2E1R

Structure of eEF2 in complex with a sordarin derivative

Summary for 2E1R

Entry DOI	10.2210/pdb2e1r/pdb
Related	1n0u 2npf
Descriptor	Elongation factor 2, (1S,4S,5S,6R,9S,11S)-6-CHLORO-9-FORMYL-13-ISOPROPYL-5-METHYL-2-({[(3AR,5R,7R ,7AS)-7-METHYL-3-METHYLENEHEXAHYDRO-2H-FURO[2,3-C]PYRAN-5-YL]OXY}METHYL)TETR ACYCLO[7.4.0.02,11.04,8]TRIDEC-12-ENE-1-CARBOXYLIC ACI, GUANOSINE-5'-DIPHOSPHATE (3 entities in total)
Functional Keywords	protein-ligand complex, g-protein, translation
Biological source	Saccharomyces cerevisiae (baker's yeast)
Cellular location	Cytoplasm : P32324
Total number of polymer chains	1
Total formula weight	94369.40
Authors	Soe, R.,Mosley, R.T.,Andersen, G.R. (deposition date: 2006-10-27, release date: 2006-11-14, Last modification date: 2023-10-25)
Primary citation	Soe, R.,Mosley, R.T.,Justice, M.,Nielsen-Kahn, J.,Shastry, M.,Merrill, A.R.,Andersen, G.R. Sordarin derivatives induce a novel conformation of the yeast ribosome translocation factor eEF2 J.Biol.Chem., 282:657-666, 2007 Cited by PubMed: 17082187 DOI: 10.1074/jbc.M607830200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.15 Å)

Structure validation