8CDQ
Plasmodium falciparum Myosin A full-length, post-rigor state complexed to the inhibitor KNX-002 and Mg.ATP-gamma-S
Summary for 8CDQ
Entry DOI | 10.2210/pdb8cdq/pdb |
Related | 8A12 |
Descriptor | Myosin-A, 1-(4-methoxyphenyl)-~{N}-[(3-thiophen-2-yl-1~{H}-pyrazol-4-yl)methyl]cyclopropan-1-amine, Myosin A tail domain interacting protein, ... (11 entities in total) |
Functional Keywords | malaria, plasmodium falciparum, myosin a, knx-002, antimalarial treatment, molecular motors, motor protein |
Biological source | Plasmodium falciparum (malaria parasite P. falciparum) More |
Total number of polymer chains | 3 |
Total formula weight | 133429.68 |
Authors | Moussaoui, D.,Robblee, J.P.,Robert-Paganin, J.,Auguin, D.,Fisher, F.,Fagnant, P.M.,MacFarlane, J.E.,Schaletzky, J.,Wehri, E.,Mueller-Dieckmann, C.,Baum, J.,Trybus, K.M.,Houdusse, A. (deposition date: 2023-01-31, release date: 2023-06-21, Last modification date: 2023-11-15) |
Primary citation | Moussaoui, D.,Robblee, J.P.,Robert-Paganin, J.,Auguin, D.,Fisher, F.,Fagnant, P.M.,Macfarlane, J.E.,Schaletzky, J.,Wehri, E.,Mueller-Dieckmann, C.,Baum, J.,Trybus, K.M.,Houdusse, A. Mechanism of small molecule inhibition of Plasmodium falciparum myosin A informs antimalarial drug design. Nat Commun, 14:3463-3463, 2023 Cited by PubMed: 37308472DOI: 10.1038/s41467-023-38976-7 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.21 Å) |
Structure validation
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