. Biochemistry, 36, 1997
1S3V	Structure Determination of Tetrahydroquinazoline Antifolates in Complex with Human and Pneumocystis carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry Descriptor: (2R,6S)-6-{[methyl(3,4,5-trimethoxyphenyl)amino]methyl}-1,2,5,6,7,8-hexahydroquinazoline-2,4-diamine, Dihydrofolate reductase, SULFATE ION Authors: Cody, V, Luft, J.R, Pangborn, W, Gangjee, A, Queener, S.F. Deposit date: 2004-01-14 Release date: 2004-03-30 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structure determination of tetrahydroquinazoline antifolates in complex with human and Pneumocystis carinii dihydrofolate reductase: correlations between enzyme selectivity and stereochemistry. Acta Crystallogr.,Sect.D, 60, 2004
1RX4	DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH 5,10-DIDEAZATETRAHYDROFOLATE AND 2'-MONOPHOSPHOADENOSINE 5'-DIPHOSPHORIBOSE Descriptor: 5,10-DIDEAZATETRAHYDROFOLIC ACID, BETA-MERCAPTOETHANOL, DIHYDROFOLATE REDUCTASE, ... Authors: Sawaya, M.R. Deposit date: 1996-09-19 Release date: 1997-01-11 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. Biochemistry, 36, 1997
1S3W	Structure Determination of Tetrahydroquinazoline Antifoaltes in Complex with Human and Pneumocystis carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry Descriptor: 6-(OCTAHYDRO-1H-INDOL-1-YLMETHYL)DECAHYDROQUINAZOLINE-2,4-DIAMINE, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Cody, V, Luft, J.R, Pangborn, W, Gangjee, A, Queener, S.F. Deposit date: 2004-01-14 Release date: 2004-03-30 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structure determination of tetrahydroquinazoline antifolates in complex with human and Pneumocystis carinii dihydrofolate reductase: correlations between enzyme selectivity and stereochemistry. Acta Crystallogr.,Sect.D, 60, 2004
1S3Y	Structure Determination of Tetrahydroquinazoline Antifolates in Complex with Human and Pneumocystis carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry Descriptor: 6-(OCTAHYDRO-1H-INDOL-1-YLMETHYL)DECAHYDROQUINAZOLINE-2,4-DIAMINE, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Cody, V, Luft, J.R, Pangborn, W, Gangjee, A, Queener, S.F. Deposit date: 2004-01-14 Release date: 2004-03-30 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Structure determination of tetrahydroquinazoline antifolates in complex with human and Pneumocystis carinii dihydrofolate reductase: correlations between enzyme selectivity and stereochemistry. Acta Crystallogr.,Sect.D, 60, 2004
1RC4	DIHYDROFOLATE REDUCTASE COMPLEXED WITH 5,10-DIDEAZATETRAHYDROFOLATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM) Descriptor: 5,10-DIDEAZATETRAHYDROFOLIC ACID, DIHYDROFOLATE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Sawaya, M.R, Kraut, J. Deposit date: 1996-11-25 Release date: 1997-03-12 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. Biochemistry, 36, 1997
1U70	Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22Arg Variant Mouse and Human Dihydrofolate Reductase Descriptor: Dihydrofolate reductase, METHOTREXATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Cody, V. Deposit date: 2004-08-02 Release date: 2005-02-01 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Understanding the role of Leu22 variants in methotrexate resistance: comparison of wild-type and Leu22Arg variant mouse and human dihydrofolate reductase ternary crystal complexes with methotrexate and NADPH. Acta Crystallogr.,Sect.D, 61, 2005
1RX7	STRUCTURE OF DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE Descriptor: DIHYDROFOLATE REDUCTASE, FOLIC ACID Authors: Sawaya, M.R. Deposit date: 1996-10-25 Release date: 1997-03-12 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. Biochemistry, 36, 1997
1RX1	DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (REDUCED FORM) Descriptor: CALCIUM ION, DIHYDROFOLATE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Sawaya, M.R. Deposit date: 1996-09-19 Release date: 1997-01-11 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2 Å) Cite: Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. Biochemistry, 36, 1997
1U72	Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22Arg Variant Mouse and Human Dihydrfolate Reductase Ternary Crystal Complexes with Methotrexate and NADPH Descriptor: Dihydrofolate reductase, METHOTREXATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Cody, V. Deposit date: 2004-08-02 Release date: 2005-02-01 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Understanding the role of Leu22 variants in methotrexate resistance: comparison of wild-type and Leu22Arg variant mouse and human dihydrofolate reductase ternary crystal complexes with methotrexate and NADPH. Acta Crystallogr.,Sect.D, 61, 2005
1RX2	DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH WITH FOLATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM) Descriptor: BETA-MERCAPTOETHANOL, DIHYDROFOLATE REDUCTASE, FOLIC ACID, ... Authors: Sawaya, M.R. Deposit date: 1996-09-19 Release date: 1997-01-11 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. Biochemistry, 36, 1997

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