1R9F
| Crystal structure of p19 complexed with 19-bp small interfering RNA | Descriptor: | 5'-R(*CP*GP*UP*AP*CP*GP*CP*GP*GP*AP*AP*UP*AP*CP*UP*UP*CP*GP*AP*UP*U)-3', 5'-R(*UP*CP*GP*AP*AP*GP*UP*AP*UP*UP*CP*CP*GP*CP*GP*UP*AP*CP*GP*UP*U)-3', Core protein P19, ... | Authors: | Ye, K, Malinina, L, Patel, D.J. | Deposit date: | 2003-10-28 | Release date: | 2004-01-27 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Recognition of small interfering RNA by a viral suppressor of RNA Nature, 426, 2003
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1SI2
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1SI3
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8SKQ
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7W84
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7W88
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7W82
| Crystal structure of maize RDR2 | Descriptor: | RNA-dependent RNA polymerase | Authors: | Du, X, Yang, Z, Du, J. | Deposit date: | 2021-12-07 | Release date: | 2022-06-08 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structure of plant RNA-DEPENDENT RNA POLYMERASE 2, an enzyme involved in small interfering RNA production. Plant Cell, 34, 2022
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4J1V
| Functional and structural studies of MOBKL1B, a Salvador/Warts/Hippo tumor suppressor pathway, in HCV replication | Descriptor: | MOB kinase activator 1A, NS5A domain II peptide, ZINC ION | Authors: | Chung, H.-Y, Gu, M, Rice, C.M. | Deposit date: | 2013-02-02 | Release date: | 2014-08-06 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Seed Sequence-Matched Controls Reveal Limitations of Small Interfering RNA Knockdown in Functional and Structural Studies of Hepatitis C Virus NS5A-MOBKL1B Interaction. J.Virol., 88, 2014
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5NPA
| Solution structure of Drosophila melanogaster Loquacious dsRBD2 | Descriptor: | Loquacious | Authors: | Tants, J.-N, Fesser, S, Kern, T, Stehle, R, Geerlof, A, Wunderlich, C, Boettcher, R, Kunzelmann, S, Lange, O, Kreutz, C, Foerstemann, K, Sattler, M. | Deposit date: | 2017-04-16 | Release date: | 2017-10-04 | Last modified: | 2019-05-08 | Method: | SOLUTION NMR | Cite: | Molecular basis for asymmetry sensing of siRNAs by the Drosophila Loqs-PD/Dcr-2 complex in RNA interference. Nucleic Acids Res., 45, 2017
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5NPG
| Solution structure of Drosophila melanogaster Loquacious dsRBD1 | Descriptor: | Loquacious, isoform F | Authors: | Tants, J.-N, Fesser, S, Kern, T, Stehle, R, Geerlof, A, Wunderlich, C, Hartlmuller, C, Boettcher, R, Kunzelmann, S, Lange, O, Kreutz, C, Foerstemann, K, Sattler, M. | Deposit date: | 2017-04-16 | Release date: | 2017-10-04 | Last modified: | 2019-05-08 | Method: | SOLUTION NMR | Cite: | Molecular basis for asymmetry sensing of siRNAs by the Drosophila Loqs-PD/Dcr-2 complex in RNA interference. Nucleic Acids Res., 45, 2017
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5JS2
| Human Argonaute-2 Bound to a Modified siRNA | Descriptor: | MAGNESIUM ION, PHENOL, PHOSPHATE ION, ... | Authors: | Schirle, N.T, MacRae, I.J. | Deposit date: | 2016-05-07 | Release date: | 2016-07-20 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.954 Å) | Cite: | Structural Analysis of Human Argonaute-2 Bound to a Modified siRNA Guide. J.Am.Chem.Soc., 138, 2016
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5JS1
| Human Argonaute2 Bound to an siRNA | Descriptor: | MAGNESIUM ION, PHENOL, Protein argonaute-2, ... | Authors: | Schirle, N.T, MacRae, I.J. | Deposit date: | 2016-05-07 | Release date: | 2016-07-20 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.499 Å) | Cite: | Structural Analysis of Human Argonaute-2 Bound to a Modified siRNA Guide. J.Am.Chem.Soc., 138, 2016
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3G80
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2B9Z
| Solution structure of FHV B2, a viral suppressor of RNAi | Descriptor: | B2 protein | Authors: | Lingel, A, Simon, B, Izaurralde, E, Sattler, M. | Deposit date: | 2005-10-13 | Release date: | 2005-11-29 | Last modified: | 2022-03-09 | Method: | SOLUTION NMR | Cite: | The structure of the flock house virus B2 protein, a viral suppressor of RNA interference, shows a novel mode of double-stranded RNA recognition. Embo Rep., 6, 2005
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3BDL
| Crystal structure of a truncated human Tudor-SN | Descriptor: | CITRIC ACID, Staphylococcal nuclease domain-containing protein 1 | Authors: | Li, C.L. | Deposit date: | 2007-11-15 | Release date: | 2008-08-26 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural and functional insights into human Tudor-SN, a key component linking RNA interference and editing. Nucleic Acids Res., 36, 2008
