7SFD

Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Inhibitor GSK3543105A

This is a non-PDB format compatible entry.

Summary for 7SFD

• Entry DOI: 10.2210/pdb7sfd/pdb
• Descriptor: DNA (cytosine-5)-methyltransferase 1, DNA (12-MER), S-ADENOSYL-L-HOMOCYSTEINE, ... (9 entities in total)
• Functional Keywords: epigentics, dna methytransferase fold, maintenance methylation, inhibition, dna binding protein, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 107497.53

Authors

Horton, J.R.,Pathuri, S.,Cheng, X. (deposition date: 2021-10-03, release date: 2022-03-30, Last modification date: 2023-10-18)

• Primary citation: Horton, J.R.,Pathuri, S.,Wong, K.,Ren, R.,Rueda, L.,Fosbenner, D.T.,Heerding, D.A.,McCabe, M.T.,Pappalardi, M.B.,Zhang, X.,King, B.W.,Cheng, X.; Structural characterization of dicyanopyridine containing DNMT1-selective, non-nucleoside inhibitors.; Structure, 30:793-802.e5, 2022; PubMed: 35395178; DOI: 10.1016/j.str.2022.03.009

Experimental method

X-RAY DIFFRACTION (2.09 Å)