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1HMY	CRYSTAL STRUCTURE OF THE HHAI DNA METHYLTRANSFERASE COMPLEXED WITH S-ADENOSYL-L-METHIONINE Descriptor: HaeIII METHYLTRANSFERASE, S-ADENOSYLMETHIONINE Authors: Cheng, X. Deposit date: 1993-08-05 Release date: 1993-10-31 Last modified: 2012-02-01 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-L-methionine. Cell(Cambridge,Mass.), 74, 1993
6BRR	Crystal structure of DNMT3A (R836A)-DNMT3L in complex with DNA containing two CpG sites Descriptor: DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, ... Authors: Zhang, Z.M, Song, J. Deposit date: 2017-11-30 Release date: 2018-01-31 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.97 Å) Cite: Structural basis for DNMT3A-mediated de novo DNA methylation. Nature, 554, 2018
6W8D	Structure of DNMT3A (R882H) in complex with CGT DNA Descriptor: CGT DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, ... Authors: Anteneh, H, Song, J. Deposit date: 2020-03-20 Release date: 2020-04-15 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.598 Å) Cite: Structural basis for impairment of DNA methylation by the DNMT3A R882H mutation. Nat Commun, 11, 2020
7V0E	Crystal structure of the macro-oligomeric form of DNMT3B methyltransferase domain. Descriptor: DNA (cytosine-5)-methyltransferase 3B, S-ADENOSYL-L-HOMOCYSTEINE Authors: Gao, L, Lu, J, Song, J. Deposit date: 2022-05-10 Release date: 2022-06-22 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.27016377 Å) Cite: Structure of DNMT3B homo-oligomer reveals vulnerability to impairment by ICF mutations. Nat Commun, 13, 2022
8C58	CpG specific M.MpeI methyltransferase crystallized in the presence of 5-hydroxycytosine and 5-methylcytosine containing dsDNA Descriptor: CARBONATE ION, Cytosine-specific methyltransferase, DNA (5'-D(*CP*CP*AP*CP*AP*TP*GP*(5OC)P*GP*CP*TP*GP*AP*A)-3'), ... Authors: Wojciechowski, M, Czapinska, H, Krwawicz, J, Rafalski, D, Bochtler, M. Deposit date: 2023-01-06 Release date: 2024-01-17 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Cytosine analogues as DNA methyltransferase substrates and inhibitors To Be Published
8C57	CpG specific M.MpeI methyltransferase crystallized in the presence of 5,6-dihydro-5-azacytosine (converted to 5m-dhaC) and 5-methylcytosine containing dsDNA Descriptor: CARBONATE ION, Cytosine-specific methyltransferase, DNA (5'-D(*CP*CP*AP*CP*AP*TP*GP*(5MA)P*GP*CP*TP*GP*AP*A)-3'), ... Authors: Wojciechowski, M, Czapinska, H, Krwawicz, J, Rafalski, D, Bochtler, M. Deposit date: 2023-01-06 Release date: 2024-01-17 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Cytosine analogues as DNA methyltransferase substrates and inhibitors To Be Published
8C56	CpG specific M.MpeI methyltransferase crystallized in the presence of 2'-deoxy-5-methylzebularine (5mZ) and 5-methylcytosine containing dsDNA Descriptor: Cytosine-specific methyltransferase, DNA (5'-D(*CP*CP*AP*CP*AP*TP*GP*(5PY)P*GP*CP*TP*GP*AP*A)-3'), DNA (5'-D(*GP*TP*TP*CP*AP*GP*(5CM)P*GP*CP*AP*TP*GP*TP*G)-3'), ... Authors: Wojciechowski, M, Czapinska, H, Krwawicz, J, Rafalski, D, Bochtler, M. Deposit date: 2023-01-06 Release date: 2024-01-17 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Cytosine analogues as DNA methyltransferase substrates and inhibitors To Be Published
8C59	CpG specific M.MpeI methyltransferase crystallized in the presence of 5-bromocytosine (converted to 5mC) and 5-methylcytosine containing dsDNA Descriptor: CARBONATE ION, CITRIC ACID, Cytosine-specific methyltransferase, ... Authors: Wojciechowski, M, Czapinska, H, Krwawicz, J, Rafalski, D, Bochtler, M. Deposit date: 2023-01-06 Release date: 2024-01-17 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Cytosine analogues as DNA methyltransferase substrates and inhibitors To Be Published
2QRV	Structure of Dnmt3a-Dnmt3L C-terminal domain complex Descriptor: DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, S-ADENOSYL-L-HOMOCYSTEINE Authors: Jia, D, Cheng, X. Deposit date: 2007-07-29 Release date: 2007-12-04 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.89 Å) Cite: Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation. Nature, 449, 2007
