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7LPE

Cryo-EM structure of full-length TRPV1 with capsaicin at 48 degrees Celsius, in an open state, class 1

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0001659biological_processtemperature homeostasis
A0001660biological_processfever generation
A0001774biological_processmicroglial cell activation
A0002024biological_processdiet induced thermogenesis
A0002790biological_processpeptide secretion
A0003085biological_processnegative regulation of systemic arterial blood pressure
A0004888molecular_functiontransmembrane signaling receptor activity
A0005216molecular_functionmonoatomic ion channel activity
A0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
A0005231molecular_functionexcitatory extracellular ligand-gated monoatomic ion channel activity
A0005261molecular_functionmonoatomic cation channel activity
A0005262molecular_functioncalcium channel activity
A0005515molecular_functionprotein binding
A0005516molecular_functioncalmodulin binding
A0005524molecular_functionATP binding
A0005886cellular_componentplasma membrane
A0006629biological_processlipid metabolic process
A0006811biological_processmonoatomic ion transport
A0006816biological_processcalcium ion transport
A0007204biological_processpositive regulation of cytosolic calcium ion concentration
A0008289molecular_functionlipid binding
A0008324molecular_functionmonoatomic cation transmembrane transporter activity
A0009268biological_processresponse to pH
A0009408biological_processresponse to heat
A0009897cellular_componentexternal side of plasma membrane
A0010243biological_processresponse to organonitrogen compound
A0010459biological_processnegative regulation of heart rate
A0010917biological_processnegative regulation of mitochondrial membrane potential
A0014047biological_processglutamate secretion
A0014832biological_processurinary bladder smooth muscle contraction
A0015276molecular_functionligand-gated monoatomic ion channel activity
A0015278molecular_functionintracellularly gated calcium channel activity
A0016020cellular_componentmembrane
A0017081molecular_functionchloride channel regulator activity
A0019233biological_processsensory perception of pain
A0019722biological_processcalcium-mediated signaling
A0030425cellular_componentdendrite
A0032591cellular_componentdendritic spine membrane
A0034220biological_processmonoatomic ion transmembrane transport
A0034605biological_processcellular response to heat
A0035091molecular_functionphosphatidylinositol binding
A0042802molecular_functionidentical protein binding
A0042995cellular_componentcell projection
A0043005cellular_componentneuron projection
A0043025cellular_componentneuronal cell body
A0043065biological_processpositive regulation of apoptotic process
A0043434biological_processresponse to peptide hormone
A0045202cellular_componentsynapse
A0045211cellular_componentpostsynaptic membrane
A0045429biological_processpositive regulation of nitric oxide biosynthetic process
A0046872molecular_functionmetal ion binding
A0048265biological_processresponse to pain
A0048266biological_processbehavioral response to pain
A0050954biological_processsensory perception of mechanical stimulus
A0050955biological_processthermoception
A0050960biological_processdetection of temperature stimulus involved in thermoception
A0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
A0050968biological_processdetection of chemical stimulus involved in sensory perception of pain
A0051219molecular_functionphosphoprotein binding
A0051289biological_processprotein homotetramerization
A0055085biological_processtransmembrane transport
A0060079biological_processexcitatory postsynaptic potential
A0060083biological_processsmooth muscle contraction involved in micturition
A0070588biological_processcalcium ion transmembrane transport
A0071312biological_processcellular response to alkaloid
A0071318biological_processcellular response to ATP
A0071345biological_processcellular response to cytokine stimulus
A0071356biological_processcellular response to tumor necrosis factor
A0071363biological_processcellular response to growth factor stimulus
A0071468biological_processcellular response to acidic pH
A0071502biological_processcellular response to temperature stimulus
A0090212biological_processnegative regulation of establishment of blood-brain barrier
A0097603molecular_functiontemperature-gated ion channel activity
A0098703biological_processcalcium ion import across plasma membrane
A1901594biological_processresponse to capsazepine
