4GQ3
| Human menin with bound inhibitor MI-2 | 分子名称: | 4-[4-(5,5-dimethyl-4,5-dihydro-1,3-thiazol-2-yl)piperazin-1-yl]-6-propylthieno[2,3-d]pyrimidine, DI(HYDROXYETHYL)ETHER, Menin, ... | 著者 | Shi, A, Murai, M.J, He, S, Lund, G.L, Hartley, T, Purohit, T, Reddy, G, Chruszcz, M, Grembecka, J, Cierpicki, T. | 登録日 | 2012-08-22 | 公開日 | 2012-09-19 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia. Blood, 120, 2012
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4GQ4
| Human menin with bound inhibitor MI-2-2 | 分子名称: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-[4-(5,5-dimethyl-4,5-dihydro-1,3-thiazol-2-yl)piperazin-1-yl]-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidine, ... | 著者 | Shi, A, Murai, M.J, He, S, Lund, G.L, Hartley, T, Purohit, T, Reddy, G, Chruszcz, M, Grembecka, J, Cierpicki, T. | 登録日 | 2012-08-22 | 公開日 | 2012-09-19 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.27 Å) | 主引用文献 | Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia. Blood, 120, 2012
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4GQ6
| Human menin in complex with MLL peptide | 分子名称: | Histone-lysine N-methyltransferase MLL, Menin, PENTAETHYLENE GLYCOL, ... | 著者 | Shi, A, Murai, M.J, He, S, Lund, G.L, Hartley, T, Purohit, T, Reddy, G, Chruszcz, M, Grembecka, J, Cierpicki, T. | 登録日 | 2012-08-22 | 公開日 | 2012-09-19 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia. Blood, 120, 2012
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4GPQ
| Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, Menin, ... | 著者 | Shi, A, Murai, M.J, He, S, Lund, G.L, Hartley, T, Purohit, T, Reddy, G, Chruszcz, M, Grembecka, J, Cierpicki, T. | 登録日 | 2012-08-21 | 公開日 | 2012-09-19 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | 主引用文献 | Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia. Blood, 120, 2012
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5DDB
| Menin in complex with MI-319 | 分子名称: | 4-{4-[5-(difluoromethyl)-1,3,4-thiadiazol-2-yl]piperazin-1-yl}-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidine, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | 著者 | Pollock, J, Dmitry, B, Cierpicki, T, Grembecka, J. | 登録日 | 2015-08-24 | 公開日 | 2015-09-09 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Rational Design of Orthogonal Multipolar Interactions with Fluorine in Protein-Ligand Complexes. J.Med.Chem., 58, 2015
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5DDC
| Menin in complex with MI-2-3 | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 6-(2,2,2-trifluoroethyl)-4-{4-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]piperazin-1-yl}thieno[2,3-d]pyrimidine, DI(HYDROXYETHYL)ETHER, ... | 著者 | Pollock, J, Dmitry, B, Cierpicki, T, Grembecka, J. | 登録日 | 2015-08-24 | 公開日 | 2016-07-06 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Rational Design of Orthogonal Multipolar Interactions with Fluorine in Protein-Ligand Complexes. J.Med.Chem., 58, 2015
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5DDA
| Menin in complex with MI-333 | 分子名称: | 1,2-ETHANEDIOL, 4-{4-[5-(fluoromethyl)-1,3,4-thiadiazol-2-yl]piperazin-1-yl}-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidine, DIMETHYL SULFOXIDE, ... | 著者 | Pollock, J, Dmitry, B, Cierpicki, T, Grembecka, J. | 登録日 | 2015-08-24 | 公開日 | 2015-09-09 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | Rational Design of Orthogonal Multipolar Interactions with Fluorine in Protein-Ligand Complexes. J.Med.Chem., 58, 2015
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5DDF
| Menin in complex with MI-273 | 分子名称: | 4-[4-(5,5-dimethyl-4,5-dihydro-1,3-thiazol-2-yl)piperazin-1-yl]-6-(pentafluoroethyl)thieno[2,3-d]pyrimidine, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | 著者 | Pollock, J, Dmitry, B, Cierpicki, T, Grembecka, J. | 登録日 | 2015-08-24 | 公開日 | 2015-09-09 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | 主引用文献 | Rational Design of Orthogonal Multipolar Interactions with Fluorine in Protein-Ligand Complexes. J.Med.Chem., 58, 2015
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5DB0
| Menin in complex with MI-352 | 分子名称: | 1-[(2R)-2,3-dihydroxypropyl]-5-[(4-{[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino}piperidin-1-yl)methyl]-1H-indole-2-carbonitrile, 1-[(2S)-2,3-dihydroxypropyl]-5-[(4-{[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino}piperidin-1-yl)methyl]-1 H-indole-2-carbonitrile, DIMETHYL SULFOXIDE, ... | 著者 | Pollock, J, Dmitry, B, Cierpicki, T, Grembecka, J. | 登録日 | 2015-08-20 | 公開日 | 2016-03-30 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL). J.Med.Chem., 59, 2016
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5DD9
| Menin in complex with MI-326 | 分子名称: | 4-[4-(5-methyl-1,3,4-thiadiazol-2-yl)piperazin-1-yl]-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidine, DIMETHYL SULFOXIDE, Menin, ... | 著者 | Pollock, J, Dmitry, B, Cierpicki, T, Grembecka, J. | 登録日 | 2015-08-24 | 公開日 | 2015-09-09 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Rational Design of Orthogonal Multipolar Interactions with Fluorine in Protein-Ligand Complexes. J.Med.Chem., 58, 2015
