PDB: 657 件ウェブページステータス検索Chemie searchBIRD

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3PD8	X-ray structure of the ligand-binding core of GluA2 in complex with (S)-7-HPCA at 2.5 A resolution 分子名称: (7S)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-7-carboxylic acid, ACETIC ACID, CACODYLATE ION, ... 著者 Frydenvang, K, Kastrup, J.S. 登録日 2010-10-22 公開日 2010-12-29 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.476 Å) 主引用文献 Biostructural and pharmacological studies of bicyclic analogues of the 3-isoxazolol glutamate receptor agonist ibotenic acid. J. Med. Chem., 53, 2010
3PD9	X-ray structure of the ligand-binding core of GluA2 in complex with (R)-5-HPCA at 2.1 A resolution 分子名称: (5R)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-5-carboxylic acid, CHLORIDE ION, GLYCEROL, ... 著者 Frydenvang, K, Kastrup, J.S. 登録日 2010-10-22 公開日 2010-12-29 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Biostructural and pharmacological studies of bicyclic analogues of the 3-isoxazolol glutamate receptor agonist ibotenic acid. J. Med. Chem., 53, 2010
3PMW	Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator 分子名称: DIMETHYL SULFOXIDE, GLUTAMIC ACID, GLYCEROL, ... 著者 Maclean, J.K.F, Jamieson, C, Brown, C.I, Campbell, R.A, Gillen, K.J, Gillespie, J, Kazemier, B, Kiczun, M, Lamont, Y, Lyons, A.J, Moir, E.M, Morrow, J.A, Pantling, J, Rankovic, Z, Smith, L. 登録日 2010-11-18 公開日 2011-01-12 最終更新日 2023-05-31 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure based evolution of a novel series of positive modulators of the AMPA receptor. Bioorg.Med.Chem.Lett., 21, 2011
3PMX	Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator 分子名称: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, GLUTAMIC ACID, ... 著者 Maclean, J.K.F, Jamieson, C, Brown, C.I, Campbell, R.A, Gillen, K.J, Gillespie, J, Kazemier, B, Kiczun, M, Lamont, Y, Lyons, A.J, Moir, E.M, Morrow, J.A, Pantling, J, Rankovic, Z, Smith, L. 登録日 2010-11-18 公開日 2011-01-12 最終更新日 2017-08-09 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Structure based evolution of a novel series of positive modulators of the AMPA receptor. Bioorg.Med.Chem.Lett., 21, 2011
3PMV	Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator 分子名称: GLUTAMIC ACID, GLYCEROL, Glutamate receptor 2, ... 著者 Maclean, J.K.F, Jamieson, C, Brown, C.I, Campbell, R.A, Gillen, K.J, Gillespie, J, Kazemier, B, Kiczun, M, Lamont, Y, Lyons, A.J, Moir, E.M, Morrow, J.A, Pantling, J, Rankovic, Z, Smith, L. 登録日 2010-11-18 公開日 2011-01-12 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure based evolution of a novel series of positive modulators of the AMPA receptor. Bioorg.Med.Chem.Lett., 21, 2011
6KSP	Rat GluD1 receptor(splayed conformation) in complex with 7-CKA and Calcium ions 分子名称: Glutamate receptor ionotropic, delta-1 著者 Burada, A.P, Kumar, J. 登録日 2019-08-24 公開日 2020-01-15 最終更新日 2020-01-29 実験手法 ELECTRON MICROSCOPY (8.1 Å) 主引用文献 Cryo-EM structures of the ionotropic glutamate receptor GluD1 reveal a non-swapped architecture. Nat.Struct.Mol.Biol., 27, 2020
6KZM	GluK3 receptor complex with kainate 分子名称: Glutamate receptor ionotropic, kainate 3 著者 Kumar, J, Kumari, J, Burada, A.P. 登録日 2019-09-24 公開日 2020-03-04 実験手法 ELECTRON MICROSCOPY (9.6 Å) 主引用文献 Structural dynamics of the GluK3-kainate receptor neurotransmitter binding domains revealed by cryo-EM. Int.J.Biol.Macromol., 149, 2020
6L6F	GluK3 receptor complex with UBP301 分子名称: Glutamate receptor ionotropic, kainate 3 著者 Kumar, J, Kumari, J, Burada, A.P. 登録日 2019-10-28 公開日 2020-03-04 実験手法 ELECTRON MICROSCOPY (10.6 Å) 主引用文献 Structural dynamics of the GluK3-kainate receptor neurotransmitter binding domains revealed by cryo-EM. Int.J.Biol.Macromol., 149, 2020
