PDB: 250 件ウェブページステータス検索Chemie searchBIRD

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6I8Y	Crystal structure of Spindlin1 in complex with the Methyltransferase inhibitor A366 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 5'-methoxy-6'-[3-(pyrrolidin-1-yl)propoxy]spiro[cyclobutane-1,3'-indol]-2'-amine, ... 著者 Srikannathasan, V, Johansson, C, Gileadi, C, Shrestha, L, Sorrell, F.J, Krojer, T, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A, Oppermann, U.C.T. 登録日 2018-11-21 公開日 2018-12-26 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function. J.Med.Chem., 62, 2019
6J2P	Crystal structure of Saccharomyces cerevisiae Spp1 in complex with H3K4me3 分子名称: COMPASS component SPP1, Histone H3, ZINC ION 著者 He, C, Li, F. 登録日 2019-01-02 公開日 2019-09-11 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Structural basis for histone H3K4me3 recognition by the N-terminal domain of the PHD finger protein Spp1. Biochem.J., 476, 2019
6L87	Solution structure of the tandem PWWP-ARID domains of human RBBP1 分子名称: AT-rich interactive domain-containing protein 4A 著者 Gong, W.B, Perrett, S, Feng, Y.G. 登録日 2019-11-05 公開日 2021-01-06 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Structural insight into chromatin recognition by multiple domains of the tumor suppressor RBBP1. J.Mol.Biol., 2021
6LQE	Crystal structure of Arabidopsis ARID5 PHD finger in complex with H3K4me3 peptide 分子名称: 15-mer peptide from Histone H3.2, AT-rich interactive domain-containing protein 4, ZINC ION 著者 Liu, R, Du, J. 登録日 2020-01-13 公開日 2020-06-03 最終更新日 2020-08-19 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Dual Recognition of H3K4me3 and DNA by the ISWI Component ARID5 Regulates the Floral Transition in Arabidopsis. Plant Cell, 32, 2020
6LQF	Crystal structure of Arabidopsis ARID5 ARID-PHD cassette in complex with H3K4me3 peptide and DNA 分子名称: 15-mer peptide from Histone H3.2, AT-rich interactive domain-containing protein 4, DNA (5'-D(*TP*TP*TP*AP*GP*AP*TP*CP*TP*AP*AP*A)-3'), ... 著者 Liu, R, Du, J. 登録日 2020-01-13 公開日 2020-06-03 最終更新日 2020-08-19 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Dual Recognition of H3K4me3 and DNA by the ISWI Component ARID5 Regulates the Floral Transition in Arabidopsis. Plant Cell, 32, 2020
6LUI	Crystal structure of the SAMD1 WH domain and DNA complex 分子名称: Atherin, DNA (5'-D(*AP*CP*CP*TP*GP*CP*GP*CP*AP*CP*CP*AP*T)-3'), DNA (5'-D(*AP*TP*GP*GP*TP*GP*CP*GP*CP*AP*GP*GP*T)-3') 著者 Zhou, Y, Cao, Y, Wang, Z. 登録日 2020-01-29 公開日 2021-02-03 最終更新日 2021-07-07 実験手法 X-RAY DIFFRACTION (1.781 Å) 主引用文献 The SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands. Sci Adv, 7, 2021
6LUJ	Crystal structure of the SAMD1 SAM domain 分子名称: Atherin, SULFATE ION 著者 Cao, Y, Zhou, Y, Wang, Z. 登録日 2020-01-29 公開日 2021-02-03 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.12 Å) 主引用文献 The SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands. Sci Adv, 7, 2021
6LUK	Crystal structure of the SAMD1 SAM domain in another crystal form 分子名称: Atherin, SULFATE ION 著者 Cao, Y, Zhou, Y, Wang, Z. 登録日 2020-01-29 公開日 2021-02-03 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.054 Å) 主引用文献 The SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands. Sci Adv, 7, 2021