A1990090biological_processcellular response to nerve growth factor stimulus
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0001659biological_processtemperature homeostasis
B0001660biological_processfever generation
B0001774biological_processmicroglial cell activation
B0002024biological_processdiet induced thermogenesis
B0002790biological_processpeptide secretion
B0003085biological_processnegative regulation of systemic arterial blood pressure
B0004888molecular_functiontransmembrane signaling receptor activity
B0005216molecular_functionmonoatomic ion channel activity
B0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
B0005231molecular_functionexcitatory extracellular ligand-gated monoatomic ion channel activity
B0005261molecular_functionmonoatomic cation channel activity
B0005262molecular_functioncalcium channel activity
B0005515molecular_functionprotein binding
B0005516molecular_functioncalmodulin binding
B0005524molecular_functionATP binding
B0005886cellular_componentplasma membrane
B0006629biological_processlipid metabolic process
B0006811biological_processmonoatomic ion transport
B0006816biological_processcalcium ion transport
B0007204biological_processpositive regulation of cytosolic calcium ion concentration
B0008289molecular_functionlipid binding
B0008324molecular_functionmonoatomic cation transmembrane transporter activity
B0009268biological_processresponse to pH
B0009408biological_processresponse to heat
B0009897cellular_componentexternal side of plasma membrane
B0010243biological_processresponse to organonitrogen compound
B0010459biological_processnegative regulation of heart rate
B0010917biological_processnegative regulation of mitochondrial membrane potential
B0014047biological_processglutamate secretion
B0014832biological_processurinary bladder smooth muscle contraction
B0015276molecular_functionligand-gated monoatomic ion channel activity
B0015278molecular_functionintracellularly gated calcium channel activity
B0016020cellular_componentmembrane
B0017081molecular_functionchloride channel regulator activity
B0019233biological_processsensory perception of pain
B0019722biological_processcalcium-mediated signaling
B0030425cellular_componentdendrite
B0032591cellular_componentdendritic spine membrane
B0034220biological_processmonoatomic ion transmembrane transport
B0034605biological_processcellular response to heat
B0035091molecular_functionphosphatidylinositol binding
B0042802molecular_functionidentical protein binding
B0042995cellular_componentcell projection
B0043005cellular_componentneuron projection
B0043025cellular_componentneuronal cell body
B0043065biological_processpositive regulation of apoptotic process
B0043434biological_processresponse to peptide hormone
B0045202cellular_componentsynapse
B0045211cellular_componentpostsynaptic membrane
B0045429biological_processpositive regulation of nitric oxide biosynthetic process
B0046872molecular_functionmetal ion binding
B0048265biological_processresponse to pain
B0048266biological_processbehavioral response to pain
B0050954biological_processsensory perception of mechanical stimulus
B0050955biological_processthermoception
B0050960biological_processdetection of temperature stimulus involved in thermoception
B0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
B0050968biological_processdetection of chemical stimulus involved in sensory perception of pain
B0051219molecular_functionphosphoprotein binding
B0051289biological_processprotein homotetramerization
B0055085biological_processtransmembrane transport
B0060079biological_processexcitatory postsynaptic potential
B0060083biological_processsmooth muscle contraction involved in micturition
B0070588biological_processcalcium ion transmembrane transport
B0071312biological_processcellular response to alkaloid
B0071318biological_processcellular response to ATP
B0071345biological_processcellular response to cytokine stimulus
B0071356biological_processcellular response to tumor necrosis factor
B0071363biological_processcellular response to growth factor stimulus
B0071468biological_processcellular response to acidic pH
B0071502biological_processcellular response to temperature stimulus
B0090212biological_processnegative regulation of establishment of blood-brain barrier
B0097603molecular_functiontemperature-gated ion channel activity
B0098703biological_processcalcium ion import across plasma membrane
B1901594biological_processresponse to capsazepine
B1990090biological_processcellular response to nerve growth factor stimulus
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0001659biological_processtemperature homeostasis
