PDB: 593 件ウェブページステータス検索Chemie searchBIRD

---

8DCP	PI 3-kinase alpha with nanobody 3-126 分子名称: Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 著者 Hart, J.R, Liu, X, Pan, C, Liang, A, Ueno, L, Xu, Y, Quezada, A, Zou, X, Yang, S, Zhou, Q, Schoonooghe, S, Hassanzadeh-Ghassabeh, G, Xia, T, Shui, W, Yang, D, Vogt, P.K, Wang, M.-W. 登録日 2022-06-17 公開日 2022-09-21 実験手法 ELECTRON MICROSCOPY (2.41 Å) 主引用文献 Nanobodies and chemical cross-links advance the structural and functional analysis of PI3K alpha. Proc.Natl.Acad.Sci.USA, 119, 2022
7TZ7	PI3K alpha in complex with an inhibitor 分子名称: (4S,5R)-3-[2'-amino-2-(morpholin-4-yl)-4'-(trifluoromethyl)[4,5'-bipyrimidin]-6-yl]-4-(hydroxymethyl)-5-methyl-1,3-oxazolidin-2-one, Isoform 3 of Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 著者 Knapp, M.S, Tang, J. 登録日 2022-02-15 公開日 2022-05-18 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 Identification of NVP-CLR457 as an Orally Bioavailable Non-CNS-Penetrant pan-Class IA Phosphoinositol-3-Kinase Inhibitor. J.Med.Chem., 65, 2022
3PQZ	Grb7 SH2 with peptide 分子名称: Growth factor receptor-bound protein 7, cyclic peptide 著者 Wilce, J.A. 登録日 2010-11-29 公開日 2011-07-20 最終更新日 2011-09-21 実験手法 X-RAY DIFFRACTION (2.413 Å) 主引用文献 Structural basis of binding by cyclic nonphosphorylated Peptide antagonists of grb7 implicated in breast cancer progression J.Mol.Biol., 412, 2011
6F3F	Autoinhibited Src kinase bound to ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Tyrosine-protein kinase 著者 von Raussendorf, F, Leonard, T.A. 登録日 2017-11-28 公開日 2017-12-27 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.41795778 Å) 主引用文献 A switch in nucleotide affinity governs activation of the Src and Tec family kinases. Sci Rep, 7, 2017
6BMX	Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor SHP844 分子名称: 1-(3-chloro-4-{[1-(2-hydroxy-3-methoxyphenyl)-5-oxo[1,2,4]triazolo[4,3-a]quinazolin-4(5H)-yl]methyl}benzene-1-carbonyl)-L-proline, GLYCEROL, PHOSPHATE ION, ... 著者 Stams, T, Fodor, M. 登録日 2017-11-15 公開日 2018-01-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.424 Å) 主引用文献 Dual Allosteric Inhibition of SHP2 Phosphatase. ACS Chem. Biol., 13, 2018
7WFY	Crystal Structure of the VAV2 SH2 domain in complex with APP phosphorylated peptide 分子名称: Amyloid beta A4 protein-binding family B member 1 (protein), Guanine nucleotide exchange factor VAV2 著者 Zhang, Y.J, Liu, Y.R, Wu, B. 登録日 2021-12-27 公開日 2022-12-07 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.449 Å) 主引用文献 Vav2 is a novel APP-interacting protein that regulates APP protein level. Sci Rep, 12, 2022
5X7B	Crystal structure of SHP2_SH2-CagA EPIYA_C peptide complex 分子名称: CagA, Tyrosine-protein phosphatase non-receptor type 11 著者 Senda, M, Senda, T. 登録日 2017-02-24 公開日 2017-09-13 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Differential Mechanisms for SHP2 Binding and Activation Are Exploited by Geographically Distinct Helicobacter pylori CagA Oncoproteins. Cell Rep, 20, 2017
4NWG	Crystal structure of the tyrosine phosphatase SHP-2 with E139D mutation 分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, SULFATE ION, ... 著者 Qiu, W, Lin, A, Hutchinson, A, Romanov, V, Ruzanov, M, Thompson, C, Lam, K, Kisselman, G, Battalie, K, Chirgadze, N.Y. 登録日 2013-12-06 公開日 2014-12-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Crystal structure of the tyrosine phosphatase SHP-2 with E139D mutation To be Published
