1I9V
| CRYSTAL STRUCTURE ANALYSIS OF A TRNA-NEOMYCIN COMPLEX | 分子名称: | MAGNESIUM ION, NEOMYCIN, PHENYLALANINE TRANSFER RNA | 著者 | Mikkelsen, N.E, Johansson, K, Virtanen, A, Kirsebom, L.A. | 登録日 | 2001-03-21 | 公開日 | 2001-06-04 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Aminoglycoside binding displaces a divalent metal ion in a tRNA-neomycin B complex. Nat.Struct.Biol., 8, 2001
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2A04
| Molecular Recognition of RNA by Neomycin and a Restricted Neomycin Derivative | 分子名称: | 5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*AP*CP*C)-3', 5'-R(*GP*UP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*CP*GP*G)-3', MAGNESIUM ION, ... | 著者 | Zhao, Q, Zhao, F, Blount, K.F, Han, Q, Tor, Y, Hermann, T. | 登録日 | 2005-06-15 | 公開日 | 2005-09-20 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Molecular recognition of RNA by neomycin and a restricted neomycin derivative Angew.Chem.Int.Ed.Engl., 44, 2005
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7Q1X
| Acetyltrasferase(3) type IIIa in complex with neomycin B | 分子名称: | Aminoglycoside N(3)-acetyltransferase III, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Pontillo, N, Guskov, A. | 登録日 | 2021-10-21 | 公開日 | 2022-11-02 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | The 3-N-alkylation of the neomycin B outmaneuvers the aminoglycoside resistant enzyme acetyltransferase(3)IIIa via an unexpected mechanism To Be Published
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2MXS
| Solution NMR-structure of the neomycin sensing riboswitch RNA bound to paromomycin | 分子名称: | PAROMOMYCIN, RNA (27-MER) | 著者 | Schmidtke, S, Duchardt-Ferner, E, Ohlenschlaeger, O, Gottstein, D, Wohnert, J. | 登録日 | 2015-01-14 | 公開日 | 2015-12-09 | 最終更新日 | 2016-02-03 | 実験手法 | SOLUTION NMR | 主引用文献 | What a Difference an OH Makes: Conformational Dynamics as the Basis for the Ligand Specificity of the Neomycin-Sensing Riboswitch. Angew.Chem.Int.Ed.Engl., 55, 2016
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1QD3
| HIV-1 TAR RNA/NEOMYCIN B COMPLEX | 分子名称: | 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranose, 2,6-diamino-2,6-dideoxy-beta-L-idopyranose-(1-3)-alpha-D-ribofuranose, 2-DEOXYSTREPTAMINE, ... | 著者 | Faber, C, Sticht, H, Roesch, P. | 登録日 | 1999-07-07 | 公開日 | 2000-07-12 | 最終更新日 | 2023-12-27 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural rearrangements of HIV-1 Tat-responsive RNA upon binding of neomycin B. J.Biol.Chem., 275, 2000
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1ZZ5
| Molecular Recognition of RNA by Neomycin and a Restricted Neomycin Derivative | 分子名称: | 13,15-DIAMINO-2-(AMINOMETHYL)-3,4,9,12-TETRAHYDROXYHEXADECAHYDRO-2H-7,10-EPOXYPYRANO[2,3-B][1,10,4]BENZODIOXAZACYCLODODECIN-8-YL 2,6-DIAMINO-2,6-DIDEOXYHEXOPYRANOSIDE, 5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*AP*CP*C)-3', 5'-R(*GP*UP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*CP*GP*G)-3', ... | 著者 | Zhao, Q, Zhao, F, Blount, K.F, Han, Q, Tor, Y, Hermann, T. | 登録日 | 2005-06-13 | 公開日 | 2005-09-20 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Molecular recognition of RNA by neomycin and a restricted neomycin derivative Angew.Chem.Int.Ed.Engl., 44, 2005
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1NEM
| Saccharide-RNA recognition in the neomycin B / RNA aptamer complex | 分子名称: | 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranose, 2,6-diamino-2,6-dideoxy-beta-L-idopyranose-(1-3)-beta-D-ribofuranose, 2-DEOXY-D-STREPTAMINE, ... | 著者 | Jiang, L, Majumdar, A, Hu, W, Jaishree, T.J, Xu, W, Patel, D.J. | 登録日 | 1999-03-15 | 公開日 | 1999-08-31 | 最終更新日 | 2023-12-27 | 実験手法 | SOLUTION NMR | 主引用文献 | Saccharide-RNA recognition in a complex formed between neomycin B and an RNA aptamer Structure Fold.Des., 7, 1999
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7CS1
