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2HIU	NMR STRUCTURE OF HUMAN INSULIN IN 20% ACETIC ACID, ZINC-FREE, 10 STRUCTURES Descriptor: INSULIN Authors: Hua, Q.X, Gozani, S.N, Chance, R.E, Hoffmann, J.A, Frank, B.H, Weiss, M.A. Deposit date: 1996-10-08 Release date: 1997-04-01 Last modified: 2017-11-29 Method: SOLUTION NMR Cite: Structure of a protein in a kinetic trap. Nat.Struct.Biol., 2, 1995
5T7R	A6-A11 trans-dicarba human insulin Descriptor: Insulin A chain, Insulin B chain Authors: Menting, J.G, Lawrence, M.C, Robinson, A.J, Forbes, B.E. Deposit date: 2016-09-05 Release date: 2017-12-06 Last modified: 2019-06-19 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Insulin in motion: The A6-A11 disulfide bond allosterically modulates structural transitions required for insulin activity. Sci Rep, 7, 2017
5UDP	High resolution x-ray crystal structure of synthetic insulin lispro Descriptor: CHLORIDE ION, Insulin Lispro A chain, Insulin Lispro B chain, ... Authors: Mandal, K, Dhayalan, B, Kent, S.B.H. Deposit date: 2016-12-28 Release date: 2017-01-11 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.348 Å) Cite: Scope and Limitations of Fmoc Chemistry SPPS-Based Approaches to the Total Synthesis of Insulin Lispro via Ester Insulin. Chemistry, 23, 2017
5USP	Insulin with proline analog Pip at position B28 in the T2 state Descriptor: Insulin Chain A, Insulin Chain B, SODIUM ION Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-13 Release date: 2018-02-21 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.174 Å) Cite: Insulin with proline analog Pip at position B28 in the T2 state To Be Published
5UU4	Insulin with proline analog ThioP at position B28 in the R6 state Descriptor: CHLORIDE ION, Insulin A Chain, Insulin B Chain, ... Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-16 Release date: 2018-02-21 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.973 Å) Cite: Insulin with proline analog ThioP at position B28 in the R6 state To Be Published
5USS	Insulin with proline analog PiP at position B28 in the R6 state Descriptor: CHLORIDE ION, Insulin Chain A, Insulin Chain B, ... Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-13 Release date: 2018-02-21 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.061 Å) Cite: Insulin with proline analog PiP at position B28 in the R6 state To Be Published
5UU2	Insulin with proline analog ThioP at position B28 in the T2 state Descriptor: Insulin Chain A, Insulin Chain B Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-15 Release date: 2018-02-21 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.223 Å) Cite: Insulin with proline analog ThioP at position B28 in the T2 state To Be Published
5USV	Insulin with proline analog AzeP at position B28 in the T2 state Descriptor: Insulin Chain A, Insulin Chain B, SODIUM ION Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-14 Release date: 2018-02-21 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Insulin with proline analog AzeP at position B28 in the T2 state To Be Published
5UOZ	Insulin with proline analog FyP at position B28 in the T2 state Descriptor: Insulin Chain A, Insulin Chain B Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-01 Release date: 2018-02-07 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.17463875 Å) Cite: Insulin with proline analog FyP at position B28 in the T2 state To Be Published
5URU	Insulin with proline analog DhP at position B28 in the R6 state Descriptor: CHLORIDE ION, Insulin Chain A, Insulin Chain B, ... Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-13 Release date: 2018-02-21 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.41 Å) Cite: Insulin with proline analog DhP at position B28 in the R6 state To Be Published
5UQA	Insulin with proline analog FzP at position B28 in the R6 state Descriptor: ACETONE, CHLORIDE ION, GLYCEROL, ... Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-07 Release date: 2018-02-21 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.31000245 Å) Cite: Insulin with proline analog FzP at position B28 in the R6 state To Be Published
5UU3	Insulin with proline analog DfP at position B28 in the R6 state Descriptor: CHLORIDE ION, Insulin, chain A, ... Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-16 Release date: 2018-02-21 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Insulin with proline analog DfP at position B28 in the R6 state To Be Published
5URT	Insulin with proline analog DhP at position B28 in the T2 state Descriptor: Insulin Chain A, Insulin Chain B, SODIUM ION Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-12 Release date: 2018-02-14 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.18 Å) Cite: Insulin with proline analog DhP at position B28 in the T2 state To Be Published
