PDB: 266 件ウェブページステータス検索Chemie searchBIRD

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6ZPN	Crystal structure of Chaetomium thermophilum Raptor 分子名称: WD_REPEATS_REGION domain-containing protein 著者 Imseng, S, Boehm, R, Jakob, R.P, Hall, M.N, Hiller, S, Maier, T. 登録日 2020-07-08 公開日 2021-05-19 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 The dynamic mechanism of 4E-BP1 recognition and phosphorylation by mTORC1. Mol.Cell, 81, 2021
3LQ9	Crystal structure of human REDD1, a hypoxia-induced regulator of mTOR 分子名称: DNA-damage-inducible transcript 4 protein 著者 Vega-Rubin-de-Celis, S, Abdallah, Z, Brugarolas, J, Zhang, X. 登録日 2010-02-08 公開日 2010-03-09 最終更新日 2017-11-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural analysis and functional implications of the negative mTORC1 regulator REDD1. Biochemistry, 49, 2010
5GT8	Crystal Structure of apo-CASTOR1 分子名称: GATS-like protein 3 著者 Guo, L, Deng, D. 登録日 2016-08-18 公開日 2017-08-23 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structures of arginine sensor CASTOR1 in arginine-bound and ligand free states Biochem. Biophys. Res. Commun., 508, 2019
5GT7	Crystal Structure of Arg-bound CASTOR1 分子名称: ARGININE, GATS-like protein 3, MALONATE ION 著者 Guo, L, Deng, D. 登録日 2016-08-18 公開日 2017-08-23 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.048 Å) 主引用文献 Crystal structures of arginine sensor CASTOR1 in arginine-bound and ligand free states Biochem. Biophys. Res. Commun., 508, 2019
7N91	P70 S6K1 IN COMPLEX WITH MSC2317067A-1 分子名称: 4-{[(1S)-1-(3-fluorophenyl)-2-(methylamino)ethyl]amino}quinazoline-8-carboxamide, Ribosomal protein S6 kinase beta-1 著者 Mochalkin, I. 登録日 2021-06-16 公開日 2022-07-06 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Identification of Clinical Candidate M2698, a Dual p70S6K and Akt Inhibitor, for Treatment of PAM Pathway-Altered Cancers. J.Med.Chem., 64, 2021
7N93	P70 S6K1 IN COMPLEX WITH MSC2363318A-1 分子名称: 4-({(1S)-2-(azetidin-1-yl)-1-[4-chloro-3-(trifluoromethyl)phenyl]ethyl}amino)quinazoline-8-carboxamide, Ribosomal protein S6 kinase beta-1 著者 Mochalkin, I. 登録日 2021-06-16 公開日 2022-07-06 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.74 Å) 主引用文献 Identification of Clinical Candidate M2698, a Dual p70S6K and Akt Inhibitor, for Treatment of PAM Pathway-Altered Cancers. J.Med.Chem., 64, 2021
7UNE	The V1 region of bovine V-ATPase in complex with human mEAK7 (focused refinement) 分子名称: KIAA1609 protein, isoform CRA_a, V-type proton ATPase catalytic subunit A, ... 著者 Wang, R, Li, X. 登録日 2022-04-10 公開日 2022-06-15 最終更新日 2024-02-14 実験手法 ELECTRON MICROSCOPY (3.73 Å) 主引用文献 Molecular basis of mEAK7-mediated human V-ATPase regulation. Nat Commun, 13, 2022
7UNF	CryoEM structure of a mEAK7 bound human V-ATPase complex 分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-DIPHOSPHATE, ... 著者 Wang, R, Li, X. 登録日 2022-04-10 公開日 2022-06-15 最終更新日 2022-06-29 実験手法 ELECTRON MICROSCOPY (4.08 Å) 主引用文献 Molecular basis of mEAK7-mediated human V-ATPase regulation. Nat Commun, 13, 2022
6ULG	Cryo-EM structure of the FLCN-FNIP2-Rag-Ragulator complex 分子名称: Folliculin, Folliculin-interacting protein 2, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Shen, K, Rogala, K.B, Yu, Z.H, Sabatini, D.M. 登録日 2019-10-08 公開日 2019-11-20 最終更新日 2019-12-11 実験手法 ELECTRON MICROSCOPY (3.31 Å) 主引用文献 Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex. Cell, 179, 2019
3IBE	Crystal Structure of a Pyrazolopyrimidine Inhibitor Bound to PI3 Kinase Gamma 分子名称: 1-(4-{4-morpholin-4-yl-1-[1-(pyridin-3-ylcarbonyl)piperidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}phenyl)-3-pyridin-4-ylurea, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION 著者 Bard, J, Svenson, K. 登録日 2009-07-15 公開日 2009-09-01 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.798 Å) 主引用文献 ATP-Competitive Inhibitors of the Mammalian Target of Rapamycin: Design and Synthesis of Highly Potent and Selective Pyrazolopyrimidines. J.Med.Chem., 52, 2009
6WJ3	CryoEM structure of the SLC38A9-RagA-RagC-Ragulator complex in the post-GAP state 分子名称: GUANOSINE-5'-DIPHOSPHATE, Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, ... 著者 Fromm, S.A, Hurley, J.H. 登録日 2020-04-11 公開日 2020-09-02 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9. Nat.Struct.Mol.Biol., 27, 2020
6WJ2	CryoEM structure of the SLC38A9-RagA-RagC-Ragulator complex in the pre-GAP state 分子名称: 9-{5-O-[(S)-hydroxy{[(R)-hydroxy(thiophosphonooxy)phosphoryl]oxy}phosphoryl]-alpha-L-arabinofuranosyl}-3,9-dihydro-1H-purine-2,6-dione, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Fromm, S.A, Hurley, J.H. 登録日 2020-04-11 公開日 2020-09-02 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9. Nat.Struct.Mol.Biol., 27, 2020
