PDB: 498 resultsInfo pagesStatus searchChemie searchBIRD

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4D2S	Human TTK in complex with a Dyrk1B inhibitor Descriptor: DUAL SPECIFICITY PROTEIN KINASE TTK, N-{2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]phenyl}-4-(1H-pyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine Authors: Debreczeni, J.E, Kettle, J.G, Ballard, P, Bardelle, C, Butterworth, S, Colclough, N, Critchlow, S.E, Fairley, G, Fillery, S, Graham, M.A, Goodwin, L, Guichard, S, Hudson, K, Mahmood, A, Vincent, J, Ward, R.A, Whittaker, D. Deposit date: 2014-05-12 Release date: 2015-04-22 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Discovery and Optimization of a Novel Series of Dyrk1B Kinase Inhibitors to Explore a Mek Resistance Hypothesis. J.Med.Chem., 58, 2015
4D2R	Human IGF in complex with a Dyrk1B inhibitor Descriptor: CHLORIDE ION, INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR, N-{2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]phenyl}-4-(1H-pyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine Authors: Debreczeni, J.E, Kettle, J.G, Ballard, P, Bardelle, C, Butterworth, S, Colclough, N, Critchlow, S.E, Fairley, G, Fillery, S, Graham, M.A, Goodwin, L, Guichard, S, Hudson, K, Mahmood, A, Vincent, J, Ward, R.A, Whittaker, D. Deposit date: 2014-05-12 Release date: 2015-04-22 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Discovery and Optimization of a Novel Series of Dyrk1B Kinase Inhibitors to Explore a Mek Resistance Hypothesis. J.Med.Chem., 58, 2015
2YHA	Crystal Structure of the N. crassa QDE-2 AGO MID-PIWI Domains Descriptor: GLYCEROL, POST-TRANSCRIPTIONAL GENE SILENCING PROTEIN QDE-2, SULFATE ION Authors: Boland, A, Weichenrieder, O. Deposit date: 2011-04-27 Release date: 2011-06-15 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Crystal Structure of the Mid-Piwi Lobe of a Eukaryotic Argonaute Protein Proc.Natl.Acad.Sci.USA, 108, 2011
3JB9	Cryo-EM structure of the yeast spliceosome at 3.6 angstrom resolution Descriptor: ADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... Authors: Yan, C, Hang, J, Wan, R, Huang, M, Wong, C, Shi, Y. Deposit date: 2015-08-09 Release date: 2015-09-23 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Structure of a yeast spliceosome at 3.6-angstrom resolution Science, 349, 2015
6QH3	Catalytic domain of the human ubiquitin-conjugating enzyme UBE2S C118M Descriptor: 1,2-ETHANEDIOL, Ubiquitin-conjugating enzyme E2 S Authors: Liess, A.K.L, Lorenz, S. Deposit date: 2019-01-15 Release date: 2019-07-17 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Autoinhibition Mechanism of the Ubiquitin-Conjugating Enzyme UBE2S by Autoubiquitination. Structure, 27, 2019
6QHK	PAO-linked dimer of the catalytic domain of the human ubiquitin-conjugating enzyme UBE2S Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Phenylarsine oxide, ... Authors: Liess, A.K.L, Lorenz, S. Deposit date: 2019-01-16 Release date: 2019-07-17 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.96 Å) Cite: Autoinhibition Mechanism of the Ubiquitin-Conjugating Enzyme UBE2S by Autoubiquitination. Structure, 27, 2019
3VHX	The crystal structure of Arf6-MKLP1 (Mitotic kinesin-like protein 1) complex Descriptor: ADP-ribosylation factor 6, GLYCEROL, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Makyio, H, Takei, T, Ohgi, H, Takahashi, S, Takatsu, H, Ueda, T, Kanaho, Y, Xie, Y, Shin, H.W, Kamikubo, H, Kataoka, M, Kawasaki, M, Kato, R, Wakatsuki, S, Nakayama, K. Deposit date: 2011-09-12 Release date: 2012-05-16 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.81 Å) Cite: Structural basis for Arf6-MKLP1 complex formation on the Flemming body responsible for cytokinesis Embo J., 31, 2012
