7OLE
| Cryo-EM structure of the TELO2-TTI1-TTI2-RUVBL1-RUVBL2 complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, RuvB-like 1, RuvB-like 2, ... | Authors: | Pal, M, Llorca, O, Pearl, L. | Deposit date: | 2021-05-19 | Release date: | 2021-07-07 | Last modified: | 2021-10-06 | Method: | ELECTRON MICROSCOPY (3.41 Å) | Cite: | Structure of the TELO2-TTI1-TTI2 complex and its function in TOR recruitment to the R2TP chaperone. Cell Rep, 36, 2021
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7P6X
| Cryo-Em structure of the hexameric RUVBL1-RUVBL2 in complex with ZNHIT2 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, RuvB-like 1, RuvB-like 2 | Authors: | Llorca, O, Serna, M, Fernandez-Leiro, R. | Deposit date: | 2021-07-18 | Release date: | 2021-12-15 | Last modified: | 2023-01-25 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | CryoEM of RUVBL1-RUVBL2-ZNHIT2, a complex that interacts with pre-mRNA-processing-splicing factor 8. Nucleic Acids Res., 50, 2022
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6FO1
| Human R2TP subcomplex containing 1 RUVBL1-RUVBL2 hexamer bound to 1 RBD domain from RPAP3. | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, RNA polymerase II-associated protein 3, RuvB-like 1, ... | Authors: | Martino, F, Munoz-Hernandez, H, Rodriguez, C.F, Pearl, L.H, Llorca, O. | Deposit date: | 2018-02-05 | Release date: | 2018-04-04 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (3.57 Å) | Cite: | RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex. Nat Commun, 9, 2018
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6IGM
| Cryo-EM Structure of Human SRCAP Complex | Descriptor: | Actin-related protein 6, Helicase SRCAP, RuvB-like 1, ... | Authors: | Feng, Y, Tian, Y, Wu, Z, Xu, Y. | Deposit date: | 2018-09-25 | Release date: | 2019-07-24 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Cryo-EM structure of human SRCAP complex. Cell Res., 28, 2018
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9EMA
| RUVBL1/2 in complex with ATP and CB-6644 inhibitor | Descriptor: | 5-chloranyl-2-ethoxy-4-fluoranyl-~{N}-[4-[[3-(methoxymethyl)-1-oxidanylidene-6,7-dihydro-5~{H}-pyrazolo[1,2-a][1,2]benzodiazepin-2-yl]amino]-2,2-dimethyl-4-oxidanylidene-butyl]benzamide, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Lopez-Perrote, A, Llorca, O, Garcia-Martin, C. | Deposit date: | 2024-03-07 | Release date: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Mechanism of allosteric inhibition of RUVBL1-RUVBL2 by the small-molecule CB-6644 Cell Rep Phys Sci, 2024
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9EMC
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2XSZ
| The dodecameric human RuvBL1:RuvBL2 complex with truncated domains II | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, RUVB-LIKE 1, RUVB-LIKE 2 | Authors: | Gorynia, S, Bandeiras, T.M, Matias, P.M, Pinho, F.G, McVey, C.E, Vonrhein, C, Svergun, D.I, Round, A, Donner, P, Carrondo, M.A. | Deposit date: | 2010-10-01 | Release date: | 2011-10-05 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural and Functional Insights Into a Dodecameric Molecular Machine - the Ruvbl1/Ruvbl2 Complex. J.Struct.Biol., 176, 2011
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4UF5
| Crystal structure of UCH-L5 in complex with inhibitory fragment of INO80G | Descriptor: | NUCLEAR FACTOR RELATED TO KAPPA-B-BINDING PROTEIN, UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5 | Authors: | Sahtoe, D.D, Van Dijk, W.J, El Oualid, F, Ekkebus, R, Ovaa, H, Sixma, T.K. | Deposit date: | 2014-12-23 | Release date: | 2015-03-04 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Mechanism of Uch-L5 Activation and Inhibition by Deubad Domains in Rpn13 and Ino80G. Mol.Cell, 57, 2015
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4UF6
