PDB: 117 件ウェブページステータス検索Chemie searchBIRD

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6W8J	Structure of DNMT3A (R882H) in complex with CAG DNA 分子名称: CAG DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, ... 著者 Anteneh, H, Song, J. 登録日 2020-03-20 公開日 2020-04-15 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.445 Å) 主引用文献 Structural basis for impairment of DNA methylation by the DNMT3A R882H mutation. Nat Commun, 11, 2020
6W8V	Crystal structure of mouse DNMT1 in complex with ACG DNA 分子名称: ACG DNA (5'-D(*AP*CP*TP*TP*AP*(C49)P*GP*GP*AP*AP*GP*G)-3'), ACG DNA (5'-D(*CP*CP*TP*TP*CP*(5CM)P*GP*TP*AP*AP*GP*T)-3'), DNA (cytosine-5)-methyltransferase 1, ... 著者 Anteneh, H, Song, J. 登録日 2020-03-21 公開日 2020-07-08 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.12 Å) 主引用文献 DNMT1 activity, base flipping mechanism and genome-wide DNA methylation are regulated by the DNA sequence context Nat Commun, 2020
6W8W	Crystal structure of mouse DNMT1 in complex with CCG DNA 分子名称: CCG DNA (5'-D(*AP*CP*TP*TP*AP*(5CM)P*GP*GP*AP*AP*GP*G)-3'), CCG DNA (5'-D(*CP*CP*TP*TP*CP*(C49)P*GP*TP*AP*AP*GP*T)-3'), DNA (cytosine-5)-methyltransferase 1, ... 著者 Anteneh, H, Song, J. 登録日 2020-03-21 公開日 2020-07-08 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 DNMT1 activity, base flipping mechanism and genome-wide DNA methylation are regulated by the DNA sequence context Nat Commun, 2020
6X9I	Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA 分子名称: 1,2-ETHANEDIOL, DNA (5'-D(*GP*AP*GP*GP*CP*(5CM)P*GP*CP*CP*TP*GP*C)-3'), DNA (5'-D(*GP*CP*AP*GP*G)-R(P*(PYO))-D(P*GP*GP*CP*CP*TP*C)-3'), ... 著者 Pathuri, S, Horton, J.R, Cheng, X. 登録日 2020-06-02 公開日 2021-07-07 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia. Nat Cancer, 2, 2021
6X9J	Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Inhibitor GSK3830052 分子名称: 1,2-ETHANEDIOL, DNA (5'-D(*GP*AP*GP*GP*CP*(5CM)P*GP*CP*CP*TP*GP*C)-3'), DNA (5'-D(*GP*CP*AP*GP*G)-R(P*(PYO))-D(P*GP*GP*CP*CP*TP*C)-3'), ... 著者 Pathuri, S, Horton, J.R, Cheng, X. 登録日 2020-06-02 公開日 2021-07-07 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia. Nat Cancer, 2, 2021
6X9K	Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Inhibitor GSK3685032A 分子名称: (2R)-2-{[6-(4-aminopiperidin-1-yl)-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl}-2-phenylacetamide, 1,2-ETHANEDIOL, DNA (5'-D(*GP*AP*GP*GP*CP*(5CM)P*GP*CP*CP*TP*GP*C)-3'), ... 著者 Pathuri, S, Horton, J.R, Cheng, X. 登録日 2020-06-02 公開日 2021-07-07 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia. Nat Cancer, 2, 2021
7L4C	Crystal structure of the DRM2-CTT DNA complex 分子名称: DNA (5'-D(*AP*TP*TP*AP*TP*TP*AP*AP*TP*(C49)P*TP*TP*AP*AP*TP*TP*TP*A)-3'), DNA (5'-D(*TP*AP*AP*AP*TP*TP*AP*AP*GP*AP*TP*TP*AP*AP*TP*AP*AP*T)-3'), DNA (cytosine-5)-methyltransferase DRM2, ... 著者 Fang, J, Song, J. 登録日 2020-12-18 公開日 2021-08-04 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 Substrate deformation regulates DRM2-mediated DNA methylation in plants. Sci Adv, 7, 2021
7L4F	Crystal structure of the DRM2-CAT DNA complex 分子名称: 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, DNA (5'-D(*AP*TP*TP*CP*CP*TP*CP*CP*TP*(C49)P*AP*TP*CP*CP*TP*TP*TP*A)-3'), DNA (5'-D(*TP*AP*AP*AP*GP*GP*AP*TP*GP*AP*GP*GP*AP*GP*GP*AP*AP*T)-3'), ... 著者 Fang, J, Song, J. 登録日 2020-12-19 公開日 2021-08-04 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Substrate deformation regulates DRM2-mediated DNA methylation in plants. Sci Adv, 7, 2021
