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8BXR	Titin FnIII-domain I109-I111 (I/A4-A/A6) from the MIR region Descriptor: 1,2-ETHANEDIOL, Titin Authors: Mayans, O, Fleming, J.R, Williams, R. Deposit date: 2022-12-09 Release date: 2023-02-15 Last modified: 2023-03-08 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Immunological and Structural Characterization of Titin Main Immunogenic Region; I110 Domain Is the Target of Titin Antibodies in Myasthenia Gravis. Biomedicines, 11, 2023
8K53	Structure of the Dimeric Human CNTN2 Ig 1-6-FNIII 1-2 Domain in an Asymmetric State Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Contactin-2, ... Authors: Zhang, Z.Z. Deposit date: 2023-07-21 Release date: 2023-12-06 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Structure of human CNTN2 immunoglobulin domains 1-6 homo-dimer To Be Published
8PB1	Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 1), obtained after local refinement. Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, Interleukin-12 receptor subunit beta-2,Calmodulin-1, ... Authors: Felix, J, Bloch, Y, Savvides, S.N. Deposit date: 2023-06-08 Release date: 2024-02-07 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23. Nat.Struct.Mol.Biol., 31, 2024
8OE0	Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 2). Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, ... Authors: Felix, J, Bloch, Y, Savvides, S.N. Deposit date: 2023-03-10 Release date: 2024-02-07 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (4.6 Å) Cite: Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23. Nat.Struct.Mol.Biol., 31, 2024
8OE4	Cryo-EM structure of a pre-dimerized human IL-23 complete extracellular signaling complex. Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, ... Authors: Bloch, Y, Felix, J, Savvides, S.N. Deposit date: 2023-03-10 Release date: 2024-02-07 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23. Nat.Struct.Mol.Biol., 31, 2024
8ODZ	Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 1). Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, Interleukin-12 receptor subunit beta-2,Calmodulin-1, ... Authors: Felix, J, Bloch, Y, Savvides, S.N. Deposit date: 2023-03-10 Release date: 2024-02-07 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23. Nat.Struct.Mol.Biol., 31, 2024
8Q6T	Helical reconstruction of the relaxed thick filament from FIB milled left ventricular mouse myofibrils Descriptor: Myosin binding protein C, cardiac, Myosin light chain 3, ... Authors: Tamborrini, D, Raunser, S. Deposit date: 2023-08-14 Release date: 2023-11-01 Last modified: 2023-12-06 Method: ELECTRON MICROSCOPY (18 Å) Cite: Structure of the native myosin filament in the relaxed cardiac sarcomere. Nature, 623, 2023
8QY4	Structure of interleukin 11 (gp130 P496L mutant). Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-11, ... Authors: Gardner, S, Bubeck, D, Jin, Y. Deposit date: 2023-10-25 Release date: 2024-02-21 Method: ELECTRON MICROSCOPY (3.06 Å) Cite: Structure of interleukin 11 (gp130 P496L mutant). To Be Published
8QY5	Structure of interleukin 6. Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-6, ... Authors: Gardner, S, Bubeck, D, Jin, Y. Deposit date: 2023-10-25 Release date: 2024-02-21 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structure of interleukin 6. To Be Published
8QY6	Structure of interleukin 6 (gp130 P496L mutant). Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-6, ... Authors: Gardner, S, Bubeck, D, Jin, Y. Deposit date: 2023-10-25 Release date: 2024-02-21 Method: ELECTRON MICROSCOPY (3.16 Å) Cite: Structure of interleukin 6 (gp130 P496L mutant). To Be Published
1ZLG	Solution structure of the extracellular matrix protein anosmin-1 Descriptor: Anosmin 1 Authors: Hu, Y, Sun, Z, Eaton, J.T, Bouloux, P.M, Perkins, S.J. Deposit date: 2005-05-06 Release date: 2006-05-09 Last modified: 2024-05-22 Method: SOLUTION SCATTERING Cite: Extended and Flexible Domain Solution Structure of the Extracellular Matrix Protein Anosmin-1 by X-ray Scattering, Analytical Ultracentrifugation and Constrained Modelling. J.Mol.Biol., 350, 2005