6PBC	Structural basis for the activation of PLC-gamma isozymes by phosphorylation and cancer-associated mutations 分子名称: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma,1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, CALCIUM ION, SODIUM ION 著者 Hajicek, N, Sondek, J. 登録日 2019-06-13 公開日 2020-01-08 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.46 Å) 主引用文献 Structural basis for the activation of PLC-gamma isozymes by phosphorylation and cancer-associated mutations. Elife, 8, 2019
3VS1	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 1-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-phenylurea 分子名称: 1-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-phenylurea, CALCIUM ION, CHLORIDE ION, ... 著者 Kuratani, M, Tomabechi, Y, Toyama, M, Handa, N, Yokoyama, S. 登録日 2012-04-21 公開日 2013-05-01 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.464 Å) 主引用文献 A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
5EEL	Grb7 SH2 with bicyclic peptide inhibitor 分子名称: Bicyclic Peptide Inhibitor, FORMIC ACID, Growth factor receptor-bound protein 7, ... 著者 Watson, G.M, Gunzburg, M.J, Wilce, M.C.J, Wilce, J.A. 登録日 2015-10-23 公開日 2016-06-15 最終更新日 2018-12-26 実験手法 X-RAY DIFFRACTION (2.47 Å) 主引用文献 Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7. Sci Rep, 6, 2016
3VRY	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 4-Amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane 分子名称: 4-Amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane, CALCIUM ION, CHLORIDE ION, ... 著者 Kuratani, M, Tomabechi, Y, Niwa, H, Handa, N, Yokoyama, S. 登録日 2012-04-21 公開日 2013-05-01 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.481 Å) 主引用文献 A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
6C7Y	Crystal structure of inhibitory protein SOCS1 in complex with JAK1 kinase domain 分子名称: 1,2-ETHANEDIOL, ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, ... 著者 Liau, N.P.D, Laktyushin, A, Lucet, I.S, Murphy, J.M, Yao, S, Callaghan, K, Nicola, N.A, Kershaw, N.J, Babon, J.J. 登録日 2018-01-23 公開日 2018-05-02 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.499 Å) 主引用文献 The molecular basis of JAK/STAT inhibition by SOCS1. Nat Commun, 9, 2018
7PG6	Crystal Structure of PI3Kalpha in complex with the inhibitor NVP-BYL719 分子名称: (2S)-N~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, ... 著者 Gong, G, Pinotsis, N, Williams, R.L, Vanhaesebroeck, B. 登録日 2021-08-13 公開日 2022-08-24 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.49943733 Å) 主引用文献 A small-molecule PI3K alpha activator for cardioprotection and neuroregeneration. Nature, 618, 2023
1JWO	Crystal Structure Analysis of the SH2 Domain of the Csk Homologous Kinase CHK 分子名称: Csk Homologous Kinase 著者 Murthy, T.V.S, Webster, G.D. 登録日 2001-09-04 公開日 2001-09-12 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Recognition of the HER-2/neu Receptor by the SH2 Domain of the Csk Homologous Kinase To be Published
1K9A	Crystal structure analysis of full-length carboxyl-terminal Src kinase at 2.5 A resolution 分子名称: Carboxyl-terminal Src kinase 著者 Ogawa, A, Takayama, Y, Nagata, A, Chong, K.T, Takeuchi, S, Sakai, H, Nakagawa, A, Nada, S, Okada, M, Tsukihara, T. 登録日 2001-10-28 公開日 2002-03-20 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure of the carboxyl-terminal Src kinase, Csk. J.Biol.Chem., 277, 2002