| UCH-L5 in complex with ubiquitin-propargyl bound to an activating fragment of INO80G | Descriptor: | NUCLEAR FACTOR RELATED TO KAPPA-B-BINDING PROTEIN, POLYUBIQUITIN-B, UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5 | Authors: | Sahtoe, D.D, Van Dijk, W.J, El Oualid, F, Ekkebus, R, Ovaa, H, Sixma, T.K. | Deposit date: | 2014-12-23 | Release date: | 2015-03-04 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (3.69 Å) | Cite: | Mechanism of Uch-L5 Activation and Inhibition by Deubad Domains in Rpn13 and Ino80G. Mol.Cell, 57, 2015
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3IHR
| Crystal Structure of Uch37 | Descriptor: | FORMIC ACID, SODIUM ION, Ubiquitin carboxyl-terminal hydrolase isozyme L5 | Authors: | Burgie, E.S, Bingman, C.A, Phillips Jr, G.N, Center for Eukaryotic Structural Genomics (CESG) | Deposit date: | 2009-07-30 | Release date: | 2009-08-11 | Last modified: | 2023-07-26 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Structural characterization of human Uch37. Proteins, 80, 2012
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6H7X
| First X-ray structure of full-length human RuvB-Like 2. | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, ... | Authors: | Silva, S, Brito, J.A, Matias, P, Bandeiras, T. | Deposit date: | 2018-07-31 | Release date: | 2018-08-08 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.892 Å) | Cite: | X-ray structure of full-length human RuvB-Like 2 - mechanistic insights into coupling between ATP binding and mechanical action. Sci Rep, 8, 2018
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7VDV
| The overall structure of human chromatin remodeling PBAF-nucleosome complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, AT-rich interactive domain-containing protein 2,AT-rich interactive domain-containing protein 2, Actin, ... | Authors: | Chen, Z.C, Chen, K.J, Yuan, J.J. | Deposit date: | 2021-09-07 | Release date: | 2022-05-18 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure of human chromatin-remodelling PBAF complex bound to a nucleosome. Nature, 605, 2022
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4RWT
| Structure of actin-Lmod complex | Descriptor: | Actin-5C, Leiomodin-2, MAGNESIUM ION, ... | Authors: | Chen, X, Ni, F, Wang, Q. | Deposit date: | 2014-12-05 | Release date: | 2015-10-14 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.98 Å) | Cite: | Mechanisms of leiomodin 2-mediated regulation of actin filament in muscle cells. Proc.Natl.Acad.Sci.USA, 112, 2015
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4C5I
| Crystal structure of MBTD1 YY1 complex | Descriptor: | MBT DOMAIN-CONTAINING PROTEIN 1, TRANSCRIPTIONAL REPRESSOR PROTEIN YY1 | Authors: | Alfieri, C, Glatt, S, Mueller, C.W. | Deposit date: | 2013-09-12 | Release date: | 2013-11-13 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.586 Å) | Cite: | Structural Basis for Targeting the Chromatin Repressor Sfmbt to Polycomb Response Elements Genes Dev., 27, 2013
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5JXT
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5JXR
| Crystal structure of MtISWI | Descriptor: | CHLORIDE ION, Chromatin-remodeling complex ATPase-like protein | Authors: | Chen, Z, Yan, L. | Deposit date: | 2016-05-13 | Release date: | 2016-12-07 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.404 Å) | Cite: | Structure and regulation of the chromatin remodeller ISWI Nature, 540, 2016
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5SVA
| Mediator-RNA Polymerase II Pre-Initiation Complex | Descriptor: | 108bp HIS4 Promoter Non-template Strand (-92/+16), 108bp HIS4 Promoter Template Strand (+16/-92), DNA repair helicase RAD25, ... | Authors: | Robinson, P.J, Bushnell, D.A, Kornberg, R.D. | Deposit date: | 2016-08-05 | Release date: | 2016-09-28 | Last modified: | 2019-11-27 | Method: | ELECTRON MICROSCOPY (15.3 Å) | Cite: | Structure of a Complete Mediator-RNA Polymerase II Pre-Initiation Complex. Cell, 166, 2016
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5TGC
