7NNU
| Cryo-EM structure of the folate-specific ECF transporter complex in MSP2N2 lipid nanodiscs | Descriptor: | Conserved hypothetical membrane protein, Energy-coupling factor transporter ATP-binding protein EcfA1, Energy-coupling factor transporter ATP-binding protein EcfA2, ... | Authors: | Thangaratnarajah, C, Rheinberger, J, Paulino, C, Slotboom, D.J. | Deposit date: | 2021-02-25 | Release date: | 2021-08-18 | Last modified: | 2021-09-22 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Insights into the bilayer-mediated toppling mechanism of a folate-specific ECF transporter by cryo-EM. Proc.Natl.Acad.Sci.USA, 118, 2021
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7NIW
| Nanodisc reconstituted human ABCB4 in complex with 4B1-Fab (posaconazole-bound, inward-open conformation) | Descriptor: | 1,2-DILINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 4B1 Fab-fragment heavy chain, 4B1 Fab-fragment light chain, ... | Authors: | Nosol, K, Locher, K.P. | Deposit date: | 2021-02-14 | Release date: | 2021-08-25 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structures of ABCB4 provide insight into phosphatidylcholine translocation. Proc.Natl.Acad.Sci.USA, 118, 2021
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7NIV
| Nanodisc reconstituted human ABCB4 in complex with 4B1-Fab and QA2-Fab (phosphatidylcholine-bound, occluded conformation) | Descriptor: | 1,2-DILINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 4B1 Fab-fragment light chain, CHOLESTEROL, ... | Authors: | Nosol, K, Locher, K.P. | Deposit date: | 2021-02-14 | Release date: | 2021-08-25 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structures of ABCB4 provide insight into phosphatidylcholine translocation. Proc.Natl.Acad.Sci.USA, 118, 2021
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7NIU
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7N59
| Structure of AtAtm3 in the inward-facing conformation with GSSG bound | Descriptor: | ABC transporter B family member 25, mitochondrial, OXIDIZED GLUTATHIONE DISULFIDE | Authors: | Fan, C, Rees, D.C. | Deposit date: | 2021-06-05 | Release date: | 2022-04-13 | Last modified: | 2022-04-20 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Glutathione binding to the plant At Atm3 transporter and implications for the conformational coupling of ABC transporters. Elife, 11, 2022
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7N58
| Structure of AtAtm3 in the inward-facing conformation | Descriptor: | ABC transporter B family member 25, mitochondrial | Authors: | Fan, C, Rees, D.C. | Deposit date: | 2021-06-05 | Release date: | 2022-04-13 | Last modified: | 2022-04-20 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Glutathione binding to the plant At Atm3 transporter and implications for the conformational coupling of ABC transporters. Elife, 11, 2022
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7N5A
| Structure of AtAtm3 in the closed conformation | Descriptor: | ABC transporter B family member 25, mitochondrial, ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | Fan, C, Rees, D.C. | Deposit date: | 2021-06-05 | Release date: | 2022-04-13 | Last modified: | 2022-04-20 | Method: | ELECTRON MICROSCOPY (3.95 Å) | Cite: | Glutathione binding to the plant At Atm3 transporter and implications for the conformational coupling of ABC transporters. Elife, 11, 2022
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7N5B
| Structure of AtAtm3 in the outward-facing conformation | Descriptor: | ABC transporter B family member 25, mitochondrial, ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | Fan, C, Rees, D.C. | Deposit date: | 2021-06-05 | Release date: | 2022-04-13 | Last modified: | 2022-04-20 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Glutathione binding to the plant At Atm3 transporter and implications for the conformational coupling of ABC transporters. Elife, 11, 2022
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7O80
| Rabbit 80S ribosome in complex with eRF1 and ABCE1 stalled at the STOP codon in the mutated SARS-CoV-2 slippery site | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ... | Authors: | Bhatt, P.R, Scaiola, A, Leibundgut, M.A, Atkins, J.F, Ban, N. | Deposit date: | 2021-04-14 | Release date: | 2021-06-02 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome. Science, 372, 2021
