8A12
| Plasmodium falciparum Myosin A full-length, post-rigor state complexed to Mg.ATP-gamma-S | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Moussaoui, D, Robblee, J.P, Auguin, D, Fisher, F, Fagnant, P.M, MacFarlane, J.E, Mueller-Dieckmann, C, Baum, J, Robert-Paganin, J, Trybus, K.M, Houdusse, A. | 登録日 | 2022-05-31 | 公開日 | 2023-06-21 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Mechanism of small molecule inhibition of Plasmodium falciparum myosin A informs antimalarial drug design. Nat Commun, 14, 2023
|
|
6FSA
| Beta-Cardiac myosin post-rigor | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, FORMIC ACID, ... | 著者 | Robert-Paganin, J, Auguin, D, Houdusse, A. | 登録日 | 2018-02-19 | 公開日 | 2018-07-25 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | 主引用文献 | Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition. Nat Commun, 9, 2018
|
|
7KOG
| Lethocerus Myosin II complete coiled-coil domain resolved in its native environment | 分子名称: | Myosin heavy chain isoform Mhc_X1 | 著者 | Rahmani, H, Hu, Z, Daneshparvar, N, Taylor, D, Taylor, K.A. | 登録日 | 2020-11-09 | 公開日 | 2021-03-24 | 最終更新日 | 2021-04-14 | 実験手法 | ELECTRON MICROSCOPY (4.25 Å) | 主引用文献 | The myosin II coiled-coil domain atomic structure in its native environment. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7DHW
| Crystal structure of myosin-XI motor domain in complex with ADP-ALF4 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | 著者 | Suzuki, K, Haraguchi, T, Tamanaha, M, Yoshimura, K, Imi, T, Tominaga, M, Sakayama, H, Nishiyama, T, Ito, K, Murata, T. | 登録日 | 2020-11-17 | 公開日 | 2021-05-19 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.84 Å) | 主引用文献 | Discovery of ultrafast myosin, its amino acid sequence, and structural features. Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
8ACT
| structure of the human beta-cardiac myosin folded-back off state | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Myosin light chain 3, ... | 著者 | Grinzato, A, Kandiah, E, Robert-Paganin, J, Auguin, D, Kikuti, C, Nandwani, N, Moussaoui, D, Pathak, D, Ruppel, K.M, Spudich, J.A, Houdusse, A. | 登録日 | 2022-07-06 | 公開日 | 2023-06-07 | 最終更新日 | 2023-08-30 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Cryo-EM structure of the folded-back state of human beta-cardiac myosin. Nat Commun, 14, 2023
|
|
1QVI
| Crystal structure of scallop myosin S1 in the pre-power stroke state to 2.6 Angstrom resolution: flexibility and function in the head | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, MAGNESIUM ION, ... | 著者 | Gourinath, S, Himmel, D.M, Brown, J.H, Reshetnikova, L, Szent-Gyrgyi, A.G, Cohen, C. | 登録日 | 2003-08-27 | 公開日 | 2003-12-16 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | 主引用文献 | Crystal structure of scallop Myosin s1 in the pre-power stroke state to 2.6 a resolution: flexibility and function in the head. Structure, 11, 2003
|
|
5T45
| Chicken smooth muscle myosin motor domain co-crystallized with the specific CK-571 inhibitor, MgADP.BeFx form | 分子名称: | 4-{[(2-chloro-3-fluorobenzyl)carbamoyl](methyl)amino}-3,4-dideoxy-5-O-(isoquinolin-3-ylcarbamoyl)-D-erythro-pentitol, ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, ... | 著者 | Sirigu, S, Planelles-Herrero, V.J, Hartman, J, Houdusse, A. | 登録日 | 2016-08-29 | 公開日 | 2016-11-16 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Highly selective inhibition of myosin motors provides the basis of potential therapeutic application. Proc. Natl. Acad. Sci. U.S.A., 113, 2016
|
|
5TBY
| HUMAN BETA CARDIAC HEAVY MEROMYOSIN INTERACTING-HEADS MOTIF OBTAINED BY HOMOLOGY MODELING (USING SWISS-MODEL) OF HUMAN SEQUENCE FROM APHONOPELMA HOMOLOGY MODEL (PDB-3JBH), RIGIDLY FITTED TO HUMAN BETA-CARDIAC NEGATIVELY STAINED THICK FILAMENT 3D-RECONSTRUCTION (EMD-2240) | 分子名称: | Myosin light chain 3, Myosin regulatory light chain 2, ventricular/cardiac muscle isoform, ... | 著者 | ALAMO, L, WARE, J.S, PINTO, A, GILLILAN, R.E, SEIDMAN, J.G, SEIDMAN, C.E, PADRON, R. | 登録日 | 2016-09-13 | 公開日 | 2017-06-07 | 最終更新日 | 2020-01-08 | 実験手法 | ELECTRON MICROSCOPY (20 Å) | 主引用文献 | Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes. Elife, 6, 2017