6QPL	Crystal structure of Spindlin1 in complex with the inhibitor MS31 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, DIMETHYL SULFOXIDE, GLYCEROL, ... 著者 Johansson, C, Krojer, T, Xiong, Y, Jin, J, Arrowsmith, C.H, Bountra, C, Edwards, A, Oppermann, U.C.T. 登録日 2019-02-14 公開日 2019-07-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1). J.Med.Chem., 62, 2019
6R1U	Structure of LSD2/NPAC-linker/nucleosome core particle complex: Class 2 分子名称: DNA (147-MER), FLAVIN-ADENINE DINUCLEOTIDE, Histone H2A, ... 著者 Marabelli, C, Pilotto, S, Chittori, S, Subramaniam, S, Mattevi, A. 登録日 2019-03-15 公開日 2019-04-24 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (4.36 Å) 主引用文献 A Tail-Based Mechanism Drives Nucleosome Demethylation by the LSD2/NPAC Multimeric Complex. Cell Rep, 27, 2019
6R25	Structure of LSD2/NPAC-linker/nucleosome core particle complex: Class 3 分子名称: DNA (147-MER), FLAVIN-ADENINE DINUCLEOTIDE, H2B, ... 著者 Marabelli, C, Pilotto, S, Chittori, S, Subramaniam, S, Mattevi, A. 登録日 2019-03-15 公開日 2019-04-24 実験手法 ELECTRON MICROSCOPY (4.61 Å) 主引用文献 A Tail-Based Mechanism Drives Nucleosome Demethylation by the LSD2/NPAC Multimeric Complex. Cell Rep, 27, 2019
6TE1	Structure of the KDM1A/CoREST complex with the inhibitor 2-[3-{4-chloro-3-[(4-chlorophenyl)ethynyl]phenyl}-1-(3-morpholin-4-ylpropyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]-2-oxoethanol 分子名称: 5-[4-cyclobutyl-1-[2-(4-piperidin-4-yloxyphenoxy)ethyl]imidazol-2-yl]-4-methyl-thieno[3,2-b]pyrrole, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... 著者 Pasqualato, S, Cecatiello, V. 登録日 2019-11-11 公開日 2020-06-03 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3.11 Å) 主引用文献 Discovery of Reversible Inhibitors of KDM1A Efficacious in Acute Myeloid Leukemia Models. Acs Med.Chem.Lett., 11, 2020
6TUY	Human LSD1/CoREST bound to the quinazoline inhibitor MC4106 分子名称: CHLORIDE ION, DIMETHYL SULFOXIDE, FLAVIN-ADENINE DINUCLEOTIDE, ... 著者 Mattevi, A, Marrocco, B. 登録日 2020-01-08 公開日 2021-07-21 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models. Eur.J.Med.Chem., 237, 2022
6VHF	Crystal structure of RbBP5 interacting domain of Cfp1 分子名称: PHD-type domain-containing protein, ZINC ION 著者 Joshi, M, Couture, J.F. 登録日 2020-01-09 公開日 2020-01-22 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.311 Å) 主引用文献 A non-canonical monovalent zinc finger stabilizes the integration of Cfp1 into the H3K4 methyltransferase complex COMPASS. Nucleic Acids Res., 48, 2020
6W5I	Cryo-EM structure of MLL1 in complex with RbBP5, WDR5, SET1, and ASH2L bound to the nucleosome (Class01) 分子名称: DNA (147-MER), Histone H2A, Histone H2B 1.1, ... 著者 Park, S.H, Lee, Y.T, Ayoub, A, Dou, Y, Cho, U. 登録日 2020-03-13 公開日 2021-03-31 最終更新日 2022-10-12 実験手法 ELECTRON MICROSCOPY (6.9 Å) 主引用文献 Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin. Nat Commun, 12, 2021
6W5M	Cryo-EM structure of MLL1 in complex with RbBP5, WDR5, SET1, and ASH2L bound to the nucleosome (Class02) 分子名称: DNA (147-MER), Histone H2A type 1, Histone H2B 1.1, ... 著者 Park, S.H, Lee, Y.T, Ayoub, A, Dou, Y, Cho, U. 登録日 2020-03-13 公開日 2021-03-31 最終更新日 2022-10-12 実験手法 ELECTRON MICROSCOPY (4.6 Å) 主引用文献 Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin. Nat Commun, 12, 2021
