7K71
Crystal structure of PI3Kalpha inhibitor 4-0686
Summary for 7K71
Entry DOI | 10.2210/pdb7k71/pdb |
Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, 2-(morpholin-4-yl)[4,5'-bipyrimidin]-2'-amine (2 entities in total) |
Functional Keywords | kinase, signaling protein, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 110241.37 |
Authors | Chen, P.,Brooun, A.,Deng, Y.L.,Grodsky, N.,Kaiser, S.E. (deposition date: 2020-09-21, release date: 2021-01-06, Last modification date: 2024-04-03) |
Primary citation | Cheng, H.,Orr, S.T.M.,Bailey, S.,Brooun, A.,Chen, P.,Deal, J.G.,Deng, Y.L.,Edwards, M.P.,Gallego, G.M.,Grodsky, N.,Huang, B.,Jalaie, M.,Kaiser, S.,Kania, R.S.,Kephart, S.E.,Lafontaine, J.,Ornelas, M.A.,Pairish, M.,Planken, S.,Shen, H.,Sutton, S.,Zehnder, L.,Almaden, C.D.,Bagrodia, S.,Falk, M.D.,Gukasyan, H.J.,Ho, C.,Kang, X.,Kosa, R.E.,Liu, L.,Spilker, M.E.,Timofeevski, S.,Visswanathan, R.,Wang, Z.,Meng, F.,Ren, S.,Shao, L.,Xu, F.,Kath, J.C. Structure-Based Drug Design and Synthesis of PI3K alpha-Selective Inhibitor (PF-06843195). J.Med.Chem., 64:644-661, 2021 Cited by PubMed: 33356246DOI: 10.1021/acs.jmedchem.0c01652 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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