PDB: 267 件ウェブページステータス検索Chemie searchBIRD

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7UNE	The V1 region of bovine V-ATPase in complex with human mEAK7 (focused refinement) 分子名称: KIAA1609 protein, isoform CRA_a, V-type proton ATPase catalytic subunit A, ... 著者 Wang, R, Li, X. 登録日 2022-04-10 公開日 2022-06-15 最終更新日 2024-02-14 実験手法 ELECTRON MICROSCOPY (3.73 Å) 主引用文献 Molecular basis of mEAK7-mediated human V-ATPase regulation. Nat Commun, 13, 2022
7N8B	Cycloheximide bound vacant 80S structure isolated from cbf5-D95A 分子名称: 18S RIBOSOMAL RNA, 25S, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ... 著者 Rai, J, Zhao, Y, Li, H. 登録日 2021-06-14 公開日 2022-05-11 最終更新日 2022-07-20 実験手法 ELECTRON MICROSCOPY (3.05 Å) 主引用文献 CryoEM structures of pseudouridine-free ribosome suggest impacts of chemical modifications on ribosome conformations. Structure, 30, 2022
7T3B	GATOR1-RAG-RAGULATOR - GAP Complex 分子名称: ALUMINUM FLUORIDE, GATOR complex protein DEPDC5, GATOR complex protein NPRL2, ... 著者 Egri, S.B, Shen, K. 登録日 2021-12-07 公開日 2022-04-06 最終更新日 2022-06-01 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism. Mol.Cell, 82, 2022
7T3A	GATOR1-RAG-RAGULATOR - Inhibitory Complex 分子名称: GATOR complex protein DEPDC5, GATOR complex protein NPRL2, GATOR complex protein NPRL3, ... 著者 Egri, S.B, Shen, K. 登録日 2021-12-07 公開日 2022-04-06 最終更新日 2022-06-01 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism. Mol.Cell, 82, 2022
7T3C	GATOR1-RAG-RAGULATOR - Dual Complex 分子名称: ALUMINUM FLUORIDE, GATOR complex protein DEPDC5, GATOR complex protein NPRL2, ... 著者 Egri, S.B, Shen, K. 登録日 2021-12-07 公開日 2022-04-06 最終更新日 2022-06-01 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism. Mol.Cell, 82, 2022
7DKL	Crystal structure of the tandem DEP domains of DEPTOR 分子名称: DEP domain-containing mTOR-interacting protein 著者 Weng, Z.F, Shen, X.X, Liu, Y.F. 登録日 2020-11-24 公開日 2021-12-08 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structural Basis of DEPTOR to Recognize Phosphatidic Acid Using its Tandem DEP Domains. J.Mol.Biol., 433, 2021
7LSW	Structure of Full Beta-Hairpin LIR from FNIP2 Bound to GABARAP 分子名称: Folliculin-interacting protein 2,Gamma-aminobutyric acid receptor-associated protein, SULFATE ION 著者 Appleton, B.A. 登録日 2021-02-18 公開日 2021-10-13 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.05 Å) 主引用文献 GABARAP sequesters the FLCN-FNIP tumor suppressor complex to couple autophagy with lysosomal biogenesis. Sci Adv, 7, 2021
7LT6	Structure of Partial Beta-Hairpin LIR from FNIP2 Bound to GABARAP 分子名称: Folliculin-interacting protein 2,Gamma-aminobutyric acid receptor-associated protein 著者 Appleton, B.A. 登録日 2021-02-18 公開日 2021-10-13 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 GABARAP sequesters the FLCN-FNIP tumor suppressor complex to couple autophagy with lysosomal biogenesis. Sci Adv, 7, 2021
7PE7	cryo-EM structure of DEPTOR bound to human mTOR complex 2, overall refinement 分子名称: ACETYL GROUP, DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, ... 著者 Waelchli, M, Maier, T. 登録日 2021-08-09 公開日 2021-09-15 最終更新日 2021-09-29 実験手法 ELECTRON MICROSCOPY (3.41 Å) 主引用文献 Regulation of human mTOR complexes by DEPTOR. Elife, 10, 2021
7PED	DEPTOR DEP domain tandem (DEPt) 分子名称: DEP domain-containing mTOR-interacting protein 著者 Waelchli, M, Jakob, R, Maier, T. 登録日 2021-08-09 公開日 2021-09-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Regulation of human mTOR complexes by DEPTOR. Elife, 10, 2021