C0001660biological_processfever generation
C0001774biological_processmicroglial cell activation
C0002024biological_processdiet induced thermogenesis
C0002790biological_processpeptide secretion
C0003085biological_processnegative regulation of systemic arterial blood pressure
C0004888molecular_functiontransmembrane signaling receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
C0005231molecular_functionexcitatory extracellular ligand-gated monoatomic ion channel activity
C0005261molecular_functionmonoatomic cation channel activity
C0005262molecular_functioncalcium channel activity
C0005515molecular_functionprotein binding
C0005516molecular_functioncalmodulin binding
C0005524molecular_functionATP binding
C0005886cellular_componentplasma membrane
C0006629biological_processlipid metabolic process
C0006811biological_processmonoatomic ion transport
C0006816biological_processcalcium ion transport
C0007204biological_processpositive regulation of cytosolic calcium ion concentration
C0008289molecular_functionlipid binding
C0008324molecular_functionmonoatomic cation transmembrane transporter activity
C0009268biological_processresponse to pH
C0009408biological_processresponse to heat
C0009897cellular_componentexternal side of plasma membrane
C0010243biological_processresponse to organonitrogen compound
C0010459biological_processnegative regulation of heart rate
C0010917biological_processnegative regulation of mitochondrial membrane potential
C0014047biological_processglutamate secretion
C0014832biological_processurinary bladder smooth muscle contraction
C0015276molecular_functionligand-gated monoatomic ion channel activity
C0015278molecular_functionintracellularly gated calcium channel activity
C0016020cellular_componentmembrane
C0017081molecular_functionchloride channel regulator activity
C0019233biological_processsensory perception of pain
C0019722biological_processcalcium-mediated signaling
C0030425cellular_componentdendrite
C0032591cellular_componentdendritic spine membrane
C0034220biological_processmonoatomic ion transmembrane transport
C0034605biological_processcellular response to heat
C0035091molecular_functionphosphatidylinositol binding
C0042802molecular_functionidentical protein binding
C0042995cellular_componentcell projection
C0043005cellular_componentneuron projection
C0043025cellular_componentneuronal cell body
C0043065biological_processpositive regulation of apoptotic process
C0043434biological_processresponse to peptide hormone
C0045202cellular_componentsynapse
C0045211cellular_componentpostsynaptic membrane
C0045429biological_processpositive regulation of nitric oxide biosynthetic process
C0046872molecular_functionmetal ion binding
C0048265biological_processresponse to pain
C0048266biological_processbehavioral response to pain
C0050954biological_processsensory perception of mechanical stimulus
C0050955biological_processthermoception
C0050960biological_processdetection of temperature stimulus involved in thermoception
C0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
C0050968biological_processdetection of chemical stimulus involved in sensory perception of pain
C0051219molecular_functionphosphoprotein binding
C0051289biological_processprotein homotetramerization
C0055085biological_processtransmembrane transport
C0060079biological_processexcitatory postsynaptic potential
C0060083biological_processsmooth muscle contraction involved in micturition
C0070588biological_processcalcium ion transmembrane transport
C0071312biological_processcellular response to alkaloid
C0071318biological_processcellular response to ATP
C0071345biological_processcellular response to cytokine stimulus
C0071356biological_processcellular response to tumor necrosis factor
C0071363biological_processcellular response to growth factor stimulus
C0071468biological_processcellular response to acidic pH
C0071502biological_processcellular response to temperature stimulus
C0090212biological_processnegative regulation of establishment of blood-brain barrier
C0097603molecular_functiontemperature-gated ion channel activity
C0098703biological_processcalcium ion import across plasma membrane
C1901594biological_processresponse to capsazepine
C1990090biological_processcellular response to nerve growth factor stimulus
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0001659biological_processtemperature homeostasis
D0001660biological_processfever generation
D0001774biological_processmicroglial cell activation
D0002024biological_processdiet induced thermogenesis
D0002790biological_processpeptide secretion
D0003085biological_processnegative regulation of systemic arterial blood pressure
D0004888molecular_functiontransmembrane signaling receptor activity
D0005216molecular_functionmonoatomic ion channel activity
D0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
D0005231molecular_functionexcitatory extracellular ligand-gated monoatomic ion channel activity
D0005261molecular_functionmonoatomic cation channel activity
D0005262molecular_functioncalcium channel activity
D0005515molecular_functionprotein binding
D0005516molecular_functioncalmodulin binding
D0005524molecular_functionATP binding
D0005886cellular_componentplasma membrane
D0006629biological_processlipid metabolic process
D0006811biological_processmonoatomic ion transport
D0006816biological_processcalcium ion transport
D0007204biological_processpositive regulation of cytosolic calcium ion concentration
D0008289molecular_functionlipid binding
D0008324molecular_functionmonoatomic cation transmembrane transporter activity
D0009268biological_processresponse to pH
D0009408biological_processresponse to heat
D0009897cellular_componentexternal side of plasma membrane
D0010243biological_processresponse to organonitrogen compound
D0010459biological_processnegative regulation of heart rate
D0010917biological_processnegative regulation of mitochondrial membrane potential
D0014047biological_processglutamate secretion
D0014832biological_processurinary bladder smooth muscle contraction
D0015276molecular_functionligand-gated monoatomic ion channel activity
D0015278molecular_functionintracellularly gated calcium channel activity
D0016020cellular_componentmembrane
D0017081molecular_functionchloride channel regulator activity
D0019233biological_processsensory perception of pain
D0019722biological_processcalcium-mediated signaling
D0030425cellular_componentdendrite
D0032591cellular_componentdendritic spine membrane
D0034220biological_processmonoatomic ion transmembrane transport
D0034605biological_processcellular response to heat
D0035091molecular_functionphosphatidylinositol binding
D0042802molecular_functionidentical protein binding
D0042995cellular_componentcell projection
D0043005cellular_componentneuron projection
D0043025cellular_componentneuronal cell body
D0043065biological_processpositive regulation of apoptotic process
D0043434biological_processresponse to peptide hormone
D0045202cellular_componentsynapse
D0045211cellular_componentpostsynaptic membrane
D0045429biological_processpositive regulation of nitric oxide biosynthetic process
D0046872molecular_functionmetal ion binding
D0048265biological_processresponse to pain
D0048266biological_processbehavioral response to pain
D0050954biological_processsensory perception of mechanical stimulus
D0050955biological_processthermoception
D0050960biological_processdetection of temperature stimulus involved in thermoception
D0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
D0050968biological_processdetection of chemical stimulus involved in sensory perception of pain
D0051219molecular_functionphosphoprotein binding
D0051289biological_processprotein homotetramerization
D0055085biological_processtransmembrane transport
D0060079biological_processexcitatory postsynaptic potential
D0060083biological_processsmooth muscle contraction involved in micturition
D0070588biological_processcalcium ion transmembrane transport
D0071312biological_processcellular response to alkaloid
D0071318biological_processcellular response to ATP
D0071345biological_processcellular response to cytokine stimulus
D0071356biological_processcellular response to tumor necrosis factor
D0071363biological_processcellular response to growth factor stimulus
D0071468biological_processcellular response to acidic pH
D0071502biological_processcellular response to temperature stimulus
D0090212biological_processnegative regulation of establishment of blood-brain barrier
D0097603molecular_functiontemperature-gated ion channel activity
D0098703biological_processcalcium ion import across plasma membrane
D1901594biological_processresponse to capsazepine
D1990090biological_processcellular response to nerve growth factor stimulus
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2432
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200
ChainResidueDetails
CMET1-ARG432
CGLN498-SER510
CARG557-LYS571
CASN687-LYS838
BMET1-ARG432
BGLN498-SER510
BARG557-LYS571
BASN687-LYS838
AMET1-ARG432
AGLN498-SER510
AARG557-LYS571
AASN687-LYS838
DMET1-ARG432
DGLN498-SER510
DARG557-LYS571
DASN687-LYS838

