2NPF

Structure of eEF2 in complex with moriniafungin

Summary for 2NPF

Entry DOI	10.2210/pdb2npf/pdb
Related	1n0u 2E1R
Descriptor	Elongation factor 2, (1S,4R,5R,9S,11S)-2-({[(2S,5R,6R,7R,9S,10R)-2-(7-CARBOXYHEPTYL)-6-HYDROXY-10-METHOXY-9-METHYL-3-OXO-1,4,8-TRIOXASPIRO[4 .5]DEC-7-YL]OXY}METHYL)-9-FORMYL-13-ISOPROPYL-5-METHYLTETRACYCLO[7.4.0.02,11.04.8]TRIDEC-12-ENE-1-CARBOXYLIC ACID, GUANOSINE-5'-DIPHOSPHATE (3 entities in total)
Functional Keywords	protein-inhibitor complex, g-protein, translation
Biological source	Saccharomyces cerevisiae (baker's yeast)
Cellular location	Cytoplasm : P32324
Total number of polymer chains	2
Total formula weight	189082.29
Authors	Soe, R.,Mosley, R.T.,Andersen, G.R. (deposition date: 2006-10-27, release date: 2006-11-14, Last modification date: 2023-10-25)
Primary citation	Soe, R.,Mosley, R.T.,Justice, M.,Nielsen-Kahn, J.,Shastry, M.,Merrill, A.R.,Andersen, G.R. Sordarin derivatives induce a novel conformation of the yeast ribosome translocation factor eEF2 J.Biol.Chem., 282:657-666, 2007 Cited by PubMed: 17082187 DOI: 10.1074/jbc.M607830200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation