7LPE

Cryo-EM structure of full-length TRPV1 with capsaicin at 48 degrees Celsius, in an open state, class 1

Summary for 7LPE

• Entry DOI: 10.2210/pdb7lpe/pdb
• EMDB information: 23479
• Descriptor: Transient receptor potential cation channel subfamily V member 1, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate, ... (4 entities in total)
• Functional Keywords: heat sensing ion channel, membrane protein
• Biological source: Rattus norvegicus (Rat)
• Total number of polymer chains: 4
• Total formula weight: 402012.97

Authors

Kwon, D.H.,Zhang, F.,Suo, Y.,Lee, S.-Y. (deposition date: 2021-02-11, release date: 2021-07-28)

• Primary citation: Kwon, D.H.,Zhang, F.,Suo, Y.,Bouvette, J.,Borgnia, M.J.,Lee, S.Y.; Heat-dependent opening of TRPV1 in the presence of capsaicin.; Nat.Struct.Mol.Biol., 28:554-563, 2021; PubMed: 34239123; DOI: 10.1038/s41594-021-00616-3

Experimental method

ELECTRON MICROSCOPY (3.72 Å)