site_idSWS_FT_FI2
Number of Residues560
DetailsTRANSMEM: Helical => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200
ChainResidueDetails
CILE433-TYR453
CTYR472-LEU497
CTYR511-PHE531
CGLU536-THR556
CMET572-ILE599
CVAL658-VAL686
BILE433-TYR453
BTYR472-LEU497
BTYR511-PHE531
BGLU536-THR556
BMET572-ILE599
BVAL658-VAL686
AILE433-TYR453
ATYR472-LEU497
ATYR511-PHE531
AGLU536-THR556
AMET572-ILE599
AVAL658-VAL686
DILE433-TYR453
DTYR472-LEU497
DTYR511-PHE531
DGLU536-THR556
DMET572-ILE599
DVAL658-VAL686

site_idSWS_FT_FI3
Number of Residues184
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200
ChainResidueDetails
CTYR454-ASP471
CSER532-LYS535
CGLU600-SER626
BTYR454-ASP471
BSER532-LYS535
BGLU600-SER626
ATYR454-ASP471
ASER532-LYS535
AGLU600-SER626
DTYR454-ASP471
DSER532-LYS535
DGLU600-SER626

site_idSWS_FT_FI4
Number of Residues88
DetailsINTRAMEM: Pore-forming => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200, ECO:0000305|PubMed:10931826
ChainResidueDetails
CTYR627-PHE649
BTYR627-PHE649
ATYR627-PHE649
DTYR627-PHE649

site_idSWS_FT_FI5
Number of Residues12
DetailsBINDING: BINDING => ECO:0007744|PDB:2PNN
ChainResidueDetails
BLYS155
BGLU210
AARG115
ALYS155
AGLU210
DARG115
DLYS155
DGLU210
CARG115
CLYS155
CGLU210
BARG115

site_idSWS_FT_FI6
Number of Residues12
DetailsBINDING: BINDING => ECO:0007744|PDB:2NYJ, ECO:0007744|PDB:2PNN
ChainResidueDetails
BASN164
BTYR199
ALYS160
AASN164
ATYR199
DLYS160
DASN164
DTYR199
CASN164
CTYR199
BLYS160
CLYS160

site_idSWS_FT_FI7
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:27281200, ECO:0007744|PDB:5IRX
ChainResidueDetails
BTHR550
BARG557
ATYR511
ATHR550
AARG557
DTYR511
DTHR550
DARG557
CTYR511
CTHR550
CARG557
BTYR511

site_idSWS_FT_FI8
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q9R186
ChainResidueDetails
AASP646
DASP646
CASP646
BASP646

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PKA and PKD => ECO:0000269|PubMed:12194871, ECO:0000269|PubMed:15471852
ChainResidueDetails
BSER116
ASER116
DSER116
CSER116

site_idSWS_FT_FI10
Number of Residues8
DetailsMOD_RES: Phosphothreonine; by PKA; in vitro => ECO:0000269|PubMed:12194871
ChainResidueDetails
BTHR144
BTHR370
ATHR144
ATHR370
DTHR144
DTHR370
CTHR144
CTHR370

site_idSWS_FT_FI11
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PKC/PRKCE => ECO:0000269|PubMed:11884385, ECO:0000269|PubMed:12194871, ECO:0000269|PubMed:14630912
ChainResidueDetails
BSER502
ASER502
DSER502
CSER502

site_idSWS_FT_FI12
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:14630912
ChainResidueDetails
BTHR704
ATHR704
DTHR704
CTHR704

site_idSWS_FT_FI13
Number of Residues8
DetailsMOD_RES: Phosphoserine; by PKA; in vitro => ECO:0000269|PubMed:12194871
ChainResidueDetails
ASER774
ASER820
DSER774
DSER820
BSER774
BSER820
CSER774
CSER820

site_idSWS_FT_FI14
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PKC/PRKCE and PKC/PRKCZ => ECO:0000269|PubMed:11884385
ChainResidueDetails
BSER800
ASER800
DSER800
CSER800

site_idSWS_FT_FI15
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11683872
ChainResidueDetails
BASN604
AASN604
DASN604
CASN604

219869

PDB entries from 2024-05-15

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