PDB: 542 resultsInfo pagesStatus searchChemie searchBIRD

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1R9F	Crystal structure of p19 complexed with 19-bp small interfering RNA Descriptor: 5'-R(*CP*GP*UP*AP*CP*GP*CP*GP*GP*AP*AP*UP*AP*CP*UP*UP*CP*GP*AP*UP*U)-3', 5'-R(*UP*CP*GP*AP*AP*GP*UP*AP*UP*UP*CP*CP*GP*CP*GP*UP*AP*CP*GP*UP*U)-3', Core protein P19, ... Authors: Ye, K, Malinina, L, Patel, D.J. Deposit date: 2003-10-28 Release date: 2004-01-27 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Recognition of small interfering RNA by a viral suppressor of RNA Nature, 426, 2003
1SI2	Crystal structure of the PAZ domain of human eIF2c1 in complex with a 9-mer siRNA-like duplex of deoxynucleotide overhang Descriptor: 5'-R(*CP*GP*UP*GP*AP*CP*U)-D(P*CP*T)-3', Eukaryotic translation initiation factor 2C 1 Authors: Ye, K, Ma, J.B, Patel, D. Deposit date: 2004-02-26 Release date: 2004-05-25 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain. Nature, 429, 2004
1SI3	Crystal structure of the PAZ domain of human eIF2c1 in complex with a 9-mer siRNA-like duplex Descriptor: 5'-R(*CP*GP*UP*GP*AP*CP*UP*CP*U)-3', Eukaryotic translation initiation factor 2C 1 Authors: Ye, K, Ma, J.B, Patel, D. Deposit date: 2004-02-27 Release date: 2004-05-25 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain. Nature, 429, 2004
8SKQ	RNA oligonucleotide containing an alpha-(L)-threofuranosyl nucleic acid (TNA) Descriptor: TNA-containing RNA oligonucleotide Authors: Harp, J.M, Egli, M. Deposit date: 2023-04-20 Release date: 2024-02-14 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Shorter Is Better: The alpha-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs. J.Am.Chem.Soc., 145, 2023
7W82	Crystal structure of maize RDR2 Descriptor: RNA-dependent RNA polymerase Authors: Du, X, Yang, Z, Du, J. Deposit date: 2021-12-07 Release date: 2022-06-08 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Structure of plant RNA-DEPENDENT RNA POLYMERASE 2, an enzyme involved in small interfering RNA production. Plant Cell, 34, 2022
7W88	CryoEM structure of open form ZmRDR2 at 3.5 Angstroms resolution Descriptor: RNA-dependent RNA polymerase Authors: Du, X, Yang, Z, Du, J. Deposit date: 2021-12-07 Release date: 2022-06-08 Last modified: 2025-07-02 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Structure of plant RNA-DEPENDENT RNA POLYMERASE 2, an enzyme involved in small interfering RNA production. Plant Cell, 34, 2022
7W84	CryoEM structure of apo form ZmRDR2 at 3.4 Angstroms resolution Descriptor: RNA-dependent RNA polymerase Authors: Du, X, Yang, Z, Du, J. Deposit date: 2021-12-07 Release date: 2022-06-08 Last modified: 2025-07-02 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structure of plant RNA-DEPENDENT RNA POLYMERASE 2, an enzyme involved in small interfering RNA production. Plant Cell, 34, 2022
4J1V	Functional and structural studies of MOBKL1B, a Salvador/Warts/Hippo tumor suppressor pathway, in HCV replication Descriptor: MOB kinase activator 1A, NS5A domain II peptide, ZINC ION Authors: Chung, H.-Y, Gu, M, Rice, C.M. Deposit date: 2013-02-02 Release date: 2014-08-06 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Seed Sequence-Matched Controls Reveal Limitations of Small Interfering RNA Knockdown in Functional and Structural Studies of Hepatitis C Virus NS5A-MOBKL1B Interaction. J.Virol., 88, 2014
8THQ	Nonamer RNA bound to hAgo2-PAZ Descriptor: Protein argonaute-2, RNA (5'-R(*CP*GP*UP*GP*AP*CP*UP*CP*U)-3') Authors: Pallan, P.S, Harp, J.M, Egli, M. Deposit date: 2023-07-17 Release date: 2024-10-16 Method: X-RAY DIFFRACTION (2.41 Å) Cite: Single-Stranded Hairpin Loop RNAs (loopmeRNAs) Potently Induce Gene Silencing through the RNA Interference Pathway. J.Am.Chem.Soc., 2024