| Aminoglycoside 2'-N-acetyltransferase from Mycolicibacterium smegmatis-Complex with Coenzyme A and Neomycin | 分子名称: | Aminoglycoside 2'-N-acetyltransferase, COENZYME A, NEOMYCIN | 著者 | Jeong, C.S, Hwang, J, Do, H, Lee, J.H. | 登録日 | 2020-08-14 | 公開日 | 2021-06-23 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.966 Å) | 主引用文献 | Structural and biochemical analyses of an aminoglycoside 2'-N-acetyltransferase from Mycolicibacterium smegmatis. Sci Rep, 10, 2020
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6CBN
| x-ray structure of NeoB from streptomyces fradiae in complex with PLP and neomycin (as the external aldimine) at pH 7.5 | 分子名称: | (1R,2R,3S,4R,6S)-4,6-diamino-2-[(3-O-{2-amino-2,6-dideoxy-6-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]-alpha-D-glucopyranosyl}-beta-D-ribofuranosyl)oxy]-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside, 1,2-ETHANEDIOL, Neamine transaminase NeoN | 著者 | Thoden, J.B, Dow, G.T, Holden, H.M. | 登録日 | 2018-02-03 | 公開日 | 2018-02-21 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | The three-dimensional structure of NeoB: An aminotransferase involved in the biosynthesis of neomycin. Protein Sci., 27, 2018
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6CBM
| x-ray structure of NeoB from streptomyces fradiae in complex with PLP and neomycin (as the external aldimine) at pH 9 | 分子名称: | (1R,2R,3S,4R,6S)-4,6-diamino-2-[(3-O-{2-amino-2,6-dideoxy-6-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]-alpha-D-glucopyranosyl}-beta-D-ribofuranosyl)oxy]-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside, 1,2-ETHANEDIOL, CHLORIDE ION, ... | 著者 | Thoden, J.B, Dow, G.T, Holden, H.M. | 登録日 | 2018-02-03 | 公開日 | 2018-02-21 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | The three-dimensional structure of NeoB: An aminotransferase involved in the biosynthesis of neomycin. Protein Sci., 27, 2018
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2B0Q
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5DV4
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2N0J
| Solution NMR Structure of the 27 nucleotide engineered neomycin sensing riboswitch RNA-ribostamycin complex | 分子名称: | RIBOSTAMYCIN, RNA_(27-MER) | 著者 | Duchardt-Ferner, E, Gottstein-Schmidtke, S.R, Weigand, J.E, Ohlenschlaeger, O.E, Wurm, J, Hammann, C, Suess, B, Woehnert, J. | 登録日 | 2015-03-09 | 公開日 | 2016-02-03 | 実験手法 | SOLUTION NMR | 主引用文献 | What a Difference an OH Makes: Conformational Dynamics as the Basis for the Ligand Specificity of the Neomycin-Sensing Riboswitch. Angew.Chem.Int.Ed.Engl., 55, 2016
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6MB5
| AAC-IIIb binary with NEOMYCIN | 分子名称: | Aac(3)-IIIb protein, NEOMYCIN | 著者 | Cuneo, M.J, Kumar, P. | 登録日 | 2018-08-29 | 公開日 | 2018-11-07 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Encoding of Promiscuity in an Aminoglycoside Acetyltransferase. J. Med. Chem., 61, 2018
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6MB9
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2FCY
| HIV-1 DIS kissing-loop in complex with Neomycin | 分子名称: | CHLORIDE ION, HIV-1 DIS RNA, NEOMYCIN, ... | 著者 | Ennifar, E, Paillart, J.C, Marquet, R, Dumas, P. | 登録日 | 2005-12-13 | 公開日 | 2006-05-16 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Targeting the dimerization initiation site of HIV-1 RNA with aminoglycosides: from crystal to cell. Nucleic Acids Res., 34, 2006
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2ET4
| Complex Between Neomycin B and the 16S-RRNA A-Site | 分子名称: | 5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3', NEOMYCIN | 著者 | Westhof, E. | 登録日 | 2005-10-27 | 公開日 | 2005-12-13 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structures of complexes between aminoglycosides and decoding A site oligonucleotides: role of the number of rings and positive charges in the specific binding leading to miscoding. Nucleic Acids Res., 33, 2005
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1EI2
| STRUCTURAL BASIS FOR RECOGNITION OF THE RNA MAJOR GROOVE IN THE TAU EXON 10 SPLICING REGULATORY ELEMENT BY AMINOGLYCOSIDE ANTIBIOTICS | 分子名称: | NEOMYCIN, TAU EXON 10 SRE RNA | 著者 | Varani, L, Spillantini, M.G, Goedert, M, Varani, G. | 登録日 | 2000-02-23 | 公開日 | 2000-03-06 | 最終更新日 | 2017-02-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural basis for recognition of the RNA major groove in the tau exon 10 splicing regulatory element by aminoglycoside antibiotics. Nucleic Acids Res., 28, 2000
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6UN8
| Wild type ANT bound to neomycin | 分子名称: | Aminoglycoside NucleotidylTransferase, MAGNESIUM ION, NEOMYCIN | 著者 | Cuneo, M.J, Selvaraj, B. | 登録日 | 2019-10-11 | 公開日 | 2020-05-06 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | "Catch and Release": a Variation of the Archetypal NucleotidylTransfer Reaction ACS Catal, 10, 2020
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7UUN
| Crystal structure of aminoglycoside resistance enzyme ApmA, complex with neomycin | 分子名称: | 1,2-ETHANEDIOL, Aminocyclitol acetyltransferase ApmA, NEOMYCIN | 著者 | Stogios, P.J, Evdokimova, E, Di Leo, R, Osipiuk, J, Bordeleau, E, Wright, G.D, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID), Center for Structural Biology of Infectious Diseases (CSBID) | 登録日 | 2022-04-28 | 公開日 | 2022-11-02 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | 主引用文献 | Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance. Nat.Chem.Biol., 20, 2024
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3C7R
| Crystal Structure of HIV-1 subtype F DIS extended duplex RNA bound to neomycin | 分子名称: | HIV-1 subtype F genomic RNA, NEOMYCIN, POTASSIUM ION | 著者 | Freisz, S, Lang, K, Micura, R, Dumas, P, Ennifar, E. | 登録日 | 2008-02-08 | 公開日 | 2008-05-06 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Binding of aminoglycoside antibiotics to the duplex form of the HIV-1 genomic RNA dimerization initiation site. Angew.Chem.Int.Ed.Engl., 47, 2008
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1ZX7
| Molecular Recognition of RNA by Neomycin and a Restricted Neomycin Derivative | 分子名称: | 5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*AP*CP*C)-3', 5'-R(*GP*UP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*CP*GP*G)-3' | 著者 | Zhao, Q, Zhao, F, Blount, K.F, Han, Q, Tor, Y, Hermann, T. | 登録日 | 2005-06-07 | 公開日 | 2005-09-20 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Molecular recognition of RNA by neomycin and a restricted neomycin derivative Angew.Chem.Int.Ed.Engl., 44, 2005
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5IQE
| Aminoglycoside Phosphotransferase (2'')-Ia (CTD of AAC(6')-Ie/APH(2'')-Ia) in complex with GMPPNP, Magnesium, and Neomycin B | 分子名称: | Bifunctional AAC/APH, GLYCEROL, MAGNESIUM ION, ... | 著者 | Caldwell, S.J, Berghuis, A.M. | 登録日 | 2016-03-10 | 公開日 | 2016-05-25 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Antibiotic Binding Drives Catalytic Activation of Aminoglycoside Kinase APH(2)-Ia. Structure, 24, 2016
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6CBL
| x-ray structure of NeoB from Streptomyces fradiae in complex with neamine as an external aldimine | 分子名称: | (1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2-amino-2,6-dideoxy-6-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]-alpha-D-glucopyranoside, CHLORIDE ION, Neamine transaminase NeoN | 著者 | Thoden, J.B, Dow, G.T, Holden, H.M. | 登録日 | 2018-02-03 | 公開日 | 2018-02-21 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | The three-dimensional structure of NeoB: An aminotransferase involved in the biosynthesis of neomycin. Protein Sci., 27, 2018
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6CBK
| X-ray structure of NeoB from Streptomyces fradiae in complex with PMP | 分子名称: | 1,2-ETHANEDIOL, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, Neamine transaminase NeoN, ... | 著者 | Thoden, J.B, Dow, G.T, Holden, H.M. | 登録日 | 2018-02-03 | 公開日 | 2018-03-07 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | The three-dimensional structure of NeoB: An aminotransferase involved in the biosynthesis of neomycin. Protein Sci., 27, 2018
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