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7OJ8
| ABCG2 E1S turnover-2 state | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Broad substrate specificity ATP-binding cassette transporter ABCG2, CHOLESTEROL, ... | Authors: | Ni, D, Yu, Q, Kowal, J, Manolaridis, I, Jackson, S.M, Stahlberg, H, Locher, K.P. | Deposit date: | 2021-05-14 | Release date: | 2021-07-21 | Last modified: | 2021-07-28 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism. Nat Commun, 12, 2021
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7OJH
| ABCG2 topotecan turnover-1 state | Descriptor: | (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, ADENOSINE-5'-TRIPHOSPHATE, Broad substrate specificity ATP-binding cassette transporter ABCG2, ... | Authors: | Yu, Q, Ni, D, Kowal, J, Manolaridis, I, Jackson, S.M, Stahlberg, H, Locher, K.P. | Deposit date: | 2021-05-15 | Release date: | 2021-07-21 | Last modified: | 2021-07-28 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism. Nat Commun, 12, 2021
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7OJI
| ABCG2 topotecan turnover-2 state | Descriptor: | (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, ADENOSINE-5'-TRIPHOSPHATE, Broad substrate specificity ATP-binding cassette transporter ABCG2, ... | Authors: | Yu, Q, Ni, D, Kowal, J, Manolaridis, I, Jackson, S.M, Stahlberg, H, Locher, K.P. | Deposit date: | 2021-05-16 | Release date: | 2021-07-21 | Last modified: | 2021-07-28 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism. Nat Commun, 12, 2021
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7O9W
| Encequidar-bound human P-glycoprotein in complex with UIC2-Fab | Descriptor: | Multidrug resistance protein 1, UIC2 Fab-fragment heavy chain, UIC2 Fab-fragment light chain, ... | Authors: | Nosol, K, Locher, K.P. | Deposit date: | 2021-04-17 | Release date: | 2022-01-12 | Last modified: | 2022-01-26 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Discovery and Characterization of Potent Dual P-Glycoprotein and CYP3A4 Inhibitors: Design, Synthesis, Cryo-EM Analysis, and Biological Evaluations. J.Med.Chem., 65, 2022
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7O11
| ABC transporter NosDFY, nucleotide-free in GDN, R-domain 1 | Descriptor: | MAGNESIUM ION, Probable ABC transporter ATP-binding protein NosF, Probable ABC transporter binding protein NosD, ... | Authors: | Mueller, C, Zhang, L, Lu, W, Einsle, O, Du, J. | Deposit date: | 2021-03-28 | Release date: | 2022-04-13 | Last modified: | 2022-10-26 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Molecular interplay of an assembly machinery for nitrous oxide reductase. Nature, 608, 2022
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7O14
| ABC transporter NosDFY, nucleotide-free in lipid nanodisc, R-domain 1 | Descriptor: | MAGNESIUM ION, Probable ABC transporter ATP-binding protein NosF, Probable ABC transporter binding protein NosD, ... | Authors: | Mueller, C, Zhang, L, Lu, W, Einsle, O, Du, J. | Deposit date: | 2021-03-28 | Release date: | 2022-04-13 | Last modified: | 2022-10-26 | Method: | ELECTRON MICROSCOPY | Cite: | Molecular interplay of an assembly machinery for nitrous oxide reductase. Nature, 608, 2022
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7O17
| ABC transporter NosDFY E154Q, ATP-bound in lipid nanodisc | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Probable ABC transporter ATP-binding protein NosF, ... | Authors: | Mueller, C, Zhang, L, Lu, W, Einsle, O, Du, J. | Deposit date: | 2021-03-28 | Release date: | 2022-04-13 | Last modified: | 2022-10-26 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Molecular interplay of an assembly machinery for nitrous oxide reductase. Nature, 608, 2022
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7O10
| ABC transporter NosDFY, nucleotide-free in GDN, R-domain 2 | Descriptor: | MAGNESIUM ION, Probable ABC transporter ATP-binding protein NosF, Probable ABC transporter binding protein NosD, ... | Authors: | Mueller, C, Zhang, L, Lu, W, Einsle, O, Du, J. | Deposit date: | 2021-03-28 | Release date: | 2022-04-13 | Last modified: | 2022-10-26 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Molecular interplay of an assembly machinery for nitrous oxide reductase. Nature, 608, 2022
