PDB: 46006 resultsInfo pagesStatus searchChemie searchBIRD

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8ETU	Class2 of the INO80-Hexasome complex Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin-related protein 5, Chromatin-remodeling ATPase INO80, ... Authors: Wu, H, Munoz, E, Gourdet, M, Cheng, Y.F, Narlikar, G. Deposit date: 2022-10-17 Release date: 2023-07-19 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Reorientation of INO80 on hexasomes reveals basis for mechanistic versatility. Science, 381, 2023
8ETW	Class3 of INO80-Hexasome complex Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin-related protein 5, Chromatin-remodeling ATPase INO80, ... Authors: Wu, H, Munoz, E, Gourdet, M, Narlikar, G, Cheng, Y.F. Deposit date: 2022-10-17 Release date: 2023-07-19 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (2.64 Å) Cite: Reorientation of INO80 on hexasomes reveals basis for mechanistic versatility. Science, 381, 2023
3VB2	Crystal Structure of the Reduced Form of MarR from E.coli Descriptor: Multiple antibiotic resistance protein marR Authors: Lou, H, Zhu, R, Hao, Z. Deposit date: 2011-12-30 Release date: 2013-01-30 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.6 Å) Cite: The reduced form of MarR structure To be Published
7NUF	Vaccinia virus protein 018 in complex with STAT1 Descriptor: ACETYL GROUP, SULFATE ION, Signal transducer and activator of transcription 1-alpha/beta, ... Authors: Pantelejevs, T, Talbot-Cooper, C, Smith, G.L, Hyvonen, M. Deposit date: 2021-03-12 Release date: 2021-07-28 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.0004015 Å) Cite: Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 antagonism to inhibit interferon signaling. Cell Host Microbe, 30, 2022
2GVR	Crystal structure of the berenil-D(CGCGAATTCGCG)2 complex at 1.65 A resolution. Descriptor: 5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3', BERENIL, MAGNESIUM ION Authors: Lee, M.P.H, Parkinson, G.N, Neidle, S. Deposit date: 2006-05-03 Release date: 2007-06-19 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Crystal structure of the berenil-D(CGCGAATTCGCG)2 complex at 1.65 A resolution. To be Published
7F5S	human delta-METTL18 60S ribosome Descriptor: 28S rRNA, 5.8S rRNA, 5S rRNA, ... Authors: Takahashi, M, Kashiwagi, K, Ito, T. Deposit date: 2021-06-22 Release date: 2022-06-22 Method: ELECTRON MICROSCOPY (2.72 Å) Cite: METTL18-mediated histidine methylation of RPL3 modulates translation elongation for proteostasis maintenance. Elife, 11, 2022
2CJJ	Crystal Structure of the MYB domain of the RAD transcription factor from Antirrhinum majus Descriptor: RADIALIS Authors: Stevenson, C.E.M, Burton, N, Costa, M.M, Nath, U, Dixon, R.A, Coen, E.S, Lawson, D.M. Deposit date: 2006-04-04 Release date: 2006-10-25 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal Structure of the Myb Domain of the Rad Transcription Factor from Antirrhinum Majus. Proteins: Struct., Funct., Bioinf., 65, 2006
4FO0	Human actin-related protein Arp8 in its ATP-bound state Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Actin-related protein 8, CHLORIDE ION, ... Authors: Gerhold, C.B, Lakomek, K, Seifert, F.U, Hopfner, K.-P. Deposit date: 2012-06-20 Release date: 2012-09-26 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structure of Actin-related protein 8 and its contribution to nucleosome binding. Nucleic Acids Res., 40, 2012
4QP1	Crystal structure of ERK2 in complex with N-cyclohexyl-9H-purin-6-amine Descriptor: IMIDAZOLE, Mitogen-activated protein kinase 1, N-BENZYL-9H-PURIN-6-AMINE Authors: Yin, J, Wang, W. Deposit date: 2014-06-22 Release date: 2015-09-23 Last modified: 2015-12-16 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
4QP9	Crystal Structure of ERK2 in complex with 7-(1-propyl-1H-pyrazol-4-yl)-2-(pyridin-4-yl)-5H-pyrrolo[2,3-b]pyrazine Descriptor: 7-(1-propyl-1H-pyrazol-4-yl)-2-(pyridin-4-yl)-5H-pyrrolo[2,3-b]pyrazine, Mitogen-activated protein kinase 1 Authors: Yin, J, Wang, W. Deposit date: 2014-06-22 Release date: 2015-09-23 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.001 Å) Cite: Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
5F64	Putative positive transcription regulator (sensor EvgS) from Shigella flexneri Descriptor: Positive transcription regulator EvgA Authors: Nocek, B, Osipiuk, J, Mulligan, R, Gu, M, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) Deposit date: 2015-12-05 Release date: 2015-12-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.71 Å) Cite: Putative positive transcription regulator (sensor EvgS) from Shigella flexneri. to be published
5F6F	S. aureus MepR G34R Mutant Descriptor: MarR family regulatory protein Authors: Newman, C.E, Birukou, I, Brennan, R.G. Deposit date: 2015-12-05 Release date: 2016-12-07 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.751 Å) Cite: S. aureus MepR G34R Mutant To Be Published
4QP7	Crystal Structure of ERK2 in complex with 2-(1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine Descriptor: 2-(1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine, Mitogen-activated protein kinase 1 Authors: Yin, J, Wang, W. Deposit date: 2014-06-22 Release date: 2015-09-23 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.249 Å) Cite: Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
