8A12

Plasmodium falciparum Myosin A full-length, post-rigor state complexed to Mg.ATP-gamma-S

Summary for 8A12

• Entry DOI: 10.2210/pdb8a12/pdb
• Descriptor: Myosin-A, Myosin A tail domain interacting protein, Myosin essential light chain ELC, ... (8 entities in total)
• Functional Keywords: malaria, plasmodium falciparum, myosin a, knx002, antimalarial treatment, molecular motors, motor protein
• Biological source: Plasmodium falciparum (malaria parasite P. falciparum); More
• Total number of polymer chains: 3
• Total formula weight: 132445.61

Authors

Moussaoui, D.,Robblee, J.P.,Auguin, D.,Fisher, F.,Fagnant, P.M.,MacFarlane, J.E.,Mueller-Dieckmann, C.,Baum, J.,Robert-Paganin, J.,Trybus, K.M.,Houdusse, A. (deposition date: 2022-05-31, release date: 2023-06-21, Last modification date: 2024-02-07)

• Primary citation: Moussaoui, D.,Robblee, J.P.,Robert-Paganin, J.,Auguin, D.,Fisher, F.,Fagnant, P.M.,Macfarlane, J.E.,Schaletzky, J.,Wehri, E.,Mueller-Dieckmann, C.,Baum, J.,Trybus, K.M.,Houdusse, A.; Mechanism of small molecule inhibition of Plasmodium falciparum myosin A informs antimalarial drug design.; Nat Commun, 14:3463-3463, 2023; PubMed: 37308472; DOI: 10.1038/s41467-023-38976-7

Experimental method

X-RAY DIFFRACTION (2.03 Å)