7N93
P70 S6K1 IN COMPLEX WITH MSC2363318A-1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Ribosomal protein S6 kinase beta-1 | polymer | 340 | 38546.3 | 2 | UniProt (P23443) Pfam (PF00069) Pfam (PF00433) | Homo sapiens (Human) | S6K-beta-1,S6K1,70 kDa ribosomal protein S6 kinase 1,P70S6K1,p70-S6K 1,Ribosomal protein S6 kinase I,Serine/threonine-protein kinase 14A,p70 ribosomal S6 kinase alpha,p70 S6 kinase alpha,p70 S6K-alpha,p70 S6KA |
| 2 | C, D (A, B) | 4-({(1S)-2-(azetidin-1-yl)-1-[4-chloro-3-(trifluoromethyl)phenyl]ethyl}amino)quinazoline-8-carboxamide | non-polymer | 449.9 | 2 | Chemie (1SK) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
A, B: 82 - 421 (UniProt: P23443)
| PDB | External Database | Details |
|---|---|---|
| Glu 412 | Thr 412 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 77092.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 899.7 | |
| All* | Total formula weight | 77992.2 |
