7N93

P70 S6K1 IN COMPLEX WITH MSC2363318A-1

Summary for 7N93

• Entry DOI: 10.2210/pdb7n93/pdb
• Related: 7N91
• Descriptor: Ribosomal protein S6 kinase beta-1, 4-({(1S)-2-(azetidin-1-yl)-1-[4-chloro-3-(trifluoromethyl)phenyl]ethyl}amino)quinazoline-8-carboxamide (3 entities in total)
• Functional Keywords: kinase domain, inhibitor, transferase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 77992.23

Authors

Mochalkin, I. (deposition date: 2021-06-16, release date: 2022-07-06, Last modification date: 2023-10-18)

• Primary citation: DeSelm, L.,Huck, B.,Lan, R.,Neagu, C.,Potnick, J.,Xiao, Y.,Chen, X.,Jones, R.,Richardson, T.E.,Heasley, B.H.,Haxell, T.,Moore, J.,Tian, H.,Georgi, K.,Rohdich, F.,Sutton, A.,Johnson, T.,Mochalkin, I.,Jackson, J.,Lin, J.,Crowley, L.,Machl, A.,Clark, A.,Wilker, E.,Sherer, B.,Goutopoulos, A.; Identification of Clinical Candidate M2698, a Dual p70S6K and Akt Inhibitor, for Treatment of PAM Pathway-Altered Cancers.; J.Med.Chem., 64:14603-14619, 2021; PubMed: 34596404; DOI: 10.1021/acs.jmedchem.1c01087

Experimental method

X-RAY DIFFRACTION (2.74 Å)