5FI4	Discovery of imidazo[1,2-a]-pyridine inhibitors of pan-PI3 kinases that are efficacious in a mouse xenograft model 分子名称: GLYCEROL, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, ... 著者 Elling, R.A, Knapp, M.S, Han, W, Daniel, L.M, Xy, Y, Burger, M.T, Ni, Z, Smith, A, Lan, J, Williams, T, Verhagen, J, Huh, K, Merritt, H, Chan, J, Kaufman, S, Voliva, C.F, Pecchi, S. 登録日 2015-12-22 公開日 2016-02-03 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Discovery of imidazo[1,2-a]-pyridine inhibitors of pan-PI3 kinases that are efficacious in a mouse xenograft model. Bioorg.Med.Chem.Lett., 26, 2016
1LCK	SH3-SH2 DOMAIN FRAGMENT OF HUMAN P56-LCK TYROSINE KINASE COMPLEXED WITH THE 10 RESIDUE SYNTHETIC PHOSPHOTYROSYL PEPTIDE TEGQPYQPQPA 分子名称: P56==LCK== TYROSINE KINASE, TAIL PHOSPHOPEPTIDE TEGQ(PHOSPHO)YQPQPA 著者 Eck, M, Harrison, S. 登録日 1994-12-12 公開日 1995-10-15 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure of the regulatory domains of the Src-family tyrosine kinase Lck. Nature, 368, 1994
2DX0	Crystal structure of the N-terminal SH2 domain of mouse phospholipase C-gamma 2 分子名称: Phospholipase C, gamma 2, SULFATE ION 著者 Handa, N, Takagi, T, Murayama, K, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2006-08-22 公開日 2007-09-04 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of the N-terminal SH2 domain of mouse phospholipase C-gamma 2 To be Published
1M27	Crystal structure of SAP/FynSH3/SLAM ternary complex 分子名称: CITRATE ANION, Proto-oncogene tyrosine-protein kinase FYN, SH2 domain protein 1A, ... 著者 Chan, B, Griesbach, J, Song, H.K, Poy, F, Terhorst, C, Eck, M.J. 登録日 2002-06-21 公開日 2003-05-06 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 SAP couples Fyn to SLAM immune receptors. NAT.CELL BIOL., 5, 2003
1M61	Crystal structure of the apo SH2 domains of ZAP-70 分子名称: PHOSPHATE ION, TYROSINE-PROTEIN KINASE ZAP-70 著者 Folmer, R.H.A, Geschwindner, S, Xue, Y. 登録日 2002-07-11 公開日 2003-07-15 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure and NMR studies of the apo SH2 domains of ZAP-70: two bikes rather than a tandem Biochemistry, 41, 2002
5UK8	The co-structure of (R)-4-(6-(1-(cyclopropylsulfonyl)cyclopropyl)-2-(1H-indol-4-yl)pyrimidin-4-yl)-3-methylmorpholine and a rationally designed PI3K-alpha mutant that mimics ATR 分子名称: (R)-4-(6-(1-(cyclopropylsulfonyl)cyclopropyl)-2-(1H-indol-4-yl)pyrimidin-4-yl)-3-methylmorpholine, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 著者 Knapp, M.S, Mamo, M, Elling, R.A. 登録日 2017-01-20 公開日 2017-06-14 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Rationally Designed PI3K alpha Mutants to Mimic ATR and Their Use to Understand Binding Specificity of ATR Inhibitors. J. Mol. Biol., 429, 2017
1SPR	BINDING OF A HIGH AFFINITY PHOSPHOTYROSYL PEPTIDE TO THE SRC SH2 DOMAIN: CRYSTAL STRUCTURES OF THE COMPLEXED AND PEPTIDE-FREE FORMS 分子名称: PHOSPHATE ION, SRC TYROSINE KINASE SH2 DOMAIN 著者 Waksman, G, Kuriyan, J. 登録日 1993-03-05 公開日 1994-05-31 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms. Cell(Cambridge,Mass.), 72, 1993
6ATD	Oxidized SHP2 forms a disulfide bond between Cys367 and Cys459 分子名称: PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 11 著者 Page, R, Peti, W, Critton, D.A. 登録日 2017-08-28 公開日 2018-07-11 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Redox Regulation of a Gain-of-Function Mutation (N308D) in SHP2 Noonan Syndrome. ACS Omega, 2, 2017
3GQI	Crystal Structure of activated receptor tyrosine kinase in complex with substrates 分子名称: Basic fibroblast growth factor receptor 1, DECAVANADATE, MAGNESIUM ION, ... 著者 Bae, J.H, Lew, E.D, Yuzawa, S, Tome, F, Lax, I, Schlessinger, J. 登録日 2009-03-24 公開日 2009-08-18 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site. Cell(Cambridge,Mass.), 138, 2009

<6789101112131415161718192021>