7OWG	human DEPTOR in a complex with mutant human mTORC1 A1459P 分子名称: DEP domain-containing mTOR-interacting protein, Regulatory-associated protein of mTOR, Serine/threonine-protein kinase mTOR, ... 著者 Heimhalt, M, Berndt, A, Wagstaff, J, Anandapadamanaban, M, Perisic, O, Maslen, S, McLaughlin, S, Yu, W.-H, Masson, G.R, Boland, A, Ni, X, Yamashita, K, Murshudov, G.N, Skehel, M, Freund, S.M, Williams, R.L. 登録日 2021-06-18 公開日 2021-09-08 最終更新日 2022-02-23 実験手法 ELECTRON MICROSCOPY (4.7 Å) 主引用文献 Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace. Elife, 10, 2021
7PE8	cryo-EM structure of DEPTOR bound to human mTOR complex 2, focussed on one protomer 分子名称: ACETYL GROUP, DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, ... 著者 Waelchli, M, Maier, T. 登録日 2021-08-09 公開日 2021-09-08 最終更新日 2021-09-29 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Regulation of human mTOR complexes by DEPTOR. Elife, 10, 2021
7PEA	cryo-EM structure of DEPTOR bound to human mTOR complex 1, overall refinement 分子名称: DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, Regulatory-associated protein of mTOR, ... 著者 Waelchli, M, Maier, T. 登録日 2021-08-09 公開日 2021-09-08 最終更新日 2021-09-29 実験手法 ELECTRON MICROSCOPY (4.07 Å) 主引用文献 Regulation of human mTOR complexes by DEPTOR. Elife, 10, 2021
7PEC	cryo-EM structure of DEPTOR bound to human mTOR complex 1, DEPt-bound subset local refinement 分子名称: DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, Regulatory-associated protein of mTOR, ... 著者 Waelchli, M, Maier, T. 登録日 2021-08-09 公開日 2021-09-08 最終更新日 2021-09-29 実験手法 ELECTRON MICROSCOPY (4.24 Å) 主引用文献 Regulation of human mTOR complexes by DEPTOR. Elife, 10, 2021
7PEB	cryo-EM structure of DEPTOR bound to human mTOR complex 1, focussed on one protomer 分子名称: DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, Regulatory-associated protein of mTOR, ... 著者 Waelchli, M, Maier, T. 登録日 2021-08-09 公開日 2021-09-08 最終更新日 2021-09-29 実験手法 ELECTRON MICROSCOPY (3.67 Å) 主引用文献 Regulation of human mTOR complexes by DEPTOR. Elife, 10, 2021
7PE9	cryo-EM structure of DEPTOR bound to human mTOR complex 2, DEPt-bound subset local refinement 分子名称: ACETYL GROUP, DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, ... 著者 Waelchli, M, Maier, T. 登録日 2021-08-09 公開日 2021-09-08 最終更新日 2021-09-29 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Regulation of human mTOR complexes by DEPTOR. Elife, 10, 2021
7OLE	Cryo-EM structure of the TELO2-TTI1-TTI2-RUVBL1-RUVBL2 complex 分子名称: ADENOSINE-5'-DIPHOSPHATE, RuvB-like 1, RuvB-like 2, ... 著者 Pal, M, Llorca, O, Pearl, L. 登録日 2021-05-19 公開日 2021-07-07 最終更新日 2021-10-06 実験手法 ELECTRON MICROSCOPY (3.41 Å) 主引用文献 Structure of the TELO2-TTI1-TTI2 complex and its function in TOR recruitment to the R2TP chaperone. Cell Rep, 36, 2021
6ZPN	Crystal structure of Chaetomium thermophilum Raptor 分子名称: WD_REPEATS_REGION domain-containing protein 著者 Imseng, S, Boehm, R, Jakob, R.P, Hall, M.N, Hiller, S, Maier, T. 登録日 2020-07-08 公開日 2021-05-19 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 The dynamic mechanism of 4E-BP1 recognition and phosphorylation by mTORC1. Mol.Cell, 81, 2021