5NPA	Solution structure of Drosophila melanogaster Loquacious dsRBD2 Descriptor: Loquacious Authors: Tants, J.-N, Fesser, S, Kern, T, Stehle, R, Geerlof, A, Wunderlich, C, Boettcher, R, Kunzelmann, S, Lange, O, Kreutz, C, Foerstemann, K, Sattler, M. Deposit date: 2017-04-16 Release date: 2017-10-04 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Molecular basis for asymmetry sensing of siRNAs by the Drosophila Loqs-PD/Dcr-2 complex in RNA interference. Nucleic Acids Res., 45, 2017
5NPG	Solution structure of Drosophila melanogaster Loquacious dsRBD1 Descriptor: Loquacious, isoform F Authors: Tants, J.-N, Fesser, S, Kern, T, Stehle, R, Geerlof, A, Wunderlich, C, Hartlmuller, C, Boettcher, R, Kunzelmann, S, Lange, O, Kreutz, C, Foerstemann, K, Sattler, M. Deposit date: 2017-04-16 Release date: 2017-10-04 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Molecular basis for asymmetry sensing of siRNAs by the Drosophila Loqs-PD/Dcr-2 complex in RNA interference. Nucleic Acids Res., 45, 2017
5JS2	Human Argonaute-2 Bound to a Modified siRNA Descriptor: MAGNESIUM ION, PHENOL, PHOSPHATE ION, ... Authors: Schirle, N.T, MacRae, I.J. Deposit date: 2016-05-07 Release date: 2016-07-20 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.954 Å) Cite: Structural Analysis of Human Argonaute-2 Bound to a Modified siRNA Guide. J.Am.Chem.Soc., 138, 2016
5JS1	Human Argonaute2 Bound to an siRNA Descriptor: MAGNESIUM ION, PHENOL, Protein argonaute-2, ... Authors: Schirle, N.T, MacRae, I.J. Deposit date: 2016-05-07 Release date: 2016-07-20 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.499 Å) Cite: Structural Analysis of Human Argonaute-2 Bound to a Modified siRNA Guide. J.Am.Chem.Soc., 138, 2016
3G80	Nodamura virus protein b2, RNA-binding domain Descriptor: Protein B2 Authors: Korber, S, Shaik Syed Ali, P, Chen, J.C. Deposit date: 2009-02-11 Release date: 2010-01-05 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structure of the RNA-Binding Domain of Nodamura Virus Protein B2, a Suppressor of RNA Interference. Biochemistry, 48, 2009
2B9Z	Solution structure of FHV B2, a viral suppressor of RNAi Descriptor: B2 protein Authors: Lingel, A, Simon, B, Izaurralde, E, Sattler, M. Deposit date: 2005-10-13 Release date: 2005-11-29 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: The structure of the flock house virus B2 protein, a viral suppressor of RNA interference, shows a novel mode of double-stranded RNA recognition. Embo Rep., 6, 2005
3BDL	Crystal structure of a truncated human Tudor-SN Descriptor: CITRIC ACID, Staphylococcal nuclease domain-containing protein 1 Authors: Li, C.L. Deposit date: 2007-11-15 Release date: 2008-08-26 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural and functional insights into human Tudor-SN, a key component linking RNA interference and editing. Nucleic Acids Res., 36, 2008
2BGG	The structure of a Piwi protein from Archaeoglobus fulgidus complexed with a 16nt siRNA duplex. Descriptor: 5'-R(*GP*UP*CP*GP*AP*AP*UP*UP)-3', 5'-R(*UP*UP*CP*GP*AP*CP*GP*CP)-3', MANGANESE (II) ION, ... Authors: Parker, J.S, Roe, S.M, Barford, D. Deposit date: 2004-12-22 Release date: 2005-03-31 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural Insights Into Mrna Recognition from a Piwi Domain-Sirna Guide Complex Nature, 434, 2005