|
|
2JHR
| Crystal structure of myosin-2 motor domain in complex with ADP- metavanadate and pentabromopseudilin | 分子名称: | ADP METAVANADATE, MAGNESIUM ION, MYOSIN-2 HEAVY CHAIN, ... | 著者 | Fedorov, R, Boehl, M, Tsiavaliaris, G, Hartmann, F.K, Baruch, P, Brenner, B, Martin, R, Knoelker, H.J, Gutzeit, H.O, Manstein, D.J. | 登録日 | 2008-03-25 | 公開日 | 2009-01-13 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | The Mechanism of Pentabromopseudilin Inhibition of Myosin Motor Activity. Nat.Struct.Mol.Biol., 16, 2009
|
|
2JJ9
| Crystal structure of myosin-2 in complex with ADP-metavanadate | 分子名称: | ADP METAVANADATE, MAGNESIUM ION, MYOSIN-2 HEAVY CHAIN | 著者 | Fedorov, R, Boehl, M, Tsiavaliaris, G, Hartmann, F.K, Baruch, P, Brenner, B, Martin, R, Knoelker, H.J, Gutzeit, H.O, Manstein, D.J. | 登録日 | 2008-03-25 | 公開日 | 2009-01-13 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | The Mechanism of Pentabromopseudilin Inhibition of Myosin Motor Activity. Nat.Struct.Mol.Biol., 16, 2009
|
|
7MF3
| Structure of the autoinhibited state of smooth muscle myosin-2 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Myosin light polypeptide 6, ... | 著者 | Heissler, S.M, Arora, A.S, Billington, N, Sellers, J.R, Chinthalapudi, K. | 登録日 | 2021-04-08 | 公開日 | 2022-01-05 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Cryo-EM structure of the autoinhibited state of myosin-2. Sci Adv, 7, 2021
|
|
5M05
| Chicken smooth muscle myosin motor domain co-crystallized with the specific CK-571 inhibitor, MgADP form | 分子名称: | 4-{[(2-chloro-3-fluorobenzyl)carbamoyl](methyl)amino}-3,4-dideoxy-5-O-(isoquinolin-3-ylcarbamoyl)-D-erythro-pentitol, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Sirigu, S, Hartman, J, Houdusse, A. | 登録日 | 2016-10-03 | 公開日 | 2016-11-16 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.675 Å) | 主引用文献 | Highly selective inhibition of myosin motors provides the basis of potential therapeutic application. Proc. Natl. Acad. Sci. U.S.A., 113, 2016
|
|
8CDQ
| Plasmodium falciparum Myosin A full-length, post-rigor state complexed to the inhibitor KNX-002 and Mg.ATP-gamma-S | 分子名称: | 1,2-ETHANEDIOL, 1-(4-methoxyphenyl)-~{N}-[(3-thiophen-2-yl-1~{H}-pyrazol-4-yl)methyl]cyclopropan-1-amine, GLYCEROL, ... | 著者 | Moussaoui, D, Robblee, J.P, Robert-Paganin, J, Auguin, D, Fisher, F, Fagnant, P.M, MacFarlane, J.E, Schaletzky, J, Wehri, E, Mueller-Dieckmann, C, Baum, J, Trybus, K.M, Houdusse, A. | 登録日 | 2023-01-31 | 公開日 | 2023-06-21 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | Mechanism of small molecule inhibition of Plasmodium falciparum myosin A informs antimalarial drug design. Nat Commun, 14, 2023
|
|
1S5G
| Structure of Scallop myosin S1 reveals a novel nucleotide conformation | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, MAGNESIUM ION, ... | 著者 | Risal, D, Gourinath, S, Himmel, D.M, Szent-Gyorgyi, A.G, Cohen, C. | 登録日 | 2004-01-20 | 公開日 | 2004-06-22 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Myosin subfragment 1 structures reveal a partially bound nucleotide and a complex salt bridge that helps couple nucleotide and actin binding. Proc.Natl.Acad.Sci.Usa, 101, 2004
|
|
1SR6
| Structure of nucleotide-free scallop myosin S1 | 分子名称: | CALCIUM ION, MAGNESIUM ION, Myosin essential light chain, ... | 著者 | Risal, D, Gourinath, S, Himmel, D.M, Szent-Gyorgyi, A.G, Cohen, C. | 登録日 | 2004-03-22 | 公開日 | 2004-06-15 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Myosin subfragment 1 structures reveal a partially bound nucleotide and a complex salt bridge that helps couple nucleotide and actin binding. Proc.Natl.Acad.Sci.Usa, 101, 2004