7JWE	Gedatolisib bound to the PI3Kg catalytic subunit p110 gamma 分子名称: Gedatolisib, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 著者 Burke, J.E, Rathinaswamy, M.K, Harris, N.J. 登録日 2020-08-25 公開日 2021-03-17 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Disease related mutations in PI3K gamma disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors. Elife, 10, 2021
7K6O	Crystal structure of PI3Kalpha inhibitor 10-5429 分子名称: (3S)-3-[4-(2-aminopyrimidin-5-yl)-2-(morpholin-4-yl)-5,6-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-N-methylpyrrolidine-1-sulfonamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 著者 Chen, P, Brooun, A, Deng, Y.L, Grodsky, N, Kaiser, S.E. 登録日 2020-09-21 公開日 2021-01-06 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.738 Å) 主引用文献 Structure-Based Drug Design and Synthesis of PI3K alpha-Selective Inhibitor (PF-06843195). J.Med.Chem., 64, 2021
7K71	Crystal structure of PI3Kalpha inhibitor 4-0686 分子名称: 2-(morpholin-4-yl)[4,5'-bipyrimidin]-2'-amine, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 著者 Chen, P, Brooun, A, Deng, Y.L, Grodsky, N, Kaiser, S.E. 登録日 2020-09-21 公開日 2021-01-06 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structure-Based Drug Design and Synthesis of PI3K alpha-Selective Inhibitor (PF-06843195). J.Med.Chem., 64, 2021
7K6N	Crystal structure of PI3Kalpha selective Inhibitor 11-1575 分子名称: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, tert-butyl (3S)-3-[4-(2-aminopyrimidin-5-yl)-2-(morpholin-4-yl)-5,6-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-3-methylpyrrolidine-1-carboxylate 著者 Chen, P, Brooun, A, Deng, Y.L, Grodsky, N, Kaiser, S.E. 登録日 2020-09-21 公開日 2021-01-06 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.77 Å) 主引用文献 Structure-Based Drug Design and Synthesis of PI3K alpha-Selective Inhibitor (PF-06843195). J.Med.Chem., 64, 2021
7K6M	Crystal structure of PI3Kalpha selective Inhibitor PF-06843195 分子名称: 2,2-difluoroethyl (3S)-3-{[2'-amino-5-fluoro-2-(morpholin-4-yl)[4,5'-bipyrimidin]-6-yl]amino}-3-(hydroxymethyl)pyrrolidine-1-carboxylate, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 著者 Chen, P, Brooun, A, Deng, Y.L, Grodsky, N, Kaiser, S.E. 登録日 2020-09-21 公開日 2021-01-06 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.413 Å) 主引用文献 Structure-Based Drug Design and Synthesis of PI3K alpha-Selective Inhibitor (PF-06843195). J.Med.Chem., 64, 2021
6XK9	Cereblon in complex with DDB1, CC-90009, and GSPT1 分子名称: 2-(4-chlorophenyl)-N-({2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-5-yl}methyl)-2,2-difluoroacetamide, DNA damage-binding protein 1, Eukaryotic peptide chain release factor GTP-binding subunit ERF3A, ... 著者 Clayton, T.L, Tran, E.T, Zhu, J, Pagarigan, B.E, Matyskiela, M.E, Chamberlain, P.P. 登録日 2020-06-25 公開日 2020-12-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.64 Å) 主引用文献 CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells. Blood, 137, 2021
6ZWO	cryo-EM structure of human mTOR complex 2, focused on one half 分子名称: ACETYL GROUP, INOSITOL HEXAKISPHOSPHATE, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... 著者 Scaiola, A, Mangia, F, Imseng, S, Boehringer, D, Ban, N, Maier, T. 登録日 2020-07-28 公開日 2020-11-18 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 The 3.2- angstrom resolution structure of human mTORC2. Sci Adv, 6, 2020

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