2AEW	A model for growth hormone receptor activation based on subunit rotation within a receptor dimer Descriptor: Growth hormone receptor Authors: Adams, J.J, McKinstry, W.J, Parker, M.W, Waters, M.J. Deposit date: 2005-07-24 Release date: 2005-11-01 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Model for growth hormone receptor activation based on subunit rotation within a receptor dimer. Nat.Struct.Mol.Biol., 12, 2005
2IBG	Crystal Structure of Hedgehog Bound to the FNIII Domains of Ihog Descriptor: CG9211-PA, PHOSPHATE ION, Protein hedgehog Authors: McLellan, J.S, Leahy, D.J. Deposit date: 2006-09-11 Release date: 2006-10-24 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structure of a heparin-dependent complex of Hedgehog and Ihog. Proc.Natl.Acad.Sci.Usa, 103, 2006
6Z3M	Repulsive Guidance Molecule B (RGMB) in complex with Growth Differentiation Factor 5 (GDF5) and Neogenin 1 (NEO1). Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Growth/differentiation factor 5, Neogenin, ... Authors: Malinauskas, T, Peer, T.V, Bishop, B, Muller, T.D, Siebold, C. Deposit date: 2020-05-21 Release date: 2020-07-01 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (5.501 Å) Cite: Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex. Proc.Natl.Acad.Sci.USA, 117, 2020
4UI2	Crystal structure of the ternary RGMB-BMP2-NEO1 complex Descriptor: ACETATE ION, BONE MORPHOGENETIC PROTEIN 2, BMP2, ... Authors: Healey, E.G, Bishop, B, Elegheert, J, Bell, C.H, Padilla-Parra, S, Siebold, C. Deposit date: 2015-03-27 Release date: 2015-05-06 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (3.15 Å) Cite: Repulsive Guidance Molecule is a Structural Bridge between Neogenin and Bone Morphogenetic Protein. Nat.Struct.Mol.Biol., 22, 2015
5DC4	CRYSTAL STRUCTURE OF MONOBODY AS25/ABL1 SH2 DOMAIN COMPLEX, CRYSTAL A Descriptor: AS25 monobody, GLYCEROL, Tyrosine-protein kinase ABL1 Authors: Wojcik, J.B, Koide, A, Koide, S. Deposit date: 2015-08-23 Release date: 2016-03-02 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.48 Å) Cite: Allosteric Inhibition of Bcr-Abl Kinase by High Affinity Monobody Inhibitors Directed to the Src Homology 2 (SH2)-Kinase Interface. J.Biol.Chem., 291, 2016
5DC0	CRYSTAL STRUCTURE OF MONOBODY GG3/ABL1 SH2 DOMAIN COMPLEX Descriptor: Fibronectin, Tyrosine-protein kinase ABL1 Authors: Wojcik, J.B, Grabe, G, Koide, S. Deposit date: 2015-08-22 Release date: 2016-03-02 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.23 Å) Cite: Allosteric Inhibition of Bcr-Abl Kinase by High Affinity Monobody Inhibitors Directed to the Src Homology 2 (SH2)-Kinase Interface. J.Biol.Chem., 291, 2016
5DC9	CRYSTAL STRUCTURE OF MONOBODY AS25/ABL1 SH2 DOMAIN COMPLEX, CRYSTAL B Descriptor: AS25 monobody, GLYCEROL, IMIDAZOLE, ... Authors: Wojcik, J.B, Koide, A, Koide, S. Deposit date: 2015-08-23 Release date: 2016-03-02 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.56 Å) Cite: Allosteric Inhibition of Bcr-Abl Kinase by High Affinity Monobody Inhibitors Directed to the Src Homology 2 (SH2)-Kinase Interface. J.Biol.Chem., 291, 2016
4JEG	Crystal Structure of Monobody CS1/SHP2 C-SH2 Domain Complex Descriptor: Monobody CS1, Tyrosine-protein phosphatase non-receptor type 11 Authors: Sha, F, Koide, S. Deposit date: 2013-02-26 Release date: 2013-08-28 Last modified: 2014-03-12 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Dissection of the BCR-ABL signaling network using highly specific monobody inhibitors to the SHP2 SH2 domains. Proc.Natl.Acad.Sci.USA, 110, 2013
4JE4	Crystal Structure of Monobody NSa1/SHP2 N-SH2 Domain Complex Descriptor: Monobody NSa1, Tyrosine-protein phosphatase non-receptor type 11 Authors: Sha, F, Koide, S. Deposit date: 2013-02-26 Release date: 2013-08-28 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.31 Å) Cite: Dissection of the BCR-ABL signaling network using highly specific monobody inhibitors to the SHP2 SH2 domains. Proc.Natl.Acad.Sci.USA, 110, 2013

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