8HWD	Cryo-EM Structure of D5 ADP form Descriptor: ADENOSINE-5'-DIPHOSPHATE, Primase D5 Authors: Li, Y.N, Zhu, J, Guo, Y.Y, Yan, R.H. Deposit date: 2022-12-29 Release date: 2024-01-10 Last modified: 2024-01-31 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Structural insight into the assembly and working mechanism of helicase-primase D5 from Mpox virus. Nat.Struct.Mol.Biol., 31, 2024
8HWE	Cryo-EM Structure of D5 ATP-ADP form Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... Authors: Li, Y.N, Zhu, J, Guo, Y.Y, Yan, R.H. Deposit date: 2022-12-29 Release date: 2024-01-10 Last modified: 2024-01-31 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Structural insight into the assembly and working mechanism of helicase-primase D5 from Mpox virus. Nat.Struct.Mol.Biol., 31, 2024
4QP3	Crystal Structure of ERK2 in complex with (S)-2-((9H-purin-6-yl)amino)-3-phenylpropan-1-ol Descriptor: (2S)-3-phenyl-2-(9H-purin-6-ylamino)propan-1-ol, Mitogen-activated protein kinase 1 Authors: Yin, J, Wang, W. Deposit date: 2014-06-22 Release date: 2015-09-23 Last modified: 2015-12-16 Method: X-RAY DIFFRACTION (2.599 Å) Cite: Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
8HWC	Cryo-EM Structure of D5 Apo Descriptor: Primase D5 Authors: Li, Y.N, Zhu, J, Guo, Y.Y, Yan, R.H. Deposit date: 2022-12-29 Release date: 2024-01-10 Last modified: 2024-01-31 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Structural insight into the assembly and working mechanism of helicase-primase D5 from Mpox virus. Nat.Struct.Mol.Biol., 31, 2024
4QP4	Crystal Structure of ERK2 in complex with N-cyclohexyl-9H-purin-6-amine Descriptor: Mitogen-activated protein kinase 1, N-cyclohexyl-9H-purin-6-amine Authors: Yin, J, Wang, W. Deposit date: 2014-06-22 Release date: 2015-09-23 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
4QC8	Structural annotation of pathogenic bovine Parvovirus-1 Descriptor: VP2 Authors: Kailasan, S, Halder, S, Gurda, B.L, Bladek, H, Chipman, P.R, McKenna, R, Brown, K, Agbandje-McKenna, M. Deposit date: 2014-05-09 Release date: 2015-01-14 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Structure of an enteric pathogen, bovine parvovirus. J.Virol., 89, 2015
4QPA	Crystal Structure of ERK2 in complex with 7-(1-benzyl-1H-pyrazol-4-yl)-2-(pyridin-4-yl)-5H-pyrrolo[2,3-b]pyrazine Descriptor: 7-(1-benzyl-1H-pyrazol-4-yl)-2-(pyridin-4-yl)-5H-pyrrolo[2,3-b]pyrazine, Mitogen-activated protein kinase 1 Authors: Yin, J, Wang, W. Deposit date: 2014-06-22 Release date: 2015-09-23 Last modified: 2015-12-16 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
8D3F	Crystal structure of human STAT1 in complex with the repeat region from Toxoplasma protein TgIST Descriptor: Signal transducer and activator of transcription 1-alpha/beta,Inhibitor of STAT1-dependent transcription TgIST Authors: Huang, Z, Liu, H, Nix, J.C, Amarasinghe, G.K, Sibley, L.D. Deposit date: 2022-06-01 Release date: 2022-07-06 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.97 Å) Cite: The intrinsically disordered protein TgIST from Toxoplasma gondii inhibits STAT1 signaling by blocking cofactor recruitment. Nat Commun, 13, 2022
4QP6	Crystal Structure of ERK2 in complex with 5H-pyrrolo[2,3-b]pyrazine Descriptor: 5H-pyrrolo[2,3-b]pyrazine, IMIDAZOLE, Mitogen-activated protein kinase 1 Authors: Yin, J, Wang, W. Deposit date: 2014-06-22 Release date: 2015-09-23 Last modified: 2015-12-16 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
4QP8	Crystal Structure of ERK2 in complex with 2-(1H-pyrazol-4-yl)-7-(pyridin-3-yl)-5H-pyrrolo[2,3-b]pyrazine Descriptor: 2-(1H-pyrazol-4-yl)-7-(pyridin-3-yl)-5H-pyrrolo[2,3-b]pyrazine, Mitogen-activated protein kinase 1 Authors: Yin, J, Wang, W. Deposit date: 2014-06-22 Release date: 2015-09-23 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.446 Å) Cite: Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
4QP2	Crystal Structure of ERKs in complex with 5-chlorobenzo[d]oxazol-2-amine Descriptor: 5-chloro-1,3-benzoxazol-2-amine, IMIDAZOLE, Mitogen-activated protein kinase 1 Authors: Yin, J, Wang, W. Deposit date: 2014-06-22 Release date: 2015-09-23 Last modified: 2015-12-16 Method: X-RAY DIFFRACTION (2.23 Å) Cite: Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
4QTE	Structure of ERK2 in complex with VTX-11e, 4-{2-[(2-CHLORO-4-FLUOROPHENYL)AMINO]-5-METHYLPYRIMIDIN-4-YL}-N-[(1S)-1-(3-CHLOROPHENYL)-2-HYDROXYETHYL]-1H-PYRROLE-2-CARBOXAMIDE Descriptor: 1,2-ETHANEDIOL, 4-{2-[(2-chloro-4-fluorophenyl)amino]-5-methylpyrimidin-4-yl}-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide, CHLORIDE ION, ... Authors: Chaikuad, A, Savitsky, P, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2014-07-07 Release date: 2014-07-23 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.5 Å) Cite: A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics. Nat.Chem.Biol., 10, 2014

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