2YHB	Crystal Structure of the N. crassa QDE-2 AGO MID-PIWI Domains Descriptor: GLYCEROL, POST-TRANSCRIPTIONAL GENE SILENCING PROTEIN QDE-2, SULFATE ION Authors: Boland, A, Weichenrieder, O. Deposit date: 2011-04-27 Release date: 2011-06-15 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (3.65 Å) Cite: Crystal Structure of the Mid-Piwi Lobe of a Eukaryotic Argonaute Protein Proc.Natl.Acad.Sci.USA, 108, 2011
3FL6	Influence of the incorporation of a cyclohexenyl nucleic acid (CeNA) residue onto the sequence d(GCGTGCG)/d(CGCACGC) Descriptor: 5'-D(*CP*GP*CP*AP*CP*GP*C)-3', 5'-D(*GP*CP*GP*(XTR)P*GP*CP*G)-3', COBALT HEXAMMINE(III) Authors: Robeyns, K, Herdewijn, P, Van Meervelt, L. Deposit date: 2008-12-18 Release date: 2009-12-29 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.17 Å) Cite: Direct observation of two cyclohexenyl (CeNA) ring conformations in duplex DNA. Artif DNA PNA XNA, 1, 2010
4E8U	Crystal structure of Arabidopsis IDN2 XS domain along with a small segment of adjacent coiled-coil region Descriptor: Putative uncharacterized protein T8P19.180, SULFATE ION Authors: Simanshu, D.K, Patel, D.J. Deposit date: 2012-03-20 Release date: 2012-06-06 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.701 Å) Cite: INVOLVED IN DE NOVO 2-containing complex involved in RNA-directed DNA methylation in Arabidopsis. Proc.Natl.Acad.Sci.USA, 109, 2012
6S2W	Structure of S. pombe Erh1, a protein important for meiotic mRNA decay in mitosis and meiosis progression. Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETIC ACID, ... Authors: Hazra, D, Graille, M. Deposit date: 2019-06-22 Release date: 2020-02-12 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Formation of S. pombe Erh1 homodimer mediates gametogenic gene silencing and meiosis progression. Sci Rep, 10, 2020
3N3W	2.2 Angstrom Resolution Crystal Structure of Nuclease Domain of Ribonuclase III (rnc) from Campylobacter jejuni Descriptor: Ribonuclease III Authors: Minasov, G, Halavaty, A, Shuvalova, L, Dubrovska, I, Winsor, J, Papazisi, L, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) Deposit date: 2010-05-20 Release date: 2010-06-02 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.205 Å) Cite: 2.2 Angstrom Resolution Crystal Structure of Nuclease Domain of Ribonuclase III (rnc) from Campylobacter jejuni TO BE PUBLISHED
3NEW	p38-alpha complexed with Compound 10 Descriptor: 4-(trifluoromethyl)-3-[3-(trifluoromethyl)phenyl]-1,7-dihydro-6H-pyrazolo[3,4-b]pyridin-6-one, Mitogen-activated protein kinase 14 Authors: Goedken, E.R, Comess, K.M, Sun, C, Argiriadi, M, Jia, Y, Quinn, C.M, Banach, D.L, Marcotte, D, Borhani, D. Deposit date: 2010-06-09 Release date: 2010-12-01 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.51 Å) Cite: Discovery and Characterization of Non-ATP Site Inhibitors of the Mitogen Activated Protein (MAP) Kinases. Acs Chem.Biol., 6, 2011
3H0G	RNA Polymerase II from Schizosaccharomyces pombe Descriptor: DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, DNA-directed RNA polymerase II subunit RPB3, ... Authors: Spahr, H, Calero, G, Bushnell, D.A, Kornberg, R.D. Deposit date: 2009-04-09 Release date: 2009-08-25 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (3.65 Å) Cite: Schizosacharomyces pombe RNA polymerase II at 3.6-A resolution. Proc.Natl.Acad.Sci.USA, 106, 2009
3O3I	Crystal Structure of human Hiwi1 PAZ domain (residues 277-399) in complex with 14-mer RNA (12-bp + 2-nt overhang) containing 2'-OH at its 3'-end Descriptor: Piwi-like protein 1, RNA (5'-R(*GP*CP*GP*AP*AP*UP*AP*UP*UP*CP*GP*CP*UP*U)-3') Authors: Tian, Y, Simanshu, D.K, Ma, J.-B, Patel, D.J. Deposit date: 2010-07-24 Release date: 2011-01-12 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.801 Å) Cite: Inaugural Article: Structural basis for piRNA 2'-O-methylated 3'-end recognition by Piwi PAZ (Piwi/Argonaute/Zwille) domains. Proc.Natl.Acad.Sci.USA, 108, 2011
3O7X	Crystal structure of human Hili PAZ domain Descriptor: Piwi-like protein 2 Authors: Tian, Y, Simanshu, D.K, Ma, J.-B, Patel, D.J. Deposit date: 2010-08-01 Release date: 2011-01-12 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.9248 Å) Cite: Inaugural Article: Structural basis for piRNA 2'-O-methylated 3'-end recognition by Piwi PAZ (Piwi/Argonaute/Zwille) domains. Proc.Natl.Acad.Sci.USA, 108, 2011