7L4H	Crystal structure of the DRM2-CTG DNA complex 分子名称: DNA (5'-D(*AP*TP*TP*CP*CP*TP*AP*AP*TP*(C49)P*TP*GP*AP*AP*TP*TP*TP*A)-3'), DNA (5'-D(*TP*AP*AP*AP*TP*TP*CP*AP*GP*AP*TP*TP*AP*GP*GP*AP*AP*T)-3'), DNA (cytosine-5)-methyltransferase DRM2, ... 著者 Fang, J, Song, J. 登録日 2020-12-19 公開日 2021-08-04 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.56 Å) 主引用文献 Substrate deformation regulates DRM2-mediated DNA methylation in plants. Sci Adv, 7, 2021
7L4K	Crystal structure of the DRM2-CCG DNA complex 分子名称: DNA (5'-D(*AP*TP*TP*CP*CP*TP*AP*AP*TP*(C49)P*CP*GP*AP*AP*TP*TP*TP*A)-3'), DNA (5'-D(*TP*AP*AP*AP*TP*TP*CP*GP*GP*AP*TP*TP*AP*GP*GP*AP*AP*T)-3'), DNA (cytosine-5)-methyltransferase DRM2, ... 著者 Fang, J, Song, J. 登録日 2020-12-19 公開日 2021-08-04 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.61 Å) 主引用文献 Substrate deformation regulates DRM2-mediated DNA methylation in plants. Sci Adv, 7, 2021
7L4M	Crystal structure of the DRM2-CCT DNA complex 分子名称: DNA (5'-D(*TP*AP*AP*AP*GP*GP*AP*GP*GP*AP*GP*GP*AP*GP*GP*AP*AP*T)-3'), DNA (5'-D(P*AP*TP*TP*CP*CP*TP*CP*CP*TP*(C49)P*CP*TP*CP*CP*TP*TP*TP*A)-3'), DNA (cytosine-5)-methyltransferase DRM2, ... 著者 Fang, J, Song, J. 登録日 2020-12-19 公開日 2021-08-04 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.805 Å) 主引用文献 Substrate deformation regulates DRM2-mediated DNA methylation in plants. Sci Adv, 7, 2021
7L4N	Crystal structure of the DRM2 (C397R)-CCG DNA complex 分子名称: DNA (5'-D(*AP*TP*TP*CP*CP*TP*AP*AP*TP*(C49)P*CP*GP*AP*AP*TP*TP*TP*A)-3'), DNA (5'-D(*TP*AP*AP*AP*TP*TP*CP*GP*GP*AP*TP*TP*AP*GP*GP*AP*AP*T)-3'), DNA (cytosine-5)-methyltransferase DRM2, ... 著者 Fang, J, Song, J. 登録日 2020-12-19 公開日 2021-08-04 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.247 Å) 主引用文献 Substrate deformation regulates DRM2-mediated DNA methylation in plants. Sci Adv, 7, 2021
7MHT	CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI/DNA COMPLEX 分子名称: 5'-D(P*CP*CP*AP*TP*GP*AP*GP*CP*TP*GP*AP*C)-3', 5'-D(P*GP*TP*CP*AP*GP*CP*GP*CP*AP*TP*GP*G)-3', CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI, ... 著者 O'Gara, M, Horton, J.R, Roberts, R.J, Cheng, X. 登録日 1998-08-05 公開日 1998-11-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.87 Å) 主引用文献 Structures of HhaI methyltransferase complexed with substrates containing mismatches at the target base. Nat.Struct.Biol., 5, 1998
7R76	Cryo-EM structure of DNMT5 in apo state 分子名称: DNA repair protein Rad8, ZINC ION 著者 Wang, J, Patel, D.J. 登録日 2021-06-24 公開日 2022-02-23 最終更新日 2022-03-30 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance. Mol.Cell, 82, 2022
7R77	Cryo-EM structure of DNMT5 binary complex with hemimethylated DNA 分子名称: DNA (5'-D(P*GP*TP*CP*AP*GP*(5CM)P*GP*CP*AP*TP*GP*G)-3'), DNA repair protein Rad8, ZINC ION 著者 Wang, J, Patel, D.J. 登録日 2021-06-24 公開日 2022-02-23 最終更新日 2022-03-30 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance. Mol.Cell, 82, 2022
7R78	cryo-EM structure of DNMT5 quaternary complex with hemimethylated DNA, AMP-PNP and SAH 分子名称: DNA (5'-D(*TP*GP*CP*GP*CP*TP*GP*AP*CP*A)-3'), DNA (5'-D(P*CP*AP*GP*(5CM)P*GP*CP*AP*T)-3'), DNA repair protein Rad8, ... 著者 Wang, J, Patel, D.J. 登録日 2021-06-24 公開日 2022-02-23 最終更新日 2022-03-30 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance. Mol.Cell, 82, 2022
7SFC	Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Inhibitor GSK3735967A 分子名称: 1,2-ETHANEDIOL, DNA (12-MER), DNA (cytosine-5)-methyltransferase 1, ... 著者 Horton, J.R, Pathuri, S, Cheng, X. 登録日 2021-10-03 公開日 2022-03-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Structural characterization of dicyanopyridine containing DNMT1-selective, non-nucleoside inhibitors. Structure, 30, 2022
