9PTI
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8PTI
| CRYSTAL STRUCTURE OF A Y35G MUTANT OF BOVINE PANCREATIC TRYPSIN INHIBITOR | 分子名称: | BOVINE PANCREATIC TRYPSIN INHIBITOR | 著者 | Housset, D, Kim, K.-S, Fuchs, J, Woodward, C, Wlodawer, A. | 登録日 | 1990-12-17 | 公開日 | 1991-04-15 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structure of a Y35G mutant of bovine pancreatic trypsin inhibitor. J.Mol.Biol., 220, 1991
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8OTF
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7V1N
| Structure of the Clade 2 C. difficile TcdB in complex with its receptor TFPI | 分子名称: | Isoform Beta of Tissue factor pathway inhibitor, Toxin B | 著者 | Luo, J, Yang, Q, Zhang, X, Zhang, Y, Wan, L, Li, Y, Tao, L. | 登録日 | 2021-08-05 | 公開日 | 2022-02-23 | 最終更新日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | TFPI is a colonic crypt receptor for TcdB from hypervirulent clade 2 C. difficile. Cell, 185, 2022
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7QIT
| CRYSTAL STRUCTURE OF THE P1 trifluoroethylglycine (TfeGly) BPTI MUTANT- BOVINE CHYMOTRYPSIN COMPLEX | 分子名称: | Chymotrypsin A chain A, Chymotrypsin A chain B, Chymotrypsin A chain C, ... | 著者 | Dimos, N, Leppkes, J, Koksch, B, Wahl, M.C, Loll, B. | 登録日 | 2021-12-15 | 公開日 | 2022-03-09 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Fluorine-induced polarity increases inhibitory activity of BPTI towards chymotrypsin. Rsc Chem Biol, 3, 2022
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7QIS
| CRYSTAL STRUCTURE OF THE P1 difluoroethylglycine (DfeGly) BPTI MUTANT- BOVINE CHYMOTRYPSIN COMPLEX | 分子名称: | Chymotrypsin A chain A, Chymotrypsin A chain B, Chymotrypsin A chain C, ... | 著者 | Dimos, N, Leppkes, J, Koksch, B, Wahl, M.C, Loll, B. | 登録日 | 2021-12-15 | 公開日 | 2022-03-09 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | Fluorine-induced polarity increases inhibitory activity of BPTI towards chymotrypsin. Rsc Chem Biol, 3, 2022
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7QIR
| CRYSTAL STRUCTURE OF THE P1 monofluorethylglycine(MfeGly) BPTI MUTANT- BOVINE CHYMOTRYPSIN COMPLEX | 分子名称: | Chymotrypsin A chain A, Chymotrypsin A chain B, Chymotrypsin A chain C, ... | 著者 | Dimos, N, Leppkes, J, Koksch, B, Wahl, M.C, Loll, B. | 登録日 | 2021-12-15 | 公開日 | 2022-03-09 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Fluorine-induced polarity increases inhibitory activity of BPTI towards chymotrypsin. Rsc Chem Biol, 3, 2022
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7QIQ
| CRYSTAL STRUCTURE OF THE P1 aminobutanoic acid (ABU) BPTI MUTANT- BOVINE CHYMOTRYPSIN COMPLEX | 分子名称: | Chymotrypsin A chain A, Chymotrypsin A chain B, Chymotrypsin A chain C, ... | 著者 | Dimos, N, Leppkes, J, Koksch, B, Wahl, M.C, Loll, B. | 登録日 | 2021-12-15 | 公開日 | 2022-03-09 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Fluorine-induced polarity increases inhibitory activity of BPTI towards chymotrypsin. Rsc Chem Biol, 3, 2022
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7PTI
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7PH1
| Trypsin in complex with BPTI mutant (2S)-2-amino-4-monofluorobutanoic acid | 分子名称: | CALCIUM ION, Cationic trypsin, GLYCEROL, ... | 著者 | Dimos, N, Leppkes, J, Koksch, B, Loll, B. | 登録日 | 2021-08-16 | 公開日 | 2022-03-30 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.18 Å) | 主引用文献 | Water Network in the Binding Pocket of Fluorinated BPTI-Trypsin Complexes─Insights from Simulation and Experiment. J.Phys.Chem.B, 126, 2022
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6YHY
| A lid blocking mechanism of a cone snail toxin revealed at the atomic level | 分子名称: | Conk-S1 | 著者 | Saikia, C, Altman-Gueta, H, Dym, O, Frolow, F, Gurevitz, M, Gordon, D, Reuveny, E, Karbat, I. | 登録日 | 2020-03-31 | 公開日 | 2021-04-14 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | A Molecular Lid Mechanism of K + Channel Blocker Action Revealed by a Cone Peptide. J.Mol.Biol., 433, 2021
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6Q6C