9KAY	Bioengineered protein nanocarrier facilitating siRNA escape from lysosomes for targeted RNAi therapy in glioblastoma Descriptor: Ferritin heavy chain, N-terminally processed Authors: Chen, X, Fan, K. Deposit date: 2024-10-30 Release date: 2025-03-12 Method: ELECTRON MICROSCOPY (1.73 Å) Cite: Bioengineered protein nanocarrier facilitating siRNA escape from lysosomes for targeted RNAi therapy in glioblastoma. Sci Adv, 11, 2025
7C6B	Crystal structure of Ago2 MID domain in complex with 6-(3-(2-carboxyethyl)phenyl)purine riboside monophosphate Descriptor: 3-[3-[9-[(2R,3R,4S,5R)-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]purin-6-yl]phenyl]propanoic acid, PHOSPHATE ION, Protein argonaute-2 Authors: Suzuki, M, Takahashi, Y, Saito, J, Miyagi, H, Shinohara, F. Deposit date: 2020-05-21 Release date: 2020-11-25 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.7 Å) Cite: siRNA potency enhancement via chemical modifications of nucleotide bases at the 5'-end of the siRNA guide strand. Rna, 27, 2021
7D7U	Crystal structure of Ago2 MID domain in complex with 8-Br-adenosin-5'-monophosphate Descriptor: 8-BROMO-ADENOSINE-5'-MONOPHOSPHATE, Protein argonaute-2 Authors: Suzuki, M, Takahashi, Y, Saito, J, Miyagi, H, Shinohara, F. Deposit date: 2020-10-06 Release date: 2020-11-25 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2 Å) Cite: siRNA potency enhancement via chemical modifications of nucleotide bases at the 5'-end of the siRNA guide strand. Rna, 27, 2021
9K6Q	"Cryo-EM Structure of hAGO2D669A-siRNA-target (14-nt, sesqui-lobed) Descriptor: MAGNESIUM ION, Protein argonaute-2, RNA (5'-R(P*GP*AP*AP*AP*GP*GP*CP*UP*CP*UP*UP*GP*U)-3'), ... Authors: Li, Z.Z, Xu, Q.K, Wu, J.P, Shen, E.Z. Deposit date: 2024-10-22 Release date: 2025-06-25 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Mechanistic insights into RNA cleavage by human Argonaute2-siRNA complex. Cell Res., 35, 2025
9K6R	Cryo-EM Structure of hAGO2D669A-siRNA-target (14-nt, uni-lobed) Descriptor: MAGNESIUM ION, Protein argonaute-2, RNA (5'-R(P*GP*AP*AP*AP*GP*GP*CP*UP*CP*UP*UP*GP*UP*U)-3'), ... Authors: Li, Z.Z, Xu, Q.K, Wu, J.P, Shen, E.Z. Deposit date: 2024-10-22 Release date: 2025-06-25 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Mechanistic insights into RNA cleavage by human Argonaute2-siRNA complex. Cell Res., 35, 2025
9K6T	Cryo-EM Structure of hAGO2D669A-siRNA-target (21-nt) Descriptor: MAGNESIUM ION, Protein argonaute-2, RNA (5'-R(P*AP*AP*CP*AP*AP*CP*AP*GP*AP*AP*AP*GP*GP*CP*UP*CP*UP*UP*GP*UP*U)-3'), ... Authors: Li, Z.Z, Xu, Q.K, Wu, J.P, Shen, E.Z. Deposit date: 2024-10-22 Release date: 2025-06-25 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Mechanistic insights into RNA cleavage by human Argonaute2-siRNA complex. Cell Res., 35, 2025
9K6P	Cryo-EM Structure of hAGO2D669A-siRNA-target (12-nt) Descriptor: Protein argonaute-2, RNA (5'-R(P*GP*GP*CP*UP*CP*UP*UP*GP*U)-3'), RNA (5'-R(P*UP*AP*CP*AP*AP*GP*AP*GP*CP*C)-3') Authors: Li, Z.Z, Xu, Q.K, Wu, J.P, Shen, E.Z. Deposit date: 2024-10-22 Release date: 2025-06-25 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Mechanistic insights into RNA cleavage by human Argonaute2-siRNA complex. Cell Res., 35, 2025
9K6S	Cryo-EM Structure of hAGO2D669A-siRNA-target (19-nt) Descriptor: MAGNESIUM ION, Protein argonaute-2, RNA (5'-R(P*CP*AP*AP*CP*AP*GP*AP*AP*AP*GP*GP*CP*UP*CP*UP*UP*GP*UP*U)-3'), ... Authors: Li, Z.Z, Xu, Q.K, Wu, J.P, Shen, E.Z. Deposit date: 2024-10-22 Release date: 2025-06-25 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Mechanistic insights into RNA cleavage by human Argonaute2-siRNA complex. Cell Res., 35, 2025

 

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