4V9J
 
 | | 70S ribosome translocation intermediate GDPNP-II containing elongation factor EFG/GDPNP, mRNA, and tRNA bound in the pe*/E state. | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Zhou, J, Lancaster, L, Donohue, J.P, Noller, H.F. | | 登録日 | 2013-04-23 | | 公開日 | 2014-07-09 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (3.86 Å) | | 主引用文献 | Crystal structures of EF-G-ribosome complexes trapped in intermediate states of translocation.
Science, 340, 2013
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4V89
 | | Crystal Structure of Release Factor RF3 Trapped in the GTP State on a Rotated Conformation of the Ribosome (without viomycin) | | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | 著者 | Zhou, J, Lancaster, L, Trakhanov, S, Noller, H.F. | | 登録日 | 2011-11-17 | | 公開日 | 2014-07-09 | | 最終更新日 | 2019-07-17 | | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | | 主引用文献 | Crystal structure of release factor RF3 trapped in the GTP state on a rotated conformation of the ribosome.
Rna, 18, 2012
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4V8Z
 | | Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex | | 分子名称: | 18S RIBOSOMAL RNA, 25S RIBOSOMAL RNA, 40S RIBOSOMAL PROTEIN S0-A, ... | | 著者 | Fernandez, I.S, Bai, X.C, Hussain, T, Kelley, A.C, Lorsch, J.R, Ramakrishnan, V, Scheres, S.H.W. | | 登録日 | 2013-07-20 | | 公開日 | 2014-07-09 | | 最終更新日 | 2023-03-01 | | 実験手法 | ELECTRON MICROSCOPY (6.6 Å) | | 主引用文献 | Molecular architecture of a eukaryotic translational initiation complex.
Science, 342, 2013
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4V5M
 | | tRNA tranlocation on the 70S ribosome: the pre-translocational translocation intermediate TI(PRE) | | 分子名称: | 16S RRNA, 23S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, ... | | 著者 | Ratje, A.H, Loerke, J, Mikolajka, A, Bruenner, M, Hildebrand, P.W, Starosta, A.L, Doenhoefer, A, Connell, S.R, Fucini, P, Mielke, T, Whitford, P.C, Onuchic, J.N, Yu, Y, Sanbonmatsu, K.Y, Hartmann, R.K, Penczek, P.A, Wilson, D.N, Spahn, C.M.T. | | 登録日 | 2010-10-01 | | 公開日 | 2014-07-09 | | 最終更新日 | 2019-12-11 | | 実験手法 | ELECTRON MICROSCOPY (7.8 Å) | | 主引用文献 | Head Swivel on the Ribosome Facilitates Translocation by Means of Intra-Subunit tRNA Hybrid Sites.
Nature, 468, 2010
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4V9H
 | | Crystal structure of the ribosome bound to elongation factor G in the guanosine triphosphatase state | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Tourigny, D.S, Fernandez, I.S, Kelley, A.C, Ramakrishnan, V. | | 登録日 | 2013-03-25 | | 公開日 | 2014-07-09 | | 最終更新日 | 2014-12-10 | | 実験手法 | X-RAY DIFFRACTION (2.857 Å) | | 主引用文献 | Elongation factor G bound to the ribosome in an intermediate state of translocation.
Science, 340, 2013
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4V5R
 | | The crystal structure of EF-Tu and Trp-tRNA-Trp bound to a cognate codon on the 70S ribosome. | | 分子名称: | 16S RRNA, 23S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, ... | | 著者 | Schmeing, T.M, Voorhees, R.M, Ramakrishnan, V. | | 登録日 | 2010-12-07 | | 公開日 | 2014-07-09 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | How Mutations in tRNA Distant from the Anticodon Affect the Fidelity of Decoding.
Nat.Struct.Mol.Biol., 18, 2011
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2C77
 | | EF-Tu complexed with a GTP analog and the antibiotic GE2270 A | | 分子名称: | DI(HYDROXYETHYL)ETHER, ELONGATION FACTOR TU-B, MAGNESIUM ION, ... | | 著者 | Parmeggiani, A, Krab, I.M, Okamura, S, Nielsen, R.C, Nyborg, J, Nissen, P. | | 登録日 | 2005-11-18 | | 公開日 | 2006-03-16 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structural basis of the action of pulvomycin and GE2270 A on elongation factor Tu.
