7C6B
Crystal structure of Ago2 MID domain in complex with 6-(3-(2-carboxyethyl)phenyl)purine riboside monophosphate
Summary for 7C6B
Entry DOI | 10.2210/pdb7c6b/pdb |
Related | 6L45 |
Descriptor | Protein argonaute-2, 3-[3-[9-[(2R,3R,4S,5R)-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]purin-6-yl]phenyl]propanoic acid, PHOSPHATE ION, ... (4 entities in total) |
Functional Keywords | argonaute, mid domain, ribonucleoprotein, rna-binding, rna-mediated gene silencing, translation regulation, rna binding protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 3 |
Total formula weight | 48026.62 |
Authors | Suzuki, M.,Takahashi, Y.,Saito, J.,Miyagi, H.,Shinohara, F. (deposition date: 2020-05-21, release date: 2020-11-25, Last modification date: 2023-11-29) |
Primary citation | Shinohara, F.,Oashi, T.,Harumoto, T.,Nishikawa, T.,Takayama, Y.,Miyagi, H.,Takahashi, Y.,Nakajima, T.,Sawada, T.,Koda, Y.,Makino, A.,Sato, A.,Hamaguchi, K.,Suzuki, M.,Yamamoto, J.,Tomari, Y.,Saito, J.I. siRNA potency enhancement via chemical modifications of nucleotide bases at the 5'-end of the siRNA guide strand. Rna, 27:163-173, 2021 Cited by PubMed: 33177188DOI: 10.1261/rna.073783.119 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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