7X9D	DNMT3B in complex with harmine Descriptor: 7-METHOXY-1-METHYL-9H-BETA-CARBOLINE, DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B Authors: Cho, C.-C, Yuan, H.S. Deposit date: 2022-03-15 Release date: 2023-03-15 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (3.08 Å) Cite: Mechanistic Insights into Harmine-Mediated Inhibition of Human DNA Methyltransferases and Prostate Cancer Cell Growth. Acs Chem.Biol., 18, 2023
2UYH	HhaI DNA methyltransferase S87Q-Q237S mutant complex with 13mer GCGC- GMGC oligonucleotide and SAH Descriptor: 5'-D(*GP*TP*CP*AP*GP*CP*GP*CP*AP*TP *CP*C)-3', 5'-D(*TP*GP*GP*AP*TP*G*5CMP*GP*CP*TP*GP *AP*C)-3', MODIFICATION METHYLASE HHAI, ... Authors: Daujotyte, D, Grazulis, S. Deposit date: 2007-04-06 Release date: 2008-05-27 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.63 Å) Cite: HhaI DNA Methyltransferase S87Q-Q237S Mutant Complex with 13mer Gcgc-Gmgc Oligonucleotide and Sah To be Published
2UYC	HhaI DNA methyltransferase R163N mutant complex with 13mer GCGC-GMGC oligonucleotide and SAH Descriptor: 5'-D(*GP*TP*CP*AP*GP*CP*GP*CP*AP*TP *CP*C)-3', 5'-D(*TP*GP*GP*AP*TP*GP*5CMP*GP*CP*TP *GP*AP*C)-3', GLYCEROL, ... Authors: Daujotyte, D, Grazulis, S. Deposit date: 2007-04-03 Release date: 2008-05-27 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2 Å) Cite: HhaI DNA Methyltransferase R163N Mutant Complex with 13mer Gcgc-Gmgc Oligonucleotide and Sah To be Published
2UZ4	HhaI DNA methyltransferase R165N mutant complex with 13mer GCGC-GMGC oligonucleotide and SAH Descriptor: 5'-D(*GP*TP*CP*AP*GP*CP*GP*CP*AP*TP *CP*C)-3', 5'-D(*TP*GP*GP*AP*TP*GP*5CMP*GP*CP*TP*GP *AP*C)-3', GLYCEROL, ... Authors: Daujotyte, D, Leinartaite, L, Grazulis, S. Deposit date: 2007-04-25 Release date: 2008-06-03 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: DNA Methyltransferase R165N Mutant To be Published
2C7P	HhaI DNA methyltransferase complex with oligonucleotide containing 2- aminopurine opposite to the target base (GCGC:GMPC) and SAH Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-D(*G*GP*AP*TP*GP*(5CM*2PR)*CP*TP*GP*AP*C)-3', 5'-D(*G*TP*CP*AP*GP*CP*GP*CP*AP*TP*CP*C)-3', ... Authors: Neely, R.K, Daujotyte, D, Grazulis, S, Magennis, S.W, Dryden, D.T.F, Klimasauskas, S, Jones, A.C. Deposit date: 2005-11-25 Release date: 2005-12-14 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Time-Resolved Fluorescence of 2-Aminopurine as a Probe of Base Flipping in M.HhaI-DNA Complexes. Nucleic Acids Res., 33, 2005
2C7R	HhaI DNA methyltransferase (T250G mutant) complex with oligonucleotide containing 2-aminopurine as a target base (GPGC:GMGC) and SAH Descriptor: 5'-D(*G*GP*AP*TP*GP*(5CM)*GP*CP*TP*GP*AP*C)-3', 5'-D(*G*TP*CP*AP*GP*(2PR)*GP*CP*AP*TP*CP*C)-3', GLYCEROL, ... Authors: Daujotyte, D, Grazulis, S. Deposit date: 2005-11-27 Release date: 2005-12-14 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Time-Resolved Fluorescence of 2-Aminopurine as a Probe of Base Flipping in M.HhaI-DNA Complexes. Nucleic Acids Res., 33, 2005
2C7O	HhaI DNA methyltransferase complex with 13mer oligonucleotide containing 2-aminopurine adjacent to the target base (PCGC:GMGC) and SAH Descriptor: 5'-D(*T*GP*GP*AP*TP*GP*(5CM)*GP*CP*TP*GP*AP *C)-3', 5'-D(*T*GP*TP*CP*AP*(2PR)*CP*GP*CP*AP*TP*CP *C)-3', MODIFICATION METHYLASE HHAI, ... Authors: Daujotyte, D, Grazulis, S. Deposit date: 2005-11-25 Release date: 2005-12-14 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Time-Resolved Fluorescence of 2-Aminopurine as a Probe of Base Flipping in M.HhaI-DNA Complexes. Nucleic Acids Res., 33, 2005
