7RAS
 
 | |
7L2O
 | |
7L2V
 | | cryo-EM structure of RTX-bound minimal TRPV1 with NMDG at state b | | 分子名称: | 6-deoxy-6-(methylamino)-D-galactitol, SODIUM ION, Transient receptor potential cation channel subfamily V member 1, ... | | 著者 | Zhang, K, Julius, D, Cheng, Y. | | 登録日 | 2020-12-17 | | 公開日 | 2021-09-22 | | 最終更新日 | 2021-10-13 | | 実験手法 | ELECTRON MICROSCOPY (3.64 Å) | | 主引用文献 | Structural snapshots of TRPV1 reveal mechanism of polymodal functionality.
Cell, 184, 2021
|
|
7XJ2
 | | Structure of human TRPV3_G573S in complex with Trpvicin in C4 symmetry | | 分子名称: | Fusion protein of Transient receptor potential cation channel subfamily V member 3 and 3C-GFP, N-[5-[2-(2-cyanopropan-2-yl)pyridin-4-yl]-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxy-pyrimidine-5-carboxamide | | 著者 | Fan, J, Yue, Z, Jiang, D, Lei, X. | | 登録日 | 2022-04-14 | | 公開日 | 2022-11-09 | | 最終更新日 | 2023-01-11 | | 実験手法 | ELECTRON MICROSCOPY (3.64 Å) | | 主引用文献 | Structural basis of TRPV3 inhibition by an antagonist.
Nat.Chem.Biol., 19, 2023
|
|
7L2J
 | | Cryo-EM structure of full-length TRPV1 at pH6c state | | 分子名称: | (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1r,2R,3S,4S,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate, Transient receptor potential cation channel subfamily V member 1 | | 著者 | Zhang, K, Julius, D, Cheng, Y. | | 登録日 | 2020-12-17 | | 公開日 | 2021-09-22 | | 最終更新日 | 2021-10-13 | | 実験手法 | ELECTRON MICROSCOPY (3.66 Å) | | 主引用文献 | Structural snapshots of TRPV1 reveal mechanism of polymodal functionality.
Cell, 184, 2021
|
|
6UW6
 | |
7K4D
 | | Cryo-EM structure of human TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor 3OG | | 分子名称: | 5-[(4-{trans-4-hydroxy-4-[3-(trifluoromethyl)phenyl]cyclohexyl}piperazin-1-yl)methyl]pyridin-2(1H)-one, CALCIUM ION, Transient receptor potential cation channel subfamily V member 6 | | 著者 | Neuberger, A, Nadezhdin, K.D, Singh, A.K, Sobolevsky, A.I. | | 登録日 | 2020-09-15 | | 公開日 | 2020-12-09 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.66 Å) | | 主引用文献 | Inactivation-mimicking block of the epithelial calcium channel TRPV6.
Sci Adv, 6, 2020
|
|
8V6L
 | | Open-state cryo-EM structure of human TRPV3 in presence of tetrahydrocannabivarin (THCV) in cNW30 nanodiscs | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, Tetrahydrocannabivarin, ... | | 著者 | Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | | 登録日 | 2023-12-01 | | 公開日 | 2024-04-17 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (3.68 Å) | | 主引用文献 | TRPV3 activation by different agonists accompanied by lipid dissociation from the vanilloid site.
Sci Adv, 10, 2024
|
|
7L2I
 | | Cryo-EM structure of full-length TRPV1 at pH6a state | | 分子名称: | (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1S,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate, Transient receptor potential cation channel subfamily V member 1 | | 著者 | Zhang, K, Julius, D, Cheng, Y. | | 登録日 | 2020-12-17 | | 公開日 | 2021-09-22 | | 最終更新日 | 2021-10-13 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structural snapshots of TRPV1 reveal mechanism of polymodal functionality.