8E9A	Crystal structure of AsfvPolX in complex with 10-23 DNAzyme and Mg Descriptor: DNA/RNA (52-MER), MAGNESIUM ION, Repair DNA polymerase X, ... Authors: Cramer, E.R, Robart, A.R, Kaya, A.I. Deposit date: 2022-08-26 Release date: 2023-06-21 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.69 Å) Cite: Structure of a 10-23 deoxyribozyme exhibiting a homodimer conformation. Commun Chem, 6, 2023
2QVW	Structure of Giardia Dicer refined against twinned data Descriptor: GLP_546_48378_50642, MANGANESE (II) ION Authors: Doudna, J.A, MacRae, I.J. Deposit date: 2007-08-09 Release date: 2007-09-25 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (3 Å) Cite: An unusual case of pseudo-merohedral twinning in orthorhombic crystals of Dicer Acta Crystallogr.,Sect.D, 63, 2007
2QFA	Crystal structure of a Survivin-Borealin-INCENP core complex Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Baculoviral IAP repeat-containing protein 5, Borealin, ... Authors: Jeyaprakash, A.A, Klein, U.R, Lindner, D, Ebert, J, Nigg, E.A, Conti, E. Deposit date: 2007-06-27 Release date: 2007-11-06 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Structure of a Survivin-Borealin-INCENP Core Complex Reveals How Chromosomal Passengers Travel Together. Cell(Cambridge,Mass.), 131, 2007
5LOH	Kinase domain of human Greatwall Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, STAUROSPORINE, ... Authors: Rajasekaran, M.B, Pearl, L.H, Oliver, A.W. Deposit date: 2016-08-09 Release date: 2016-09-07 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3.1 Å) Cite: A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct. Oncotarget, 7, 2016
2RSO	Solution structure of the chromodomain of Swi6 Descriptor: Chromatin-associated protein swi6 Authors: Shimojo, H, Nishimura, Y. Deposit date: 2012-04-18 Release date: 2012-08-29 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Intrinsic nucleic Acid-binding activity of chp1 chromodomain is required for heterochromatic gene silencing Mol.Cell, 47, 2012
2RSN	Solution structure of the chromodomain of Chp1 in complex with H3K9me3 peptide Descriptor: Chromo domain-containing protein 1, peptide from Histone H3 Authors: Shimojo, H, Nishimura, Y. Deposit date: 2012-04-18 Release date: 2012-08-29 Method: SOLUTION NMR Cite: Intrinsic nucleic Acid-binding activity of chp1 chromodomain is required for heterochromatic gene silencing Mol.Cell, 47, 2012
5N53	Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with N-(3-chloro-4-methoxyphenyl) acetamide Descriptor: D-3-phosphoglycerate dehydrogenase, ~{N}-(3-chloranyl-4-methoxy-phenyl)ethanamide Authors: Unterlass, J.E, Basle, A, Blackburn, T.J, Tucker, J, Cano, C, Noble, M.E.M, Curtin, N.J. Deposit date: 2017-02-12 Release date: 2017-04-05 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.48 Å) Cite: Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer. Oncotarget, 9, 2018
1T2R	Structural basis for 3' end recognition of nucleic acids by the Drosophila Argonaute 2 PAZ domain Descriptor: 5'-R(*CP*UP*CP*AP*C)-3', Argonaute 2 Authors: Lingel, A, Simon, B, Izaurralde, E, Sattler, M. Deposit date: 2004-04-22 Release date: 2004-06-01 Last modified: 2022-03-02 Method: SOLUTION NMR Cite: Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain. Nat.Struct.Mol.Biol., 11, 2004
1T2S	Structural basis for 3' end recognition of nucleic acids by the Drosophila Argonaute 2 PAZ domain Descriptor: 5'-D(*CP*TP*CP*AP*C)-3', Argonaute 2 Authors: Lingel, A, Simon, B, Izaurralde, E, Sattler, M. Deposit date: 2004-04-22 Release date: 2004-06-01 Last modified: 2022-03-02 Method: SOLUTION NMR Cite: Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain. Nat.Struct.Mol.Biol., 11, 2004

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