3RDJ
| Rat PKC C2 domain Apo | Descriptor: | Protein kinase C alpha type | Authors: | Li, P. | Deposit date: | 2011-04-01 | Release date: | 2011-09-07 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Pb2+ as modulator of protein-membrane interactions. J.Am.Chem.Soc., 133, 2011
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3RPB
| THE C2B-DOMAIN OF RABPHILIN: STRUCTURAL VARIATIONS IN A JANUS-FACED DOMAIN | Descriptor: | RABPHILIN 3-A | Authors: | Ubach, J, Garcia, J, Nittler, M.P, Sudhof, T.C, Rizo, J. | Deposit date: | 1999-04-19 | Release date: | 1999-12-23 | Last modified: | 2022-03-16 | Method: | SOLUTION NMR | Cite: | Structure of the Janus-faced C2B domain of rabphilin. Nat.Cell Biol., 1, 1999
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1A25
| C2 DOMAIN FROM PROTEIN KINASE C (BETA) | Descriptor: | CALCIUM ION, O-PHOSPHOETHANOLAMINE, PROTEIN KINASE C (BETA) | Authors: | Sutton, R.B, Sprang, S.R. | Deposit date: | 1998-01-16 | Release date: | 1998-05-06 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structure of the protein kinase Cbeta phospholipid-binding C2 domain complexed with Ca2+. Structure, 6, 1998
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6TZ3
| Crystal Structure of Human Synaptotagmin 1 C2B without Ca2+ | Descriptor: | SULFATE ION, Synaptotagmin-1 | Authors: | Dominguez, M.J, Karmakar, S, Meyer, A.G, Sutton, R.B. | Deposit date: | 2019-08-09 | Release date: | 2020-05-13 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.17 Å) | Cite: | Molecular Basis for Synaptotagmin-1-Associated Neurodevelopmental Disorder. Neuron, 107, 2020
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6U41
| 1.7 angstrom structure of a pathogenic human Syt 1 C2B (D304G) | Descriptor: | SULFATE ION, Synaptotagmin-1 | Authors: | Dominguez, M.J, Bradberry, M.M, Chapman, E.R, Sutton, R.B. | Deposit date: | 2019-08-22 | Release date: | 2020-05-13 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Molecular Basis for Synaptotagmin-1-Associated Neurodevelopmental Disorder. Neuron, 107, 2020
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6U4U
| 1.3 A structure of a pathogenic human Syt 1 C2B (I368T) | Descriptor: | SULFATE ION, Synaptotagmin-1 | Authors: | Dominguez, M.J, Bradberry, M.M, Chapman, E.R, Sutton, R.B. | Deposit date: | 2019-08-26 | Release date: | 2020-05-13 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Molecular Basis for Synaptotagmin-1-Associated Neurodevelopmental Disorder. Neuron, 107, 2020
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1BCI
| C2 DOMAIN OF CYTOSOLIC PHOSPHOLIPASE A2, NMR, MINIMIZED AVERAGE STRUCTURE | Descriptor: | CALCIUM ION, CYTOSOLIC PHOSPHOLIPASE A2 | Authors: | Xu, G.Y, Mcdonagh, T, Yu, H.A, Nalefski, E.A, Clark, J.D, Cumming, D.A. | Deposit date: | 1998-04-30 | Release date: | 1998-11-25 | Last modified: | 2022-02-16 | Method: | SOLUTION NMR | Cite: | Solution structure and membrane interactions of the C2 domain of cytosolic phospholipase A2. J.Mol.Biol., 280, 1998
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5H4Z
| Crystal structure of S202G mutant of human SYT-5 C2A domain | Descriptor: | CALCIUM ION, CHLORIDE ION, Synaptotagmin-5 | Authors: | Qiu, X, Ge, J, Yan, X, Gao, Y, Teng, M, Niu, L. | Deposit date: | 2016-11-02 | Release date: | 2016-11-30 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.01 Å) | Cite: | Structural analysis of Ca(2+)-binding pocket of synaptotagmin 5 C2A domain Int. J. Biol. Macromol., 95, 2017
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5LO8
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6U4W
| 1.4 A structure of a pathogenic human Syt 1 C2B (D366E) | Descriptor: | SULFATE ION, Synaptotagmin-1 | Authors: | Dominguez, M.J, Bradberry, M.M, Chapman, E.R, Sutton, R.B. | Deposit date: | 2019-08-26 | Release date: | 2020-05-13 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Molecular Basis for Synaptotagmin-1-Associated Neurodevelopmental Disorder. Neuron, 107, 2020
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5YQ3
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5LOB
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5LOW
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1BYN
| SOLUTION STRUCTURE OF THE CALCIUM-BOUND FIRST C2-DOMAIN OF SYNAPTOTAGMIN I | Descriptor: | CALCIUM ION, PROTEIN (SYNAPTOTAGMIN I) | Authors: | Shao, X, Fernandez, I, Sudhof, T.C, Rizo, J. | Deposit date: | 1998-10-18 | Release date: | 1998-10-21 | Last modified: | 2022-02-16 | Method: | SOLUTION NMR | Cite: | Solution structures of the Ca2+-free and Ca2+-bound C2A domain of synaptotagmin I: does Ca2+ induce a conformational change? Biochemistry, 37, 1998
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8FAM
| Edited Octopus bimaculoides Synaptotagmin 1 C2A (I248V) at room temperature | Descriptor: | Synaptotagmin | Authors: | McNeme, S, Dominguez, M.J, Birk, M.A, Rosenthal, J.J, Sutton, R.B. | Deposit date: | 2022-11-28 | Release date: | 2023-07-19 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Temperature-dependent RNA editing in octopus extensively recodes the neural proteome. Cell, 186, 2023