Biochemistry, 45, 2006
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7UVP
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2DCU
 | | Crystal structure of translation initiation factor aIF2betagamma heterodimer with GDP | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Translation initiation factor 2 beta subunit, ... | | 著者 | Sokabe, M, Yao, M, Sakai, N, Toya, S, Tanaka, I. | | 登録日 | 2006-01-16 | | 公開日 | 2006-07-25 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Structure of archaeal translational initiation factor 2 betagamma-GDP reveals significant conformational change of the beta-subunit and switch 1 region.
Proc.Natl.Acad.Sci.USA, 103, 2006
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2BVN
 | | E. coli EF-Tu:GDPNP in complex with the antibiotic enacyloxin IIa | | 分子名称: | ELONGATION FACTOR TU, ENACYLOXIN IIA, MAGNESIUM ION, ... | | 著者 | Parmeggiani, A, Krab, I.M, Watanabe, T, Nielsen, R.C, Dahlberg, C, Nyborg, J, Nissen, P. | | 登録日 | 2005-06-30 | | 公開日 | 2005-09-01 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Enacyloxin Iia Pinpoints a Binding Pocket of Elongation Factor TU for Development of Novel Antibiotics.
J.Biol.Chem., 281, 2006
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7UNV
 | | Pseudomonas aeruginosa 70S ribosome initiation complex bound to IF2-GDPCP (structure II-A) | | 分子名称: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Basu, R.S, Sherman, M.B, Gagnon, M.G. | | 登録日 | 2022-04-11 | | 公開日 | 2022-06-22 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Compact IF2 allows initiator tRNA accommodation into the P site and gates the ribosome to elongation
Nat Commun, 13, 2022
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7UNU
 | | Pseudomonas aeruginosa 70S ribosome initiation complex bound to compact IF2-GDP (composite structure I-B) | | 分子名称: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Basu, R.S, Sherman, M.B, Gagnon, M.G. | | 登録日 | 2022-04-11 | | 公開日 | 2022-06-22 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Compact IF2 allows initiator tRNA accommodation into the P site and gates the ribosome to elongation
Nat Commun, 13, 2022
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7UNR
 | | Pseudomonas aeruginosa 70S ribosome initiation complex bound to compact IF2-GDP (composite structure I-A) | | 分子名称: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Basu, R.S, Sherman, M.B, Gagnon, M.G. | | 登録日 | 2022-04-11 | | 公開日 | 2022-06-22 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Compact IF2 allows initiator tRNA accommodation into the P site and gates the ribosome to elongation
Nat Commun, 13, 2022
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7VMC
 | | Crystal structure of EF-Tu/CdiA/CdiI | | 分子名称: | Contact-dependent inhibitor I, Elongation factor Tu, tRNA nuclease CdiA | | 著者 | Wang, J, Yashiro, Y, Tomita, K. | | 登録日 | 2021-10-08 | | 公開日 | 2022-03-30 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3.413 Å) | | 主引用文献 | Mechanistic insights into tRNA cleavage by a contact-dependent growth inhibitor protein and translation factors.
