1TYM
 
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1UZ9
 | | Crystallographic and solution studies of N-lithocholyl insulin: a new generation of prolonged-acting insulins. | | Descriptor: | (2S)-2-AMINO-6-({(4R)-4-[(10R,13S)-10,13-DIMETHYL-3-OXOHEXADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-17-YL]PENTANOYL}AMINO)HEXANOIC ACID, CHLORIDE ION, INSULIN, ... | | Authors: | Whittingham, J.L, Jonassen, I, Havelund, S, Roberts, S.M, Dodson, E.J, Verma, C.S, Wilkinson, A.J, Dodson, G.G. | | Deposit date: | 2004-03-08 | | Release date: | 2005-03-03 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Crystallographic and Solution Studies of N-Lithocholyl Insulin: A New Generation of Prolonged-Acting Human Insulins
Biochemistry, 43, 2004
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2OM0
 | | Structure of human insulin in presence of urea at pH 6.5 | | Descriptor: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | | Authors: | Norrman, M, Schluckebier, G. | | Deposit date: | 2007-01-20 | | Release date: | 2007-12-04 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Crystallographic characterization of two novel crystal forms of human insulin induced by chaotropic agents and a shift in pH.
Bmc Struct.Biol., 7, 2007
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2OLY
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2OM1
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2OMH
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2OMI
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2R35
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2QIU
 | | Structure of Human Arg-Insulin | | Descriptor: | Insulin, ZINC ION | | Authors: | Sreekanth, R, Pattabhi, V, Rajan, S.S. | | Deposit date: | 2007-07-05 | | Release date: | 2008-02-26 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural interpretation of reduced insulin activity as seen in the crystal structure of human Arg-insulin
Biochimie, 90, 2008
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2R34
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2R36
 | | Crystal structure of ni human ARG-insulin | | Descriptor: | CHLORIDE ION, Insulin, NICKEL (II) ION, ... | | Authors: | Sreekanth, R, Pattabhi, V, Rajan, S.S. | | Deposit date: | 2007-08-29 | | Release date: | 2008-09-02 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Metal induced structural changes observed in hexameric insulin
Int.J.Biol.Macromol., 44, 2009
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2RN5
 | | Humal Insulin Mutant B31Lys-B32Arg | | Descriptor: | Insulin | | Authors: | Bocian, W, Kozerski, L. | | Deposit date: | 2007-12-06 | | Release date: | 2008-10-28 | | Last modified: | 2022-03-16 | | Method: | SOLUTION NMR | | Cite: | NMR structure of biosynthetic engineered human insulin monomer B31(Lys)-B32(Arg) in water/acetonitrile solution. Comparison with the solution structure of native human insulin monomer
Biopolymers, 89, 2008
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2TCI
 | | X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL | | Descriptor: | THIOCYANATE INSULIN, THIOCYANATE ION, ZINC ION | | Authors: | Whittingham, J.L, Dodson, E.J, Moody, P.C.E, Dodson, G.G. | | Deposit date: | 1995-09-13 | | Release date: | 1996-01-29 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | X-ray crystallographic studies on hexameric insulins in the presence of helix-stabilizing agents, thiocyanate, methylparaben, and phenol.
Biochemistry, 34, 1995
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2VJZ
 | | Crystal structure form ultalente insulin microcrystals | | Descriptor: | CHLORIDE ION, INSULIN A CHAIN, INSULIN B CHAIN, ... | | Authors: | Wagner, A, Diez, J, Schulze-Briese, C, Schluckebier, G. | | Deposit date: | 2007-12-14 | | Release date: | 2008-09-16 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal Structure of Ultralente-A Microcrystalline Insulin Suspension.
Proteins, 74, 2009
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2VK0
 | | Crystal structure form ultalente insulin microcrystals | | Descriptor: | 4-HYDROXY-BENZOIC ACID METHYL ESTER, INSULIN A CHAIN, INSULIN B CHAIN, ... | | Authors: | Wagner, A, Diez, J, Schulze-Briese, C, Schluckebier, G. | | Deposit date: | 2007-12-14 | | Release date: | 2008-09-16 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal Structure of Ultralente--A Microcrystalline Insulin Suspension.
Proteins, 74, 2009
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2W44
 | | Structure DeltaA1-A4 insulin | | Descriptor: | CHLORIDE ION, INSULIN, RESORCINOL, ... | | Authors: | Thorsoee, K.S, Schlein, M, Brandt, J, Schluckebier, G, Naver, H. | | Deposit date: | 2008-11-21 | | Release date: | 2009-12-22 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Kinetic Evidence for the Sequential Association of Insulin Binding Sites 1 and 2 to the Insulin Receptor and the Influence of Receptor Isoform.
Biochemistry, 49, 2010
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2WS0
 | | Semi-synthetic analogue of human insulin NMeAlaB26-insulin at pH 7.5 | | Descriptor: | INSULIN A CHAIN, INSULIN B CHAIN | | Authors: | Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G. | | Deposit date: | 2009-09-03 | | Release date: | 2010-02-09 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues.
Proc.Natl.Acad.Sci.USA, 107, 2010
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2WS6
 | | Semi-synthetic analogue of human insulin NMeTyrB26-insulin in hexamer form | | Descriptor: | CHLORIDE ION, GLYCEROL, INSULIN A CHAIN, ... | | Authors: | Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G. | | Deposit date: | 2009-09-03 | | Release date: | 2010-02-09 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues.
Proc.Natl.Acad.Sci.USA, 107, 2010
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2WRX
 | | Semi-synthetic analogue of human insulin NMeAlaB26-insulin at pH 3.0 | | Descriptor: | INSULIN A CHAIN, INSULIN B CHAIN, SODIUM ION | | Authors: | Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G. | | Deposit date: | 2009-09-02 | | Release date: | 2010-02-09 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues.
Proc.Natl.Acad.Sci.USA, 107, 2010
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1AI0
 | | R6 HUMAN INSULIN HEXAMER (NON-SYMMETRIC), NMR, 10 STRUCTURES | | Descriptor: | PHENOL, R6 INSULIN HEXAMER, ZINC ION | | Authors: | Chang, X, Jorgensen, A.M.M, Bardrum, P, Led, J.J. | | Deposit date: | 1997-04-30 | | Release date: | 1997-11-12 | | Last modified: | 2022-02-16 | | Method: | SOLUTION NMR | | Cite: | Solution structures of the R6 human insulin hexamer.
Biochemistry, 36, 1997
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1AIY
 | | R6 HUMAN INSULIN HEXAMER (SYMMETRIC), NMR, 10 STRUCTURES | | Descriptor: | PHENOL, R6 INSULIN HEXAMER, ZINC ION | | Authors: | Chang, X, Jorgensen, A.M.M, Bardrum, P, Led, J.J. | | Deposit date: | 1997-04-30 | | Release date: | 1997-11-12 | | Last modified: | 2022-02-16 | | Method: | SOLUTION NMR | | Cite: | Solution structures of the R6 human insulin hexamer.
Biochemistry, 36, 1997
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1A7F
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1B9G
 | | INSULIN-LIKE-GROWTH-FACTOR-1 | | Descriptor: | PROTEIN (GROWTH FACTOR IGF-1) | | Authors: | De Wolf, E, Gill, R, Geddes, S, Pitts, J, Wollmer, A, Grotzinger, J. | | Deposit date: | 1999-02-11 | | Release date: | 1999-02-23 | | Last modified: | 2023-12-27 | | Method: | SOLUTION NMR | | Cite: | Solution structure of a mini IGF-1.
Protein Sci., 5, 1996
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1B2D
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1B2C
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