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8FAF
| Unedited Octopus bimaculoides Synaptotagmin 1 C2A at room temperature | Descriptor: | Synaptotagmin | Authors: | McNeme, S, Dominguez, M.J, Birk, M.A, Rosenthal, J.C, Sutton, R.B. | Deposit date: | 2022-11-26 | Release date: | 2023-07-19 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Temperature-dependent RNA editing in octopus extensively recodes the neural proteome. Cell, 186, 2023
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5H4Y
| Crystal structure of human synaptotagmin 5 C2A domain | Descriptor: | ACETATE ION, CALCIUM ION, Synaptotagmin-5 | Authors: | Qiu, X, Gao, Y, Teng, M, Niu, L. | Deposit date: | 2016-11-02 | Release date: | 2016-11-30 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural analysis of Ca(2+)-binding pocket of synaptotagmin 5 C2A domain Int. J. Biol. Macromol., 95, 2017
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3L9B
| Crystal Structure of Rat Otoferlin C2A | Descriptor: | MAGNESIUM ION, Otoferlin | Authors: | Helfmann, S, Neumann, P. | Deposit date: | 2010-01-04 | Release date: | 2011-01-19 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | The crystal structure of the C2A domain of otoferlin reveals an unconventional top loop region. J.Mol.Biol., 406, 2011
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6ANJ
| Synaptotagmin-7, C2A domain | Descriptor: | ACETATE ION, CALCIUM ION, Synaptotagmin-7, ... | Authors: | Tomchick, D.R, Rizo, J, Voleti, R. | Deposit date: | 2017-08-13 | Release date: | 2017-09-20 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.698 Å) | Cite: | Exceptionally tight membrane-binding may explain the key role of the synaptotagmin-7 C2A domain in asynchronous neurotransmitter release. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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6ANK
| Synaptotagmin-7, C2A- and C2B-domains | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, Synaptotagmin-7 | Authors: | Tomchick, D.R, Rizo, J, Voleti, R. | Deposit date: | 2017-08-13 | Release date: | 2017-09-20 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.254 Å) | Cite: | Exceptionally tight membrane-binding may explain the key role of the synaptotagmin-7 C2A domain in asynchronous neurotransmitter release. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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3N5A
| Synaptotagmin-7, C2B-domain, calcium bound | Descriptor: | CALCIUM ION, Synaptotagmin-7 | Authors: | Tomchick, D.R, Rizo, J, Craig, T.K. | Deposit date: | 2010-05-24 | Release date: | 2010-09-29 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.441 Å) | Cite: | Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7. Plos One, 5, 2010
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6BTY
| Crystal structure of the PI3KC2alpha C2 domain in space group P41212 | Descriptor: | 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha | Authors: | Chen, K.-E, Collins, B.M. | Deposit date: | 2017-12-08 | Release date: | 2018-10-17 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.678 Å) | Cite: | Molecular Basis for Membrane Recruitment by the PX and C2 Domains of Class II Phosphoinositide 3-Kinase-C2 alpha. Structure, 26, 2018
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6BTZ
| Crystal structure of the PI3KC2alpha C2 domain in space group C121 | Descriptor: | 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, GLYCEROL, Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, ... | Authors: | Chen, K.-E, Collins, B.M. | Deposit date: | 2017-12-08 | Release date: | 2018-10-17 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Molecular Basis for Membrane Recruitment by the PX and C2 Domains of Class II Phosphoinositide 3-Kinase-C2 alpha. Structure, 26, 2018
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1UOV
| Calcium binding domain C2B | Descriptor: | CALCIUM ION, GLYCEROL, SYNAPTOTAGMIN I | Authors: | Cheng, Y, Sequeira, S.M, Sollner, T.H, Patel, D.J. | Deposit date: | 2003-09-24 | Release date: | 2004-09-09 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Crystallographic Identification of Ca2+ and Sr2+ Coordination Sites in Synaptotagmin I C2B Domain Protein Sci., 13, 2004
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1W15
| rat synaptotagmin 4 C2B domain in the presence of calcium | Descriptor: | CALCIUM ION, CHLORIDE ION, SODIUM ION, ... | Authors: | Dai, H, Shin, O.-H, Machius, M, Tomchick, D.R, Sudhof, T.C, Rizo, J. | Deposit date: | 2004-06-16 | Release date: | 2004-08-13 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Structural Basis for the Evolutionary Inactivation of Ca2+ Binding to Synaptotagmin 4 Nat.Struct.Mol.Biol., 11, 2004
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