Nucleic Acids Res., 50, 2022
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2B7B
 | | Yeast guanine nucleotide exchange factor eEF1Balpha K205A mutant in complex with eEF1A and GDP | | 分子名称: | Elongation factor 1-alpha, GUANOSINE-5'-DIPHOSPHATE, elongation factor-1 beta | | 著者 | Pittman, Y.R, Valente, L, Jeppesen, M.G, Andersen, G.R, Patel, S, Kinzy, T.G. | | 登録日 | 2005-10-04 | | 公開日 | 2006-05-02 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Mg2+ and a key lysine modulate exchange activity of eukaryotic translation elongation factor 1B alpha
J.Biol.Chem., 281, 2006
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2B7C
 | | Yeast guanine nucleotide exchange factor eEF1Balpha K205A mutant in complex with eEF1A | | 分子名称: | Elongation factor 1-alpha, elongation factor-1 beta | | 著者 | Pittman, Y.R, Valente, L, Jeppesen, M.G, Andersen, G.R, Patel, S, Kinzy, T.G. | | 登録日 | 2005-10-04 | | 公開日 | 2006-05-02 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Mg2+ and a key lysine modulate exchange activity of eukaryotic translation elongation factor 1B alpha
J.Biol.Chem., 281, 2006
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7UIU
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7UNQ
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7UNW
 | | Pseudomonas aeruginosa 70S ribosome initiation complex bound to IF2-GDPCP (structure II-B) | | 分子名称: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Basu, R.S, Sherman, M.B, Gagnon, M.G. | | 登録日 | 2022-04-11 | | 公開日 | 2022-06-22 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Compact IF2 allows initiator tRNA accommodation into the P site and gates the ribosome to elongation
Nat Commun, 13, 2022
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7UNT
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2AHO
 | | Structure of the archaeal initiation factor eIF2 alpha-gamma heterodimer from Sulfolobus solfataricus complexed with GDPNP | | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Translation initiation factor 2 alpha subunit, ... | | 著者 | Yatime, L, Mechulam, Y, Blanquet, S, Schmitt, E. | | 登録日 | 2005-07-28 | | 公開日 | 2006-01-31 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural Switch of the gamma Subunit in an Archaeal aIF2alphagamma Heterodimer
Structure, 14, 2006
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2EFG
 | | TRANSLATIONAL ELONGATION FACTOR G COMPLEXED WITH GDP | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, PROTEIN (ELONGATION FACTOR G DOMAIN 3), PROTEIN (ELONGATION FACTOR G) | | 著者 | Czworkowski, J, Wang, J, Steitz, T.A, Moore, P.B. | | 登録日 | 1998-09-23 | | 公開日 | 1999-09-30 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | The crystal structure of elongation factor G complexed with GDP, at 2.7 A resolution.
EMBO J., 13, 1994
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2E1R
 | | Structure of eEF2 in complex with a sordarin derivative | | 分子名称: | (1S,4S,5S,6R,9S,11S)-6-CHLORO-9-FORMYL-13-ISOPROPYL-5-METHYL-2-({[(3AR,5R,7R ,7AS)-7-METHYL-3-METHYLENEHEXAHYDRO-2H-FURO[2,3-C]PYRAN-5-YL]OXY}METHYL)TETR ACYCLO[7.4.0.02,11.04,8]TRIDEC-12-ENE-1-CARBOXYLIC ACI, Elongation factor 2, GUANOSINE-5'-DIPHOSPHATE | | 著者 | Soe, R, Mosley, R.T, Andersen, G.R. | | 登録日 | 2006-10-27 | | 公開日 | 2006-11-14 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | | 主引用文献 | Sordarin derivatives induce a novel conformation of the yeast ribosome translocation factor eEF2
J.Biol.Chem., 282, 2007
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2C78
 | | EF-Tu complexed with a GTP analog and the antibiotic pulvomycin | | 分子名称: | (1S,2S,3E,5E,7E,10S,11S,12S)-12-[(2R,4E,6E,8Z,10R,12E,14E,16Z,18S,19Z)-10,18-DIHYDROXY-12,16,19-TRIMETHYL-11,22-DIOXOOX ACYCLODOCOSA-4,6,8,12,14,16,19-HEPTAEN-2-YL]-2,11-DIHYDROXY-1,10-DIMETHYL-9-OXOTRIDECA-3,5,7-TRIEN-1-YL 6-DEOXY-2,4-DI-O-METHYL-BETA-L-GALACTOPYRANOSIDE, ELONGATION FACTOR TU-A, MAGNESIUM ION, ... | | 著者 | Parmeggiani, A, Krab, I.M, Okamura, S, Nielsen, R.C, Nyborg, J, Nissen, P. | | 登録日 | 2005-11-18 | | 公開日 | 2006-03-16 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Structural basis of the action of pulvomycin and GE2270 A on elongation factor Tu.
Biochemistry, 45, 2006
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2D74
 | | Crystal structure of translation initiation factor aIF2betagamma heterodimer | | 分子名称: | Translation initiation factor 2 beta subunit, Translation initiation factor 2 gamma subunit, ZINC ION | | 著者 | Sokabe, M, Yao, M, Sakai, N, Toya, S, Tanaka, I. | | 登録日 | 2005-11-16 | | 公開日 | 2006-07-25 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structure of archaeal translational initiation factor 2 betagamma-GDP reveals significant conformational change of the beta-subunit and switch 1 region.
Proc.Natl.Acad.Sci.USA, 103, 2006
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