| Pore-modulating toxins exploit inherent slow inactivation to block K+ channels | 分子名称: | 1,2-ETHANEDIOL, Kunitz-type conkunitzin-S1, NITRATE ION, ... | 著者 | Karbat, I, Gueta, H, Fine, S, Szanto, T, Hamer-Rogotner, S, Dym, O, Frolow, F, Gordon, D, Panyi, G, Gurevitz, M, Reuveny, E. | 登録日 | 2018-12-10 | 公開日 | 2019-08-21 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Pore-modulating toxins exploit inherent slow inactivation to block K+channels. Proc.Natl.Acad.Sci.USA, 116, 2019
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6Q61
| Pore-modulating toxins exploit inherent slow inactivation to block K+ channels | 分子名称: | Kunitz-type conkunitzin-S1, SULFATE ION | 著者 | Karbat, I, Gueta, H, Fine, S, Szanto, T, Hamer-Rogotner, S, Dym, O, Frolow, F, Gordon, D, Panyi, G, Gurevitz, M, Reuveny, E. | 登録日 | 2018-12-10 | 公開日 | 2019-08-21 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Pore-modulating toxins exploit inherent slow inactivation to block K+channels. Proc.Natl.Acad.Sci.USA, 116, 2019
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6PTI
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6NAN
| NMR structure determination of Ixolaris and Factor X interaction reveals a noncanonical mechanism of Kunitz inhibition | 分子名称: | Ixolaris | 著者 | De Paula, V.S, Sgourakis, N.G, Francischetti, I.M.B, Almeida, F.C.L, Monteiro, R.Q, Valente, A.P. | 登録日 | 2018-12-06 | 公開日 | 2019-06-12 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR structure determination of Ixolaris and factor X(a) interaction reveals a noncanonical mechanism of Kunitz inhibition. Blood, 134, 2019
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6KZF
| Racemic X-ray Structure of Calcicludine | 分子名称: | D-calcicludine, Kunitz-type serine protease inhibitor homolog calcicludine | 著者 | Qu, Q, Gao, S, Liu, L. | 登録日 | 2019-09-24 | 公開日 | 2019-11-06 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | 主引用文献 | Synthesis of Disulfide Surrogate Peptides Incorporating Large-Span Surrogate Bridges Through a Native-Chemical-Ligation-Assisted Diaminodiacid Strategy Angew.Chem.Int.Ed.Engl., 59, 2020
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6HAR
| Crystal structure of Mesotrypsin in complex with APPI-M17C/I18F/F34C | 分子名称: | 1,2-ETHANEDIOL, Amyloid-beta A4 protein, CALCIUM ION, ... | 著者 | Shahar, A, Cohen, I, Radisky, E, Papo, N. | 登録日 | 2018-08-08 | 公開日 | 2019-02-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.497 Å) | 主引用文献 | Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin. J.Biol.Chem., 294, 2019
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6GFI
| Structure of Human Mesotrypsin in complex with APPI variant T11V/M17R/I18F/F34V | 分子名称: | 1,2-ETHANEDIOL, Amyloid-beta A4 protein, PRSS3 protein | 著者 | Shahar, A, Cohen, I, Radisky, E, Papo, N, Naftaly, S. | 登録日 | 2018-04-30 | 公開日 | 2018-09-12 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries. Nat Commun, 9, 2018
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6F1F
| The methylene thioacetal BPTI (Bovine Pancreatic Trypsin Inhibitor) mutant structure | 分子名称: | GLYCEROL, Pancreatic trypsin inhibitor, SULFATE ION | 著者 | Lansky, S, Mousa, R, Metanis, N, Shoham, G. | 登録日 | 2017-11-21 | 公開日 | 2018-07-18 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.716 Å) | 主引用文献 | BPTI folding revisited: switching a disulfide into methylene thioacetal reveals a previously hidden path. Chem Sci, 9, 2018
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6BX8
| Human Mesotrypsin (PRSS3) Complexed with Tissue Factor Pathway Inhibitor Variant (TFPI1-KD1-K15R-I17C-I34C) | 分子名称: | SULFATE ION, Tissue factor pathway inhibitor, Trypsin-3 | 著者 | Coban, M, Sankaran, B, Cohen, I, Hockla, A, Papo, N, Radisky, E.S. | 登録日 | 2017-12-18 | 公開日 | 2019-02-06 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin. J. Biol. Chem., 294, 2019
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6A5I
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5ZJ3
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5YW1
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5YVU
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5YV7
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