5U6O
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5U6P
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7YIJ
| Human KCNH5 pore dilation but the non-conducting state | Descriptor: | POTASSIUM ION, Potassium voltage-gated channel subfamily H member 5 | Authors: | Zhang, M.F. | Deposit date: | 2022-07-16 | Release date: | 2023-04-05 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel. Nat Commun, 14, 2023
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7YID
| Human KCNH5 closed state 1 | Descriptor: | POTASSIUM ION, Potassium voltage-gated channel subfamily H member 5 | Authors: | Zhang, M.F. | Deposit date: | 2022-07-16 | Release date: | 2023-04-05 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel. Nat Commun, 14, 2023
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7YIE
| Human KCNH5-closed state 2 | Descriptor: | POTASSIUM ION, Potassium voltage-gated channel subfamily H member 5 | Authors: | Zhang, M.F. | Deposit date: | 2022-07-16 | Release date: | 2023-04-05 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel. Nat Commun, 14, 2023
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7YIH
| Human KCNH5 open state | Descriptor: | POTASSIUM ION, Potassium voltage-gated channel subfamily H member 5 | Authors: | Zhang, M.F. | Deposit date: | 2022-07-16 | Release date: | 2023-04-05 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel. Nat Commun, 14, 2023
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7YIF
| Human KCNH5 pre-open state 1 | Descriptor: | POTASSIUM ION, Potassium voltage-gated channel subfamily H member 5 | Authors: | Zhang, M.F. | Deposit date: | 2022-07-16 | Release date: | 2023-04-05 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel. Nat Commun, 14, 2023
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7YIG
| Human KCNH5 pre-open state 2 | Descriptor: | POTASSIUM ION, Potassium voltage-gated channel subfamily H member 5 | Authors: | Zhang, M.F. | Deposit date: | 2022-07-16 | Release date: | 2023-04-05 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel. Nat Commun, 14, 2023
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5VA3
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5VA2
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8H3V
| Cryo-EM structure of the full transcription activation complex NtcA-NtcB-TAC | Descriptor: | DNA (125-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Han, S.J, Jiang, Y.L, You, L.L, Shen, L.Q, Wu, X.X, Yang, F, Kong, W.W, Chen, Z.P, Zhang, Y, Zhou, C.Z. | Deposit date: | 2022-10-09 | Release date: | 2023-10-04 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | DNA looping mediates cooperative transcription activation. Nat.Struct.Mol.Biol., 31, 2024
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8H40
| Cryo-EM structure of the transcription activation complex NtcA-TAC | Descriptor: | DNA (125-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Han, S.J, Jiang, Y.L, You, L.L, Shen, L.Q, Wu, X.X, Yang, F, Kong, W.W, Chen, Z.P, Zhang, Y, Zhou, C.Z. | Deposit date: | 2022-10-09 | Release date: | 2023-10-04 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | DNA looping mediates cooperative transcription activation. Nat.Struct.Mol.Biol., 31, 2024
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5V4S
| CryoEM Structure of a Prokaryotic Cyclic Nucleotide-Gated Ion Channel | Descriptor: | Transporter, cation channel family / cyclic nucleotide-binding domain multi-domain protein | Authors: | James, Z.M, Borst, A.J, Haitin, Y, Frenz, B, DiMaio, F, Zagotta, W.N, Veesler, D. | Deposit date: | 2017-03-10 | Release date: | 2017-04-12 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | CryoEM structure of a prokaryotic cyclic nucleotide-gated ion channel. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5VA1
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2OZ6
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5W5A
| Crystal structure of Mycobacterium tuberculosis CRP-FNR family transcription factor Cmr (Rv1675c) | Descriptor: | CHLORIDE ION, HTH-type transcriptional regulator Cmr, SULFATE ION | Authors: | Cheung, J, Cassidy, M, Ginter, C, Ranganathan, S, Pata, D.J, McDonough, K.A. | Deposit date: | 2017-06-14 | Release date: | 2017-12-13 | Last modified: | 2019-01-09 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Novel structural features drive DNA binding properties of Cmr, a CRP family protein in TB complex mycobacteria. Nucleic Acids Res., 46, 2018
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5W5B