| Structure of the hetero-trimer of Rtt102-Arp7/9 bound to ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin-like protein ARP9, Actin-related protein 7, ... | Authors: | Turegun, B, Dominguez, R. | Deposit date: | 2016-09-27 | Release date: | 2017-09-06 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.245 Å) | Cite: | Actin-related proteins regulate the RSC chromatin remodeler by weakening intramolecular interactions of the Sth1 ATPase. Commun Biol, 1, 2018
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4JHD
| Crystal Structure of an Actin Dimer in Complex with the Actin Nucleator Cordon-Bleu | Descriptor: | Actin-5C, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Chen, X, Ni, F, Wang, Q. | Deposit date: | 2013-03-04 | Release date: | 2013-06-19 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.91 Å) | Cite: | Structural basis of actin filament nucleation by tandem w domains. Cell Rep, 3, 2013
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1YAG
| STRUCTURE OF THE YEAST ACTIN-HUMAN GELSOLIN SEGMENT 1 COMPLEX | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, MAGNESIUM ION, ... | Authors: | Vorobiev, S, Strokopytov, B, Frieden, C, Almo, S.C. | Deposit date: | 1998-10-09 | Release date: | 1999-10-09 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The structure of nonvertebrate actin: Implications for the ATP
hydrolytic mechanism Proc.Natl.Acad.Sci.USA, 100, 2003
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3A7S
| Catalytic domain of UCH37 | Descriptor: | CHLORIDE ION, Ubiquitin carboxyl-terminal hydrolase isozyme L5 | Authors: | Nishio, K, Kim, S.W, Kawai, K, Mizushima, T, Yamane, T, Hamazaki, J, Murata, S, Tanaka, K. | Deposit date: | 2009-10-04 | Release date: | 2009-11-03 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of the de-ubiquitinating enzyme UCH37 (human UCH-L5) catalytic domain Biochem.Biophys.Res.Commun., 2009
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1YVN
| THE YEAST ACTIN VAL 159 ASN MUTANT COMPLEX WITH HUMAN GELSOLIN SEGMENT 1. | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, MAGNESIUM ION, ... | Authors: | Vorobiev, S.M, Belmont, L.D, Drubin, D.G, Almo, S.C. | Deposit date: | 1999-03-23 | Release date: | 2000-03-23 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of yeast actin V159N mutant To be Published
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4M63
| Crystal Structure of a Filament-Like Actin Trimer Bound to the Bacterial Effector VopL | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin-5C, CALCIUM ION, ... | Authors: | Tomchick, D.R, Zahm, J.A, Rosen, M.K. | Deposit date: | 2013-08-08 | Release date: | 2013-10-23 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.748 Å) | Cite: | The Bacterial Effector VopL Organizes Actin into Filament-like Structures. Cell(Cambridge,Mass.), 155, 2013
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3UK6
| Crystal Structure of the Tip48 (Tip49b) hexamer | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, RuvB-like 2 | Authors: | Petukhov, M, Dagkessamanskaja, A, Bommer, M, Barrett, T, Tsaneva, I, Yakimov, A, Queval, R, Shvetsov, A, Khodorkovskiy, M, Kas, E, Grigoriev, M. | Deposit date: | 2011-11-09 | Release date: | 2012-07-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Large-Scale Conformational Flexibility Determines the Properties of AAA+ TIP49 ATPases. Structure, 20, 2012
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5FM6
| Double-heterohexameric rings of full-length Rvb1(ADP)Rvb2(apo) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, PHOSPHATE ION, RVB1, ... | Authors: | Silva-Martin, N, Dauden, M.I, Glatt, S, Hoffmann, N.A, Mueller, C.W. | Deposit date: | 2015-11-02 | Release date: | 2016-01-20 | Method: | X-RAY DIFFRACTION (2.997 Å) | Cite: | The Combination of X-Ray Crystallography and Cryo-Electron Microscopy Provides Insight Into the Overall Architecture of the Dodecameric Rvb1/Rvb2 Complex. Plos One, 11, 2016
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