2C7Q	HhaI DNA methyltransferase complex with oligonucleotide containing 2- aminopurine outside the recognition sequence (paired with G) and SAH Descriptor: 5'-D(*T*GP*GP*(2PR)*GP*GP*(5CM)*GP*CP*TP*GP* AP*C)-3', 5'-D(*T*GP*TP*CP*AP*GP*CP*GP*CP*CP*GP*CP*C)-3', CITRIC ACID, ... Authors: Daujotyte, D, Grazulis, S. Deposit date: 2005-11-27 Release date: 2005-12-14 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Time-Resolved Fluorescence of 2-Aminopurine as a Probe of Base Flipping in M.HhaI-DNA Complexes Nucleic Acids Res., 33, 2005
4DKJ	CpG specific methyltransferase in complex with target DNA Descriptor: Cytosine-specific methyltransferase, DNA (5'-D(*CP*CP*AP*CP*AP*TP*GP*(C37)P*GP*CP*TP*GP*AP*A)-3'), DNA (5'-D(*GP*TP*TP*CP*AP*GP*(5CM)P*GP*CP*AP*TP*GP*TP*G)-3'), ... Authors: Wojciechowski, M, Czapinska, H, Bochtler, M. Deposit date: 2012-02-03 Release date: 2012-12-05 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.15 Å) Cite: CpG underrepresentation and the bacterial CpG-specific DNA methyltransferase M.MpeI. Proc.Natl.Acad.Sci.USA, 110, 2013
8T1U	Crystal structure of the DRM2-CTA DNA complex Descriptor: DNA (5'-D(P*AP*TP*TP*AP*TP*TP*AP*AP*TP*(C49)P*TP*AP*AP*AP*TP*TP*TP*A)-3'), DNA (5'-D(P*TP*AP*AP*AP*TP*TP*TP*AP*GP*AP*TP*TP*AP*AP*TP*AP*AP*T)-3'), DNA (cytosine-5)-methyltransferase DRM2, ... Authors: Chen, J, Lu, J, Song, J. Deposit date: 2023-06-03 Release date: 2023-11-22 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.91 Å) Cite: DNA conformational dynamics in the context-dependent non-CG CHH methylation by plant methyltransferase DRM2. J.Biol.Chem., 299, 2023
8TDR	Crystal structure of the methyltransferase domain of DNMT3A homotetramer Descriptor: DNA (cytosine-5)-methyltransferase 3A, S-ADENOSYL-L-HOMOCYSTEINE Authors: Lu, J.W, Song, J.K. Deposit date: 2023-07-04 Release date: 2024-03-13 Method: X-RAY DIFFRACTION (3.32 Å) Cite: Crystal structure of the homo-tetrameric DNMT3A methyltransferase domain To Be Published
8TE4	Crystal structure of the methyltransferase domain of R882H/N879A DNMT3A homotetramer Descriptor: DNA (cytosine-5)-methyltransferase 3A, GLYCEROL, S-ADENOSYL-L-HOMOCYSTEINE Authors: Lu, J.W, Song, J.K. Deposit date: 2023-07-05 Release date: 2024-03-13 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Crystal structure of the methyltransferase domain of R882H/N879A DNMT3A homotetramer To Be Published
8TE3	Crystal structure of the methyltransferase domain of R882C/R676K DNMT3A homotetramer Descriptor: DNA (cytosine-5)-methyltransferase 3A, S-ADENOSYL-L-HOMOCYSTEINE Authors: Lu, J.W, Song, J.K. Deposit date: 2023-07-05 Release date: 2024-03-13 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Crystal structure of the homo-tetrameric DNMT3A methyltransferase domain(R882C/R676K) To Be Published
8TE1	Crystal structure of the methyltransferase domain of R882H/R676K DNMT3A homotetramer Descriptor: DNA (cytosine-5)-methyltransferase 3A, GLYCEROL, L(+)-TARTARIC ACID, ... Authors: Lu, J.W, Song, J.K. Deposit date: 2023-07-05 Release date: 2024-03-13 Method: X-RAY DIFFRACTION (2.48 Å) Cite: Crystal structure of the methyltransferase domain of R882H/R676K DNMT3A homotetramer To Be Published
2HMY	BINARY COMPLEX OF HHAI METHYLTRANSFERASE WITH ADOMET FORMED IN THE PRESENCE OF A SHORT NONPSECIFIC DNA OLIGONUCLEOTIDE Descriptor: PROTEIN (CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI), S-ADENOSYLMETHIONINE Authors: O'Gara, M, Zhang, X, Roberts, R.J, Cheng, X. Deposit date: 1999-02-08 Release date: 1999-03-19 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.61 Å) Cite: Structure of a binary complex of HhaI methyltransferase with S-adenosyl-L-methionine formed in the presence of a short non-specific DNA oligonucleotide. J.Mol.Biol., 287, 1999
6KDL	Crystal structure of human DNMT3B-DNMT3L complex (I) Descriptor: DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, S-ADENOSYL-L-HOMOCYSTEINE Authors: Lin, C.-C, Chen, Y.-P, Yang, W.-Z, Shen, C.-K, Yuan, H.S. Deposit date: 2019-07-02 Release date: 2020-02-19 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.274 Å) Cite: Structural insights into CpG-specific DNA methylation by human DNA methyltransferase 3B. Nucleic Acids Res., 48, 2020

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