| Crystal structure of Mycobacterium tuberculosis CRP-FNR family transcription factor Cmr (Rv1675c), truncated construct | Descriptor: | CHLORIDE ION, HTH-type transcriptional regulator Cmr | Authors: | Cheung, J, Cassidy, M, Ginter, C, Ranganathan, S, Pata, D.J, McDonough, K.A. | Deposit date: | 2017-06-14 | Release date: | 2017-12-13 | Last modified: | 2018-01-24 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Novel structural features drive DNA binding properties of Cmr, a CRP family protein in TB complex mycobacteria. Nucleic Acids Res., 46, 2018
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2QCS
| A complex structure between the Catalytic and Regulatory subunit of Protein Kinase A that represents the inhibited state | Descriptor: | ACETATE ION, GLYCEROL, MANGANESE (II) ION, ... | Authors: | Kim, C, Cheng, C.Y, Saldanha, A.S, Taylor, S.S. | Deposit date: | 2007-06-19 | Release date: | 2007-11-06 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation. Cell(Cambridge,Mass.), 130, 2007
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2QVS
| Crystal Structure of Type IIa Holoenzyme of cAMP-dependent Protein Kinase | Descriptor: | cAMP-dependent protein kinase type II-alpha regulatory subunit, cAMP-dependent protein kinase, alpha-catalytic subunit | Authors: | Wu, J, Brown, S.H.J, von Daake, S, Taylor, S.S. | Deposit date: | 2007-08-08 | Release date: | 2007-10-23 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | PKA type IIalpha holoenzyme reveals a combinatorial strategy for isoform diversity. Science, 318, 2007
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5JR7
| Crystal structure of an ACRDYS heterodimer [RIa(92-365):C] of PKA | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase type I-alpha regulatory subunit | Authors: | Bruystens, J.G.H, Wu, J, Taylor, S.S. | Deposit date: | 2016-05-05 | Release date: | 2017-03-15 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.56 Å) | Cite: | Structure of a PKA RI alpha Recurrent Acrodysostosis Mutant Explains Defective cAMP-Dependent Activation. J. Mol. Biol., 428, 2016
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7T8O
| Crystal Structure of the Crp/Fnr Family Transcriptional Regulator from Listeria monocytogenes | Descriptor: | Lmo0753 protein, SULFATE ION | Authors: | Kim, Y, Makowska-Grzyska, M, Maltseva, N, Shatsman, S, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2021-12-16 | Release date: | 2021-12-29 | Last modified: | 2023-04-19 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | Crystal Structure of the Crp/Fnr Family Transcriptional Regulator from Listeria monocytogenes To Be Published
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6V1X
| Cryo-EM Structure of the Hyperpolarization-Activated Potassium Channel KAT1: Tetramer | Descriptor: | (2S)-1-(nonanoyloxy)-3-(phosphonooxy)propan-2-yl tetradecanoate, (3beta,5beta,14beta,17alpha)-cholestan-3-ol, Potassium channel KAT1 | Authors: | Clark, M.D, Contreras, G.F, Shen, R, Perozo, E. | Deposit date: | 2019-11-21 | Release date: | 2020-06-03 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Electromechanical coupling in the hyperpolarization-activated K + channel KAT1. Nature, 583, 2020
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6UQF
| Human HCN1 channel in a hyperpolarized conformation | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, MERCURY (II) ION, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | Authors: | Lee, C.-H, MacKinnon, R. | Deposit date: | 2019-10-19 | Release date: | 2019-12-11 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.04 Å) | Cite: | Voltage Sensor Movements during Hyperpolarization in the HCN Channel. Cell, 179, 2019
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6UQG
| Human HCN1 channel Y289D mutant | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | Authors: | Lee, C.-H, MacKinnon, R. | Deposit date: | 2019-10-19 | Release date: | 2019-12-11 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.54 Å) | Cite: | Voltage Sensor Movements during Hyperpolarization in the HCN Channel. Cell, 179, 2019
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7TJ6
| SthK open state, cAMP-bound in the presence of POPA | Descriptor: | (2R)-1-(hexadecanoyloxy)-3-(phosphonooxy)propan-2-yl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Putative transcriptional regulator, ... | Authors: | Schmidpeter, P.A, Nimigean, C.M. | Deposit date: | 2022-01-14 | Release date: | 2022-10-26 | Last modified: | 2022-11-30 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Anionic lipids unlock the gates of select ion channels in the pacemaker family. Nat.Struct.Mol.Biol., 29, 2022
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