6KSS	Rat GluD1 receptor(compact conformation) in complex with 7-CKA and Calcium ions 分子名称: Glutamate receptor ionotropic, delta-1 著者 Burada, A.P, Kumar, J. 登録日 2019-08-26 公開日 2020-01-15 最終更新日 2020-01-29 実験手法 ELECTRON MICROSCOPY (8.1 Å) 主引用文献 Cryo-EM structures of the ionotropic glutamate receptor GluD1 reveal a non-swapped architecture. Nat.Struct.Mol.Biol., 27, 2020
6LU9	Rat ionotropic Glutamate Delta-2 receptor in complex with 7-CKA and Calcium 分子名称: Glutamate receptor ionotropic, delta-2 著者 Kumar, J, Burada, A.P. 登録日 2020-01-27 公開日 2020-06-17 最終更新日 2020-12-30 実験手法 ELECTRON MICROSCOPY (8.8 Å) 主引用文献 The architecture of GluD2 ionotropic delta glutamate receptor elucidated by cryo-EM. J.Struct.Biol., 211, 2020
3QXM	Crystal Structure of Human GluK2 Ligand-Binding Core in Complex with Novel Marine-Derived Toxins, Neodysiherbaine A 分子名称: (2R,3aR,6R,7R,7aR)-2-[(2S)-2-amino-2-carboxyethyl]-6,7-dihydroxyhexahydro-2H-furo[3,2-b]pyran-2-carboxylic acid, Glutamate receptor ionotropic, kainate 2 著者 Unno, M, Sasaki, M, Ikeda-Saito, M. 登録日 2011-03-02 公開日 2011-10-26 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors. J.Mol.Biol., 413, 2011
3RN8	Crystal Structure of iGluR2 Ligand Binding Domain and Symmetrical Carboxyl Containing Potentiator 分子名称: 3,3'-benzene-1,4-diylbis(4-cyano-5-ethylthiophene-2-carboxylic acid), ACETATE ION, GLUTAMIC ACID, ... 著者 Timm, D.E. 登録日 2011-04-22 公開日 2011-05-25 最終更新日 2017-08-23 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation. Mol.Pharmacol., 80, 2011
3R7X	Crystal Structure Analysis of a Quinazolinedione sulfonamide bound to human GluR2: A Novel Class of Competitive AMPA Receptor Antagonists with Oral Activity 分子名称: GLUTAMIC ACID, Glutamate receptor 2, N-[6-(1H-imidazol-1-yl)-7-nitro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl]methanesulfonamide 著者 Kallen, J. 登録日 2011-03-23 公開日 2011-05-18 最終更新日 2017-07-26 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Quinazolinedione sulfonamides: A novel class of competitive AMPA receptor antagonists with oral activity. Bioorg.Med.Chem.Lett., 21, 2011
6MMR	Diheteromeric NMDA receptor GluN1/GluN2A in the '2-Knuckle-Symmetric' conformation, in complex with glycine and glutamate, in the presence of 1 millimolar zinc chloride, 3 millimolar EDTA, and at pH 7.4 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 1, ... 著者 Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. 登録日 2018-10-01 公開日 2018-11-28 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (5.13 Å) 主引用文献 Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor. Cell, 175, 2018
6MMB	Diheteromeric NMDA receptor GluN1/GluN2A in the 'Super-Splayed' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 6.1 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 1, ... 著者 Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. 登録日 2018-09-30 公開日 2018-11-28 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (12.7 Å) 主引用文献 Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor. Cell, 175, 2018
6MMS	Triheteromeric NMDA receptor GluN1/GluN2A/GluN2A* in the '2-Knuckle-Symmetric' conformation, in complex with glycine and glutamate, in the presence of 1 millimolar EDTA, and at pH 7.4 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... 著者 Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. 登録日 2018-10-01 公開日 2018-11-28 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (5.38 Å) 主引用文献 Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor. Cell, 175, 2018
3RTF	Chlorowillardiine bound to the ligand binding domain of GluA2 分子名称: 3-(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine, Glutamate receptor 2, ZINC ION 著者 Ahmed, A.H, Oswald, R.E. 登録日 2011-05-03 公開日 2011-05-18 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Mechanisms of Modal Activation of GluA3 Receptors. Mol.Pharmacol., 80, 2011
