6W8V

Crystal structure of mouse DNMT1 in complex with ACG DNA

Summary for 6W8V

• Entry DOI: 10.2210/pdb6w8v/pdb
• Descriptor: DNA (cytosine-5)-methyltransferase 1, ACG DNA (5'-D(*CP*CP*TP*TP*CP*(5CM)P*GP*TP*AP*AP*GP*T)-3'), ACG DNA (5'-D(*AP*CP*TP*TP*AP*(C49)P*GP*GP*AP*AP*GP*G)-3'), ... (5 entities in total)
• Functional Keywords: dna methylation, dnmt1, epigenetics, transferase, transferase-dna complex, transferase/dna
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 6
• Total formula weight: 213797.40

Authors

Anteneh, H.,Song, J. (deposition date: 2020-03-21, release date: 2020-07-08, Last modification date: 2023-10-18)

• Primary citation: Adam, S.,Anteneh, H.,Hornisch, M.,Wagner, V.,Lu, J.,Radde, N.E.,Bashtrykov, P.,Song, J.,Jeltsch, A.; DNMT1 activity, base flipping mechanism and genome-wide DNA methylation are regulated by the DNA sequence context; Nat Commun, 2020

Experimental method

X-RAY DIFFRACTION (3.12 Å)