|
|
5V7X
| Crystal Structure of Myosin 1b residues 1-728 with bound sulfate and Calmodulin | 分子名称: | Calmodulin-1, SULFATE ION, Unconventional myosin-Ib | 著者 | Zwolak, A, Shuman, H, Dominguez, R, Ostap, E.M. | 登録日 | 2017-03-20 | 公開日 | 2018-02-28 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (3.141 Å) | 主引用文献 | High-resolution cryo-EM structures of actin-bound myosin states reveal the mechanism of myosin force sensing. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
|
|
5N69
| Cardiac muscle myosin S1 fragment in the pre-powerstroke state co-crystallized with the activator Omecamtiv Mecarbil | 分子名称: | 3,3',3''-phosphanetriyltripropanoic acid, ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ... | 著者 | Planelles-Herrero, V.J, Hartman, J.J, Robert-Paganin, J, Malik, F.I, Houdusse, A. | 登録日 | 2017-02-14 | 公開日 | 2017-08-16 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil. Nat Commun, 8, 2017
|
|
2MYS
| |
2BKH
| Myosin VI nucleotide-free (MDInsert2) crystal structure | 分子名称: | CALCIUM ION, CALMODULIN, GLYCEROL, ... | 著者 | Menetrey, J, Bahloul, A, Yengo, C, Wells, A, Morris, C, Sweeney, H.L, Houdusse, A. | 登録日 | 2005-02-16 | 公開日 | 2005-06-07 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | The Structure of the Myosin Vi Motor Reveals the Mechanism of Directionality Reversal Nature, 435, 2005
|
|
1FMV
| CRYSTAL STRUCTURE OF THE APO MOTOR DOMAIN OF DICTYOSTELLIUM MYOSIN II | 分子名称: | CHLORIDE ION, MYOSIN II HEAVY CHAIN | 著者 | Bauer, C.B, Holden, H.M, Thoden, J.B, Smith, R, Rayment, I. | 登録日 | 2000-08-18 | 公開日 | 2000-11-22 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | X-ray structures of the apo and MgATP-bound states of Dictyostelium discoideum myosin motor domain. J.Biol.Chem., 275, 2000
|
|
2BKI
| Myosin VI nucleotide-free (MDinsert2-IQ) crystal structure | 分子名称: | CALCIUM ION, CALMODULIN, SULFATE ION, ... | 著者 | Menetrey, J, Bahloul, A, Yengo, C, Wells, A, Morris, C, Sweeney, H.L, Houdusse, A. | 登録日 | 2005-02-16 | 公開日 | 2005-06-07 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | The Structure of the Myosin Vi Motor Reveals the Mechanism of Directionality Reversal Nature, 435, 2005
|
|
1FMW
| CRYSTAL STRUCTURE OF THE MGATP COMPLEX FOR THE MOTOR DOMAIN OF DICTYOSTELIUM MYOSIN II | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, MYOSIN II HEAVY CHAIN | 著者 | Bauer, C.B, Holden, H.M, Thoden, J.B, Smith, R, Rayment, I. | 登録日 | 2000-08-18 | 公開日 | 2000-11-22 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | X-ray structures of the apo and MgATP-bound states of Dictyostelium discoideum myosin motor domain. J.Biol.Chem., 275, 2000
|
|
1G8X
| STRUCTURE OF A GENETICALLY ENGINEERED MOLECULAR MOTOR | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, MYOSIN II HEAVY CHAIN FUSED TO ALPHA-ACTININ 3 | 著者 | Kliche, W, Fujita-Becker, S, Kollmar, M, Manstein, D.J, Kull, F.J. | 登録日 | 2000-11-21 | 公開日 | 2001-01-17 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure of a genetically engineered molecular motor. EMBO J., 20, 2001
|
|
2DFS
| 3-D structure of Myosin-V inhibited state | 分子名称: | Calmodulin, Myosin-5A | 著者 | Liu, J, Taylor, D.W, Krementsova, E.B, Trybus, K.M, Taylor, K.A. | 登録日 | 2006-03-03 | 公開日 | 2006-04-25 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON CRYSTALLOGRAPHY (24 Å) | 主引用文献 | Three-dimensional structure of the myosin V inhibited state by cryoelectron tomography Nature, 442, 2006
|
|
2EC6
| Placopecten Striated Muscle Myosin II | 分子名称: | CALCIUM ION, Myosin essential light chain, Myosin heavy chain, ... | 著者 | Yang, Y, Brown, J, Samudrala, G, Reutzel, R, Szent-Gyorgyi, A. | 登録日 | 2007-02-10 | 公開日 | 2008-02-26 | 最終更新日 | 2021-11-10 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | Rigor-like structures from muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor. Structure, 15, 2007
|
|