7SFD	Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Inhibitor GSK3543105A 分子名称: (2S)-2-({3,5-dicyano-4-ethyl-6-[4-(2-hydroxyethyl)-1,4-diazepan-1-yl]pyridin-2-yl}sulfanyl)-2-phenylacetamide, 1,2-ETHANEDIOL, DNA (12-MER), ... 著者 Horton, J.R, Pathuri, S, Cheng, X. 登録日 2021-10-03 公開日 2022-03-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Structural characterization of dicyanopyridine containing DNMT1-selective, non-nucleoside inhibitors. Structure, 30, 2022
7SFE	Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Inhibitor GSK3830334A 分子名称: (2R)-2-{[6-(4-aminopiperidin-1-yl)-3,5-dicyano-4-ethylpyridin-2-yl]amino}-2-phenylacetamide, 1,2-ETHANEDIOL, DNA (12-MER), ... 著者 Horton, J.R, Pathuri, S, Cheng, X. 登録日 2021-10-03 公開日 2022-03-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Structural characterization of dicyanopyridine containing DNMT1-selective, non-nucleoside inhibitors. Structure, 30, 2022
7SFF	Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Inhibitor GSK3852279B 分子名称: (2R)-2-{[6-(4-aminopiperidin-1-yl)-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl}-2-[4-(trifluoromethyl)phenyl]acetamide, 1,2-ETHANEDIOL, DNA (12-MER), ... 著者 Horton, J.R, Pathuri, S, Cheng, X. 登録日 2021-10-03 公開日 2022-03-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Structural characterization of dicyanopyridine containing DNMT1-selective, non-nucleoside inhibitors. Structure, 30, 2022
7SFG	Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Cofactor SAM 分子名称: 1,2-ETHANEDIOL, DNA (cytosine-5)-methyltransferase 1, DNA Strand 1, ... 著者 Horton, J.R, Pathuri, S, Cheng, X. 登録日 2021-10-03 公開日 2022-03-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.43 Å) 主引用文献 Structural characterization of dicyanopyridine containing DNMT1-selective, non-nucleoside inhibitors. Structure, 30, 2022
7T02	Cryo-EM structure of DNMT5 pseudo-ternary complex solved by incubation with hemimethylated DNA and SAM 分子名称: DNA (5'-D(*CP*CP*AP*TP*GP*CP*GP*CP*TP*GP*AP*CP*A)-3'), DNA (5'-D(P*GP*TP*CP*AP*GP*(5CM)P*GP*CP*AP*TP*GP*G)-3'), DNA repair protein Rad8, ... 著者 Wang, J, Patel, D.J. 登録日 2021-11-29 公開日 2022-02-23 最終更新日 2024-02-28 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance. Mol.Cell, 82, 2022
7UBU	Crystal structure of ZMET2 in complex with hemimethylated CAG DNA and a histone H3Kc9me2 peptide 分子名称: 5MC SSDNA, C49 SSDNA, DNA (cytosine-5)-methyltransferase 1, ... 著者 Fang, J, Song, J. 登録日 2022-03-15 公開日 2022-06-08 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 Mechanistic basis for maintenance of CHG DNA methylation in plants. Nat Commun, 13, 2022
7V0E	Crystal structure of the macro-oligomeric form of DNMT3B methyltransferase domain. 分子名称: DNA (cytosine-5)-methyltransferase 3B, S-ADENOSYL-L-HOMOCYSTEINE 著者 Gao, L, Lu, J, Song, J. 登録日 2022-05-10 公開日 2022-06-22 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.27016377 Å) 主引用文献 Structure of DNMT3B homo-oligomer reveals vulnerability to impairment by ICF mutations. Nat Commun, 13, 2022
7X9D	DNMT3B in complex with harmine 分子名称: 7-METHOXY-1-METHYL-9H-BETA-CARBOLINE, DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B 著者 Cho, C.-C, Yuan, H.S. 登録日 2022-03-15 公開日 2023-03-15 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.08 Å) 主引用文献 Mechanistic Insights into Harmine-Mediated Inhibition of Human DNA Methyltransferases and Prostate Cancer Cell Growth. Acs Chem.Biol., 18, 2023

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