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5DB3
| Menin in complex with MI-574 | 分子名称: | 6-methoxy-4-methyl-1-(1H-pyrazol-4-ylmethyl)-5-[(4-{[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino}piperidin-1-yl)methyl]-1H-indole-2-carbonitrile, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | 著者 | Pollock, J, Borkin, D, Cierpicki, T, Grembecka, J. | 登録日 | 2015-08-20 | 公開日 | 2016-03-30 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | 主引用文献 | Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL). J.Med.Chem., 59, 2016
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5DDD
| menin in complex with MI-836 | 分子名称: | 4-[4-(5,5-dimethyl-4,5-dihydro-1,3-thiazol-2-yl)piperazin-1-yl]-6-(2-fluoroethyl)thieno[2,3-d]pyrimidine, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | 著者 | Pollock, J, Dmitry, B, Cierpicki, T, Grembecka, J. | 登録日 | 2015-08-24 | 公開日 | 2015-09-09 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | 主引用文献 | Rational Design of Orthogonal Multipolar Interactions with Fluorine in Protein-Ligand Complexes. J.Med.Chem., 58, 2015
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5DB2
| Menin in complex with MI-389 | 分子名称: | 2-{2-cyano-5-[(4-{[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino}piperidin-1-yl)methyl]-1H-indol-1-yl}aceta mide, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | 著者 | Pollock, J, Dmitry, B, Cierpicki, T, Grembecka, J. | 登録日 | 2015-08-20 | 公開日 | 2016-03-30 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL). J.Med.Chem., 59, 2016
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5DDE
| Menin in complex with MI-859 | 分子名称: | 1,2-ETHANEDIOL, 6-(2,2-difluoroethyl)-4-[4-(5,5-dimethyl-4,5-dihydro-1,3-thiazol-2-yl)piperazin-1-yl]thieno[2,3-d]pyrimidine, DIMETHYL SULFOXIDE, ... | 著者 | Pollock, J, Dmitry, B, Cierpicki, T, Grembecka, J. | 登録日 | 2015-08-24 | 公開日 | 2015-09-09 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Rational Design of Orthogonal Multipolar Interactions with Fluorine in Protein-Ligand Complexes. J.Med.Chem., 58, 2015
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5DB1
| Menin in complex with MI-336 | 分子名称: | 6-methoxy-5-[(4-{[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino}piperidin-1-yl)methyl]-1H-indole-2-carbonitrile, DIMETHYL SULFOXIDE, Menin, ... | 著者 | Pollock, J, Dmitry, B, Cierpicki, T, Grembecka, J. | 登録日 | 2015-08-20 | 公開日 | 2016-03-30 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL). J.Med.Chem., 59, 2016
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2KC6
| NMR solution structure of the pheromone En-1 of Euplotes nobilii at -1.5 C | 分子名称: | Mating pheromone En-1 | 著者 | Pedrini, B, Alimenti, C, Vallesi, A, Luporini, P, Wuthrich, K. | 登録日 | 2008-12-17 | 公開日 | 2009-08-04 | 最終更新日 | 2022-03-16 | 実験手法 | SOLUTION NMR | 主引用文献 | Molecular cold-adaptation: Comparative analysis of two homologous families of psychrophilic and mesophilic signal proteins of the protozoan ciliate, Euplotes. Iubmb Life, 61, 2009
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2NSV
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8GPN
| Human menin in complex with H3K79Me2 nucleosome | 分子名称: | DNA (177-MER), Histone H2A type 1, Histone H2B 1.1, ... | 著者 | Lin, J, Yu, D, Lam, W.H, Dang, S, Zhai, Y, Li, X.D. | 登録日 | 2022-08-26 | 公開日 | 2023-02-15 | 最終更新日 | 2023-03-01 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Menin "reads" H3K79me2 mark in a nucleosomal context. Science, 379, 2023
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8PXX
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6S2K
| Human Menin in complex with AJ21 | 分子名称: | Multiple endocrine neoplasia I, isoform CRA_b, ~{N}-[2-(4-methoxyphenyl)ethyl]-2-(4-nitrophenyl)imidazo[1,2-a]pyridin-3-amine | 著者 | Groves, M.R, Gao, K. | 登録日 | 2019-06-21 | 公開日 | 2021-01-13 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Human Menin in complex with AJ21 To Be Published
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3RE2
| Crystal structure of menin reveals the binding site for Mixed Lineage Leukemia (MLL) protein | 分子名称: | GLYCEROL, Predicted protein | 著者 | Murai, M.J, Chruszcz, M, Reddy, G, Grembecka, J, Cierpicki, T. | 登録日 | 2011-04-02 | 公開日 | 2011-07-13 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Crystal Structure of Menin Reveals Binding Site for Mixed Lineage Leukemia (MLL) Protein. J.Biol.Chem., 286, 2011
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7VH9
| Solution structure of the chimeric peptide of the first SURP domain of Human SF3A1 and the interacting region of SF1. | 分子名称: | Splicing factor 3A subunit 1,Splicing factor 1 | 著者 | Muto, Y, Kuwasako, K, Takizawa, M, Kobayashi, N, Sakamoto, T. | 登録日 | 2021-09-21 | 公開日 | 2022-09-28 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural basis for the interaction between the first SURP domain of the SF3A1 subunit in U2 snRNP and the human splicing factor SF1. Protein Sci., 31, 2022
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7VPX
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7O9T
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7O9X
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