2C78
EF-Tu complexed with a GTP analog and the antibiotic pulvomycin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003746 | molecular_function | translation elongation factor activity |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006412 | biological_process | translation |
| A | 0006414 | biological_process | translational elongation |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A1407 |
| Chain | Residue |
| A | THR25 |
| A | THR62 |
| A | GNP1406 |
| A | HOH2010 |
| A | HOH2035 |
| site_id | AC2 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE GNP A1406 |
| Chain | Residue |
| A | LYS24 |
| A | THR25 |
| A | THR26 |
| A | TYR47 |
| A | ILE61 |
| A | THR62 |
| A | GLY84 |
| A | ASN136 |
| A | LYS137 |
| A | ASP139 |
| A | MET140 |
| A | SER174 |
| A | ALA175 |
| A | LEU176 |
| A | MG1407 |
| A | HOH2010 |
| A | HOH2035 |
| A | HOH2046 |
| A | HOH2113 |
| A | HOH2319 |
| A | HOH2320 |
| A | HOH2321 |
| A | HOH2322 |
| A | VAL20 |
| A | ASP21 |
| A | HIS22 |
| A | GLY23 |
| site_id | AC3 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE PUL A1408 |
| Chain | Residue |
| A | ILE89 |
| A | THR94 |
| A | ALA97 |
| A | GLN98 |
| A | GLU226 |
| A | PHE229 |
| A | GLY240 |
| A | GLU271 |
| A | MET272 |
| A | HIS273 |
| A | VAL286 |
| A | ARG300 |
| A | TYR343 |
| A | PHE344 |
| A | ARG345 |
| A | THR346 |
| A | ARG385 |
| A | ALA387 |
| A | ARG389 |
| A | HOH2324 |
| A | HOH2325 |
| A | HOH2326 |
| A | HOH2327 |
Functional Information from PROSITE/UniProt
| site_id | PS00301 |
| Number of Residues | 16 |
| Details | G_TR_1 Translational (tr)-type guanine nucleotide-binding (G) domain signature. DKapeERaRGITIntA |
| Chain | Residue | Details |
| A | ASP51-ALA66 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 205 |
| Details | Domain: {"description":"tr-type G"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 7 |
| Details | Region: {"description":"G1","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Region: {"description":"G2","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Region: {"description":"G3","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Region: {"description":"G4","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Region: {"description":"G5","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11278992","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HA3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C78","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4V5G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4V5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4V5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4V5R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4V5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4V8Q","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00118","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"2C78","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P0CE47","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| A | ASP21 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| A | HIS85 |