6NZD	Cryo-EM Structure of the Lysosomal Folliculin Complex (FLCN-FNIP2-RagA-RagC-Ragulator) 分子名称: 9-{5-O-[(S)-hydroxy{[(R)-hydroxy(thiophosphonooxy)phosphoryl]oxy}phosphoryl]-alpha-L-arabinofuranosyl}-3,9-dihydro-1H-purine-2,6-dione, Folliculin, Folliculin-interacting protein 2, ... 著者 Fromm, S.A, Young, L.N, Hurley, J.H. 登録日 2019-02-13 公開日 2019-11-06 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex. Science, 366, 2019
7T3B	GATOR1-RAG-RAGULATOR - GAP Complex 分子名称: ALUMINUM FLUORIDE, GATOR complex protein DEPDC5, GATOR complex protein NPRL2, ... 著者 Egri, S.B, Shen, K. 登録日 2021-12-07 公開日 2022-04-06 最終更新日 2022-06-01 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism. Mol.Cell, 82, 2022
7T3C	GATOR1-RAG-RAGULATOR - Dual Complex 分子名称: ALUMINUM FLUORIDE, GATOR complex protein DEPDC5, GATOR complex protein NPRL2, ... 著者 Egri, S.B, Shen, K. 登録日 2021-12-07 公開日 2022-04-06 最終更新日 2022-06-01 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism. Mol.Cell, 82, 2022
7T3A	GATOR1-RAG-RAGULATOR - Inhibitory Complex 分子名称: GATOR complex protein DEPDC5, GATOR complex protein NPRL2, GATOR complex protein NPRL3, ... 著者 Egri, S.B, Shen, K. 登録日 2021-12-07 公開日 2022-04-06 最終更新日 2022-06-01 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism. Mol.Cell, 82, 2022
5X6U	Crystal structure of human heteropentameric complex 分子名称: Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, Ragulator complex protein LAMTOR3, ... 著者 Yonehara, R, Nada, S, Nakai, T, Nakai, M, Kitamura, A, Ogawa, A, Nakatsumi, H, Nakayama, K.I, Li, S, Standley, D.M, Yamashita, E, Nakagawa, A, Okada, M. 登録日 2017-02-23 公開日 2017-12-06 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural basis for the assembly of the Ragulator-Rag GTPase complex. Nat Commun, 8, 2017
5X6V	Crystal structure of human heteroheptameric complex 分子名称: ACETATE ION, Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, ... 著者 Yonehara, R, Nada, S, Nakai, T, Nakai, M, Kitamura, A, Ogawa, A, Nakatsumi, H, Nakayama, K.I, Li, S, Standley, D.M, Yamashita, E, Nakagawa, A, Okada, M. 登録日 2017-02-23 公開日 2017-12-06 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Structural basis for the assembly of the Ragulator-Rag GTPase complex. Nat Commun, 8, 2017
5WBL	Crystal structure of the Arabidopsis thaliana Raptor in complex with the TOS peptide of human PRAS40 分子名称: Proline-rich AKT1 substrate 1, Regulatory-associated protein of TOR 1 著者 Pavletich, N.P, Jiang, X. 登録日 2017-06-29 公開日 2017-12-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.35 Å) 主引用文献 Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
5WBK	Crystal structure of the arabidopsis thaliana Raptor in complex with the TOS peptide of human S6K1 分子名称: Regulatory-associated protein of TOR 1, Ribosomal protein S6 kinase beta-1 著者 Pavletich, N.P, Jiang, X. 登録日 2017-06-29 公開日 2017-12-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.11 Å) 主引用文献 Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
5WBI	Crystal structure of the Arabidopsis thaliana Raptor 分子名称: Regulatory-associated protein of TOR 1 著者 Pavletich, N.P, Jiang, X. 登録日 2017-06-29 公開日 2017-12-20 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
4UED	Complex of human eIF4E with the 4E binding protein 4E-BP1 分子名称: EUKARYOTIC TRANSLATION FACTOR 4E-BINDING PROTEIN 1, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E 著者 Peter, D, Weichenrieder, O. 登録日 2014-12-16 公開日 2015-02-25 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Molecular Architecture of 4E-BP Translational Inhibitors Bound to Eif4E. Mol.Cell, 57, 2015
8Y0U	dormant ribosome with STM1 分子名称: 18S rRNA, 25S rRNA, 40S ribosomal protein S1-A, ... 著者 Du, M, Zeng, F. 登録日 2024-01-23 公開日 2024-02-07 実験手法 ELECTRON MICROSCOPY (3.59 Å) 主引用文献 dormant ribosome with STM1 To Be Published
8DHB	Active FLCN GAP complex 分子名称: BERYLLIUM TRIFLUORIDE ION, Folliculin, Folliculin-interacting protein 2, ... 著者 Jansen, R.M, Hurley, J.H. 登録日 2022-06-25 公開日 2022-09-28 実験手法 ELECTRON MICROSCOPY (3.53 Å) 主引用文献 Structural basis for FLCN RagC GAP activation in MiT-TFE substrate-selective mTORC1 regulation. Sci Adv, 8, 2022
5Y39	Crystal structure of Ragulator complex (p18 76-145) 分子名称: Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, Ragulator complex protein LAMTOR3, ... 著者 Zhang, T, Ding, J. 登録日 2017-07-28 公開日 2017-12-06 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1 Nat Commun, 8, 2017

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