5VIZ	X-Ray structure of Insulin Glargine Descriptor: Insulin, chain alpha, chain beta Authors: Reyes-Grajeda, J.P, Romero, A. Deposit date: 2017-04-17 Release date: 2017-10-18 Method: X-RAY DIFFRACTION (1.7 Å) Cite: X-Ray structure of Insulin Glargine To Be Published
5WDM	An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein Descriptor: Single-chain insulin analog Authors: Yee, V.C, Aldabbagh, K, Peng, Y. Deposit date: 2017-07-05 Release date: 2017-11-15 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.803 Å) Cite: An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein. J. Biol. Chem., 293, 2018
7RKD	X-Ray structure of Insulin Analog GLULISINE Descriptor: Insulin B chain analog, Insulin chain A, ZINC ION Authors: Reyes-Grajeda, J.P. Deposit date: 2021-07-22 Release date: 2022-07-27 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.25 Å) Cite: Insulin ANALOGS To Be Published
7S4Y	Serial Macromolecular Crystallography at ALBA Synchrotron Light Source - Insulin Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ... Authors: Martin-Garcia, J.M, Botha, S, Hu, H, Jernigan, R, Castellvi, A, Lisova, S, Gil, F, Calisto, B, Crespo, I, Roy-Chowdbury, S, Grieco, A, Ketawala, G, Weierstall, U, Spence, J, Fromme, P, Zatsepin, N, Boer, R, Carpena, X. Deposit date: 2021-09-09 Release date: 2021-10-27 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.71 Å) Cite: Serial macromolecular crystallography at ALBA Synchrotron Light Source. J.Synchrotron Radiat., 29, 2022
3TT8	Crystal Structure Analysis of Cu Human Insulin Derivative Descriptor: COPPER (II) ION, INSULIN A-CHAIN, INSULIN B-CHAIN Authors: Prugovecki, B, Matkovic-Calogovic, D. Deposit date: 2011-09-14 Release date: 2011-10-19 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.12 Å) Cite: Crystal Structure Analysis of Cu Human Insulin Derivative To be Published
3U4N	A novel covalently linked insulin dimer Descriptor: Insulin A chain, Insulin B chain Authors: Norrman, M, Vinther, T.N. Deposit date: 2011-10-10 Release date: 2012-04-11 Method: X-RAY DIFFRACTION (1.98 Å) Cite: Novel covalently linked insulin dimer engineered to investigate the function of insulin dimerization. Plos One, 7, 2012
1PMX	INSULIN-LIKE GROWTH FACTOR-I BOUND TO A PHAGE-DERIVED PEPTIDE Descriptor: IGF-1 ANTAGONIST F1-1, Insulin-like growth factor IB Authors: Skelton, N.J. Deposit date: 2003-06-11 Release date: 2003-10-21 Last modified: 2022-02-23 Method: SOLUTION NMR Cite: Complex with a Phage Display-Derived Peptide Provides Insight into the Function of Insulin-like Growth Factor I Biochemistry, 42, 2003
1Q4V	CRYSTAL STRUCTURE OF ALLO-ILEA2-INSULIN, AN INACTIVE CHIRAL ANALOGUE: IMPLICATIONS FOR THE MECHANISM OF RECEPTOR Descriptor: Insulin, PHENOL, ZINC ION Authors: Wan, Z.L, Xu, B, Chu, Y.C, Katsoyannis, P.G, Weiss, M.A. Deposit date: 2003-08-04 Release date: 2003-08-19 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of allo-Ile(A2)-insulin, an inactive chiral analogue: implications for the mechanism of receptor binding. Biochemistry, 42, 2003
3V19	Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health Descriptor: CHLORIDE ION, Insulin, PHENOL, ... Authors: Wan, Z.L, Hua, Q.X, Wickramasinghe, N.P, Huang, K, Petkova, A.T, Hu, S.Q, Phillips, N.B, Yeh, I.J, Whittake, J, Ismail-Beigi, F, Katsoyyannis, P.G, Tycko, R, Weiss, M.A. Deposit date: 2011-12-09 Release date: 2012-12-12 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health To be Published
1QIZ	HUMAN INSULIN HEXAMERS WITH CHAIN B HIS MUTATED TO TYR COMPLEXED WITH RESORCINOL Descriptor: CHLORIDE ION, INSULIN A CHAIN, INSULIN B CHAIN, ... Authors: Tang, L, Whittingham, J.L, Verma, C.S, Caves, L.S.D, Dodson, G.G. Deposit date: 1999-06-18 Release date: 1999-06-22 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural Consequences of the B5 Histidine --> Tyrosine Mutation in Human Insulin Characterized by X-Ray Crystallography and Conformational Analysis. Biochemistry, 38, 1999
3V1G	Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health Descriptor: CHLORIDE ION, Insulin, PHENOL, ... Authors: Wan, Z.L, Hua, Q.X, Wickramasinghe, N.P, Huang, K, Petkova, A.T, Hu, S.Q, Phillips, N.B, Yeh, I.J, Whittake, J, Ismail-Beigi, F, Katsoyyannis, P.G, Tycko, R, Weiss, M.A. Deposit date: 2011-12-09 Release date: 2012-12-12 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health To be Published
1QJ0	HUMAN INSULIN HEXAMERS WITH CHAIN B HIS MUTATED TO TYR Descriptor: CHLORIDE ION, INSULIN A CHAIN, INSULIN B CHAIN, ... Authors: Tang, L, Whittingham, J.L, Verma, C.S, Caves, L.S.D, Dodson, G.G. Deposit date: 1999-06-18 Release date: 1999-06-22 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural Consequences of the B5 Histidine --> Tyrosine Mutation in Human Insulin Characterized by X-Ray Crystallography and Conformational Analysis. Biochemistry, 38, 1999

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