3RNN	Crystal Structure of iGluR2 Ligand Binding Domain with Symmetric Sulfonamide Containing Potentiator 分子名称: GLUTAMIC ACID, Glutamate receptor 2, N,N'-(benzene-1,4-diyldiethane-2,1-diyl)dipropane-2-sulfonamide, ... 著者 Timm, D.E. 登録日 2011-04-22 公開日 2011-05-25 最終更新日 2019-07-17 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation. Mol.Pharmacol., 80, 2011
6MMV	Triheteromeric NMDA receptor GluN1/GluN2A/GluN2A* Extracellular Domain in the '2-Knuckle-Asymmetric' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 7.4 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... 著者 Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. 登録日 2018-10-01 公開日 2018-11-28 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (4.71 Å) 主引用文献 Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor. Cell, 175, 2018
6MMG	Diheteromeric NMDA receptor GluN1/GluN2A in the '2-Knuckle-Symmetric' conformation, in complex with glycine and glutamate, in the presence of 1 millimolar EDTA, and at pH 7.4 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... 著者 Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. 登録日 2018-09-30 公開日 2018-11-28 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (6.23 Å) 主引用文献 Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor. Cell, 175, 2018
6MMX	Triheteromeric NMDA receptor GluN1/GluN2A/GluN2A* in the 'Extended' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 7.4 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... 著者 Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. 登録日 2018-10-01 公開日 2018-11-28 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (6.99 Å) 主引用文献 Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor. Cell, 175, 2018
6MMN	Diheteromeric NMDA receptor GluN1/GluN2A in the '2-Knuckle-Symmetric' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 8.0 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... 著者 Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. 登録日 2018-10-01 公開日 2018-11-28 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (7.51 Å) 主引用文献 Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor. Cell, 175, 2018
6MMJ	Diheteromeric NMDA receptor GluN1/GluN2A in the 'Super-Splayed' conformation, in complex with glycine and glutamate, in the presence of 1 millimolar zinc chloride, and at pH 7.4 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 1, ... 著者 Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. 登録日 2018-09-30 公開日 2018-11-28 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (16.5 Å) 主引用文献 Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor. Cell, 175, 2018
6MMH	Diheteromeric NMDA receptor GluN1/GluN2A in the 'Extended-2' conformation, in complex with glycine and glutamate, in the presence of 1 millimolar zinc chloride, and at pH 7.4 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 1, ... 著者 Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. 登録日 2018-09-30 公開日 2018-11-28 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (8.21 Å) 主引用文献 Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor. Cell, 175, 2018
6MMW	Triheteromeric NMDA receptor GluN1/GluN2A/GluN2A* in the '2-Knuckle-Symmetric' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 7.4 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... 著者 Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. 登録日 2018-10-01 公開日 2018-11-28 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (6.2 Å) 主引用文献 Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor. Cell, 175, 2018

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