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2BGG
| The structure of a Piwi protein from Archaeoglobus fulgidus complexed with a 16nt siRNA duplex. | Descriptor: | 5'-R(*GP*UP*CP*GP*AP*AP*UP*UP)-3', 5'-R(*UP*UP*CP*GP*AP*CP*GP*CP)-3', MANGANESE (II) ION, ... | Authors: | Parker, J.S, Roe, S.M, Barford, D. | Deposit date: | 2004-12-22 | Release date: | 2005-03-31 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural Insights Into Mrna Recognition from a Piwi Domain-Sirna Guide Complex Nature, 434, 2005
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7C6B
| Crystal structure of Ago2 MID domain in complex with 6-(3-(2-carboxyethyl)phenyl)purine riboside monophosphate | Descriptor: | 3-[3-[9-[(2R,3R,4S,5R)-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]purin-6-yl]phenyl]propanoic acid, PHOSPHATE ION, Protein argonaute-2 | Authors: | Suzuki, M, Takahashi, Y, Saito, J, Miyagi, H, Shinohara, F. | Deposit date: | 2020-05-21 | Release date: | 2020-11-25 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | siRNA potency enhancement via chemical modifications of nucleotide bases at the 5'-end of the siRNA guide strand. Rna, 27, 2021
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7D7U
| Crystal structure of Ago2 MID domain in complex with 8-Br-adenosin-5'-monophosphate | Descriptor: | 8-BROMO-ADENOSINE-5'-MONOPHOSPHATE, Protein argonaute-2 | Authors: | Suzuki, M, Takahashi, Y, Saito, J, Miyagi, H, Shinohara, F. | Deposit date: | 2020-10-06 | Release date: | 2020-11-25 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | siRNA potency enhancement via chemical modifications of nucleotide bases at the 5'-end of the siRNA guide strand. Rna, 27, 2021
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2F8S
| Crystal structure of Aa-Ago with externally-bound siRNA | Descriptor: | 5'-R(P*AP*GP*AP*CP*AP*GP*CP*AP*UP*AP*UP*AP*UP*GP*CP*UP*GP*UP*CP*UP*UP*U)-3', Argonaute protein | Authors: | Yuan, Y.R, Chen, H.Y, Patel, D.J. | Deposit date: | 2005-12-03 | Release date: | 2006-10-31 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | A Potential Protein-RNA Recognition Event along the RISC-Loading Pathway from the Structure of A. aeolicus Argonaute with Externally Bound siRNA. Structure, 14, 2006
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2F8T
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1RPU
| Crystal Structure of CIRV p19 bound to siRNA | Descriptor: | 19 kDa protein, 5'-R(P*CP*GP*UP*AP*CP*GP*CP*GP*UP*CP*AP*CP*GP*CP*GP*UP*AP*CP*GP*UP*U)-3' | Authors: | Vargason, J.M, Szittya, G, Burgyan, J, Hall, T.M.T. | Deposit date: | 2003-12-03 | Release date: | 2004-01-13 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Size selective recognition of siRNA by an RNA silencing suppressor Cell(Cambridge,Mass.), 115, 2003
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6RA4
| Human ARGONAUTE-2 PAZ DOMAIN (214-347) IN COMPLEX WITH CGUGACUCU | Descriptor: | GLYCEROL, Protein argonaute-2, RNA (5'-R(*CP*GP*UP*GP*AP*CP*UP*CP*U)-3') | Authors: | Rondeau, J.-M, Bourgier, E. | Deposit date: | 2019-04-05 | Release date: | 2019-05-08 | Last modified: | 2019-06-05 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | How to Computationally Stack the Deck for Hit-to-Lead Generation: In Silico Molecular Interaction Energy Profiling for de Novo siRNA Guide Strand Surrogate Selection. J.Chem.Inf.Model., 59, 2019
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6VEM
| Structure of RNA octamer | Descriptor: | COBALT HEXAMMINE(III), Modified Octamer RNA | Authors: | Pallan, P.S, Egli, M. | Deposit date: | 2020-01-02 | Release date: | 2020-11-18 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Synthesis, chirality-dependent conformational and biological properties of siRNAs containing 5'-(R)- and 5'-(S)-C-methyl-guanosine. Nucleic Acids Res., 48, 2020
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7VG3
| Cryo-EM structure of Arabidopsis DCL3 in complex with a 30-bp RNA | Descriptor: | CALCIUM ION, Dicer-like 3, TAS1a RNA forward strand (5'-phosphorylated), ... | Authors: | Wang, Q, Du, J. | Deposit date: | 2021-09-14 | Release date: | 2021-10-27 | Last modified: | 2021-12-15 | Method: | ELECTRON MICROSCOPY (3.73 Å) | Cite: | Mechanism of siRNA production by a plant Dicer-RNA complex in dicing-competent conformation. Science, 374, 2021
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7VG2
| Cryo-EM structure of Arabidopsis DCL3 in complex with a 40-bp RNA | Descriptor: | CALCIUM ION, Dicer-like 3, TAS1a forward strand (5'-phosphorylation), ... | Authors: | Wang, Q, Du, J. | Deposit date: | 2021-09-14 | Release date: | 2021-10-27 | Last modified: | 2021-12-15 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Mechanism of siRNA production by a plant Dicer-RNA complex in dicing-competent conformation. Science, 374, 2021
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