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7O15
| ABC transporter NosDFY, nucleotide-free in lipid nanodisc, R-domain 2 | Descriptor: | MAGNESIUM ION, Probable ABC transporter ATP-binding protein NosF, Probable ABC transporter binding protein NosD, ... | Authors: | Mueller, C, Zhang, L, Lu, W, Einsle, O, Du, J. | Deposit date: | 2021-03-28 | Release date: | 2022-04-13 | Last modified: | 2022-10-26 | Method: | ELECTRON MICROSCOPY | Cite: | Molecular interplay of an assembly machinery for nitrous oxide reductase. Nature, 608, 2022
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7O0Y
| ABC transporter NosDFY, nucleotide-free in GDN | Descriptor: | MAGNESIUM ION, Probable ABC transporter ATP-binding protein NosF, Probable ABC transporter binding protein NosD, ... | Authors: | Mueller, C, Zhang, L, Lu, W, Einsle, O, Du, J. | Deposit date: | 2021-03-28 | Release date: | 2022-04-13 | Last modified: | 2022-10-26 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Molecular interplay of an assembly machinery for nitrous oxide reductase. Nature, 608, 2022
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7O16
| ABC transporter NosDFY, nucleotide-free in lipid nanodisc, R-domain 3 | Descriptor: | MAGNESIUM ION, Probable ABC transporter ATP-binding protein NosF, Probable ABC transporter binding protein NosD, ... | Authors: | Mueller, C, Zhang, L, Lu, W, Einsle, O, Du, J. | Deposit date: | 2021-03-28 | Release date: | 2022-04-13 | Last modified: | 2022-10-26 | Method: | ELECTRON MICROSCOPY | Cite: | Molecular interplay of an assembly machinery for nitrous oxide reductase. Nature, 608, 2022
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7O12
| ABC transporter NosDFY, AMPPNP-bound in GDN | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Probable ABC transporter ATP-binding protein NosF, ... | Authors: | Mueller, C, Zhang, L, Lu, W, Einsle, O, Du, J. | Deposit date: | 2021-03-28 | Release date: | 2022-04-13 | Last modified: | 2022-10-26 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Molecular interplay of an assembly machinery for nitrous oxide reductase. Nature, 608, 2022
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7OCY
| Enterococcus faecalis EfrCD in complex with a nanobody | Descriptor: | ABC transporter ATP-binding protein, Nanobody | Authors: | Ehrenbolger, K, Hutter, C.A.J, Meier, G, Seeger, M.A, Barandun, J. | Deposit date: | 2021-04-28 | Release date: | 2022-05-18 | Last modified: | 2023-05-31 | Method: | ELECTRON MICROSCOPY (4.25 Å) | Cite: | Deep mutational scan of a drug efflux pump reveals its structure-function landscape. Nat.Chem.Biol., 19, 2023
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7O13
| ABC transporter NosDFY, nucleotide-free in lipid nanodisc | Descriptor: | MAGNESIUM ION, Probable ABC transporter ATP-binding protein NosF, Probable ABC transporter binding protein NosD, ... | Authors: | Mueller, C, Zhang, L, Lu, W, Einsle, O, Du, J. | Deposit date: | 2021-03-28 | Release date: | 2022-11-02 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Molecular interplay of an assembly machinery for nitrous oxide reductase. Nature, 608, 2022
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7O0Z
| ABC transporter NosFY, nucleotide-free in GDN | Descriptor: | Probable ABC transporter ATP-binding protein NosF, Probable ABC transporter permease protein NosY | Authors: | Mueller, C, Zhang, L, Lu, W, Einsle, O, Du, J. | Deposit date: | 2021-03-28 | Release date: | 2022-11-02 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Molecular interplay of an assembly machinery for nitrous oxide reductase. Nature, 608, 2022
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7OZ1
| Cryo-EM structure of ABCG1 E242Q mutant with ATP and cholesteryl hemisuccinate bound | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Skarda, L, Kowal, J, Locher, K.P. | Deposit date: | 2021-06-25 | Release date: | 2021-09-22 | Last modified: | 2021-09-29 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structure of the Human Cholesterol Transporter ABCG1. J.Mol.Biol., 433, 2021
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