Cell, 184, 2021
|
|
7T6L
 | |
7LPE
 | | Cryo-EM structure of full-length TRPV1 with capsaicin at 48 degrees Celsius, in an open state, class 1 | | 分子名称: | (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, ... | | 著者 | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | | 登録日 | 2021-02-11 | | 公開日 | 2021-07-28 | | 実験手法 | ELECTRON MICROSCOPY (3.72 Å) | | 主引用文献 | Heat-dependent opening of TRPV1 in the presence of capsaicin.
Nat.Struct.Mol.Biol., 28, 2021
|
|
7MZB
 | | Cryo-EM structure of minimal TRPV1 with 3 bound RTX and 1 perturbed PI | | 分子名称: | (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1r,2R,3S,4S,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate, SODIUM ION, Transient receptor potential cation channel subfamily V member 1, ... | | 著者 | Zhang, K, Julius, D, Cheng, Y. | | 登録日 | 2021-05-24 | | 公開日 | 2021-09-22 | | 最終更新日 | 2021-10-13 | | 実験手法 | ELECTRON MICROSCOPY (3.72 Å) | | 主引用文献 | Structural snapshots of TRPV1 reveal mechanism of polymodal functionality.
Cell, 184, 2021
|
|
8J1B
 | | GSK101 and Ruthenium Red bound state of mTRPV4 | | 分子名称: | N-[(2S)-1-{4-[N-(2,4-dichlorobenzene-1-sulfonyl)-L-seryl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide, Transient receptor potential cation channel subfamily V member 4, ruthenium(6+) azanide pentaamino(oxido)ruthenium (1/4/2) | | 著者 | Zhen, W.X, Yang, F. | | 登録日 | 2023-04-12 | | 公開日 | 2023-08-09 | | 実験手法 | ELECTRON MICROSCOPY (3.72 Å) | | 主引用文献 | Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel.
Cell Discov, 9, 2023
|
|
8FC9
 | | Cryo-EM structure of the human TRPV4 - RhoA, apo condition | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Transforming protein RhoA, ... | | 著者 | Kwon, D.H, Lee, S.-Y, Zhang, F. | | 登録日 | 2022-12-01 | | 公開日 | 2023-07-12 | | 実験手法 | ELECTRON MICROSCOPY (3.75 Å) | | 主引用文献 | TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease.
Nat Commun, 14, 2023
|
|
7K4F
 | | Cryo-EM structure of human TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor 31 | | 分子名称: | 5-[(4-{cis-4-[3-(trifluoromethyl)phenyl]cyclohexyl}piperazin-1-yl)methyl]pyridin-2(1H)-one, CALCIUM ION, Transient receptor potential cation channel subfamily V member 6 | | 著者 | Neuberger, A, Nadezhdin, K.D, Singh, A.K, Sobolevsky, A.I. | | 登録日 | 2020-09-15 | | 公開日 | 2020-12-09 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.75 Å) | | 主引用文献 | Inactivation-mimicking block of the epithelial calcium channel TRPV6.
Sci Adv, 6, 2020
|
|
6PBE
 | | ZINC17988990-bound TRPV5 in nanodiscs | | 分子名称: | (4-oxo-5-phenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)methyl 3-(3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)propanoate, Transient receptor potential cation channel subfamily V member 5 | | 著者 | Hughes, T.E.T, Rosario, J.S.D, Kapoor, A, Yazici, A.T, Fluck, E.C, Filizola, M, Rohacs, T, Moiseenkova-Bell, V.Y. | | 登録日 | 2019-06-13 | | 公開日 | 2019-11-06 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.78 Å) | | 主引用文献 | Structure-based characterization of novel TRPV5 inhibitors.
Elife, 8, 2019
|
|
7K4C
 | | Cryo-EM structure of human TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor Br-cis-22a | | 分子名称: | 1-(5-bromopyridin-3-yl)-4-[cis-4-(3-methylphenyl)cyclohexyl]piperazine, CALCIUM ION, Transient receptor potential cation channel subfamily V member 6 | | 著者 | Neuberger, A, Nadezhdin, K.D, Singh, A.K, Sobolevsky, A.I. | | 登録日 | 2020-09-15 | | 公開日 | 2020-12-09 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.78 Å) | | 主引用文献 | Inactivation-mimicking block of the epithelial calcium channel TRPV6.
Sci Adv, 6, 2020
|
|
3J5Q
 | | Structure of TRPV1 ion channel in complex with DkTx and RTX determined by single particle electron cryo-microscopy | | 分子名称: | Kappa-theraphotoxin-Cg1a 1, Transient receptor potential cation channel subfamily V member 1 | | 著者 | Liao, M, Cao, E, Julius, D, Cheng, Y. | | 登録日 | 2013-10-28 | | 公開日 | 2013-12-04 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | TRPV1 structures in distinct conformations reveal activation mechanisms.
Nature, 504, 2013
|
|
7B05
 | | TRPC4 in complex with inhibitor GFB-8749 | | 分子名称: | (2R)-3-(phosphonooxy)propane-1,2-diyl dihexanoate, 4-[4-[[4,4-bis(fluoranyl)cyclohexyl]methyl]-3-oxidanylidene-piperazin-1-yl]-5-chloranyl-1~{H}-pyridazin-6-one, CALCIUM ION, ... | | 著者 | Vinayagam, D, Quentin, D, Sistel, O, Merino, F, Stabrin, M, Hofnagel, O, Ledeboer, M.W, Malojcic, G, Raunser, S. | | 登録日 | 2020-11-18 | | 公開日 | 2020-12-09 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structural basis of TRPC4 regulation by calmodulin and pharmacological agents.
Elife, 9, 2020
|
|
7LR0
 | | Structure of squirrel TRPV1 in complex with capsaicin | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, Osm-9-like TRP channel 1, ... | | 著者 | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | | 登録日 | 2021-02-15 | | 公開日 | 2021-04-21 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.81 Å) | | 主引用文献 | Extracellular cap domain is an essential component of the TRPV1 gating mechanism.
Nat Commun, 12, 2021
|
|
7L2M
 | | Cryo-EM structure of DkTx/RTX-bound full-length TRPV1 | | 分子名称: | SODIUM ION, Tau-theraphotoxin-Hs1a, Transient receptor potential cation channel subfamily V member 1, ... | | 著者 | Zhang, K, Julius, D, Cheng, Y. | | 登録日 | 2020-12-17 | | 公開日 | 2021-09-22 | | 最終更新日 | 2021-10-13 | | 実験手法 | ELECTRON MICROSCOPY (3.84 Å) | | 主引用文献 | Structural snapshots of TRPV1 reveal mechanism of polymodal functionality.
Cell, 184, 2021
|
|
7MIL
 | | Mouse TRPV3 in MSP2N2 nanodiscs, sensitized state at 42 degrees Celsius | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, Transient receptor potential cation channel subfamily V member 3 | | 著者 | Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | | 登録日 | 2021-04-17 | | 公開日 | 2021-07-21 | | 最終更新日 | 2021-07-28 | | 実験手法 | ELECTRON MICROSCOPY (3.86 Å) | | 主引用文献 | Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel.
Nat.Struct.Mol.Biol., 28, 2021
|
|
8J1H
 | | Agonist1 and Ruthenium Red bound state of mTRPV4 | | 分子名称: | 8-fluoranyl-3-[4-(4-fluoranylphenoxy)phenyl]-2-(4-methylpiperazin-1-yl)quinazolin-4-one, Transient receptor potential cation channel subfamily V member 4 | | 著者 | Zhen, W.X, Yang, F. | | 登録日 | 2023-04-12 | | 公開日 | 2023-08-09 | | 実験手法 | ELECTRON MICROSCOPY (3.88 Å) | | 主引用文献 | Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel.
Cell Discov, 9, 2023
|
|
7L2K
 | |
6DMR
 | |
