2C78

EF-Tu complexed with a GTP analog and the antibiotic pulvomycin

Summary for 2C78

• Entry DOI: 10.2210/pdb2c78/pdb
• Related: 1HA3
• Descriptor: ELONGATION FACTOR TU-A, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: hydrolase, gtpase, translation elongation factor, protein synthesis, antibiotic, gtp-binding, nucleotide-binding, phosphorylation, protein biosynthesis, elongation factor
• Biological source: THERMUS THERMOPHILUS
• Total number of polymer chains: 1
• Total formula weight: 46067.36

Authors

Parmeggiani, A.,Krab, I.M.,Okamura, S.,Nielsen, R.C.,Nyborg, J.,Nissen, P. (deposition date: 2005-11-18, release date: 2006-03-16, Last modification date: 2023-12-13)

• Primary citation: Parmeggiani, A.,Krab, I.M.,Okamura, S.,Nielsen, R.C.,Nyborg, J.,Nissen, P.; Structural basis of the action of pulvomycin and GE2270 A on elongation factor Tu.; Biochemistry, 45:6846-6857, 2006; PubMed: 16734421; DOI: 10.1021/bi0525122

Experimental method

X-RAY DIFFRACTION (1.4 Å)