6W5N	Cryo-EM structure of MLL1 in complex with RbBP5, WDR5, SET1, and ASH2L bound to the nucleosome (Class05) 分子名称: DNA (147-MER), Histone H2A type 1, Histone H2B 1.1, ... 著者 Park, S.H, Lee, Y.T, Ayoub, A, Dou, Y, Cho, U. 登録日 2020-03-13 公開日 2021-03-31 最終更新日 2022-10-12 実験手法 ELECTRON MICROSCOPY (6 Å) 主引用文献 Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin. Nat Commun, 12, 2021
6WKR	PRC2-AEBP2-JARID2 bound to H2AK119ub1 nucleosome 分子名称: DNA (314-MER), Histone H2A type 1, Histone H2B 1.1, ... 著者 Kasinath, V, Nogales, E, Beck, C, Sauer, P, Poepsel, S, Kosmatka, J, Faini, M, Toso, D, Aebersold, R. 登録日 2020-04-16 公開日 2021-02-03 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications. Science, 371, 2021
6WXK	PHF23 PHD Domain Apo 分子名称: PHD finger protein 23, ZINC ION 著者 Vann, K.R, Zhang, J, Zhang, Y, Kutateladze, T. 登録日 2020-05-11 公開日 2020-07-15 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion. Nat Commun, 11, 2020
7BCY	X-ray structure of WDR5delta24 bound to the Kaposi's sarcoma herpesvirus LANA win motif peptide 分子名称: ORF 73, WD repeat-containing protein 5 著者 McVey, C.E, Kaye, K.M. 登録日 2020-12-21 公開日 2021-12-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 MLL1 is regulated by KSHV LANA and is important for virus latency. Nucleic Acids Res., 49, 2021
7BED	X-ray structure of WDR5 bound to the WDR5 win motif peptide 分子名称: SULFATE ION, WD repeat-containing protein 5 著者 McVey, C.E, Kaye, K.M. 登録日 2020-12-23 公開日 2021-12-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.26 Å) 主引用文献 MLL1 is regulated by KSHV LANA and is important for virus latency. Nucleic Acids Res., 49, 2021
7BQZ	Crystal Structure of Spindlin1 bound to H3(K4me3-K9me3) peptide 分子名称: H3(K4me3-K9me3) peptide, Spindlin-1 著者 Zhao, F, Li, H. 登録日 2020-03-26 公開日 2020-10-14 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.101 Å) 主引用文献 Molecular basis for histone H3 "K4me3-K9me3/2" methylation pattern readout by Spindlin1. J.Biol.Chem., 295, 2020
7BU9	Crystal Structure of Spindlin1-H3(K4me3-K9me2) complex 分子名称: H3(K4me3-K9me2) peptide, Spindlin-1 著者 Zhao, F, Li, H. 登録日 2020-04-05 公開日 2020-10-14 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.502 Å) 主引用文献 Molecular basis for histone H3 "K4me3-K9me3/2" methylation pattern readout by Spindlin1. J.Biol.Chem., 295, 2020
7CFP	Crystal structure of WDR5 in complex with a H3Q5ser peptide 分子名称: H3Q5ser peptide, SEROTONIN, WD repeat-containing protein 5 著者 Zhao, J, Zhang, X, Zang, J. 登録日 2020-06-27 公開日 2021-07-07 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural insights into the recognition of histone H3Q5 serotonylation by WDR5. Sci Adv, 7, 2021
7CFQ	Crystal structure of WDR5 in complex with H3K4me3Q5ser peptide 分子名称: 1,2-ETHANEDIOL, GLYCEROL, H3K4me3Q5ser peptide, ... 著者 Zhao, J, Zhang, X, Zang, J. 登録日 2020-06-27 公開日 2021-07-07 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural insights into the recognition of histone H3Q5 serotonylation by WDR5. Sci Adv, 7, 2021

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