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4QP1

Crystal structure of ERK2 in complex with N-cyclohexyl-9H-purin-6-amine

Summary for 4QP1
Entry DOI10.2210/pdb4qp1/pdb
Related4QP2 4QP3 4QP4 4QP6 4QP7 4QP8 4QP9 4QPA
DescriptorMitogen-activated protein kinase 1, N-BENZYL-9H-PURIN-6-AMINE, IMIDAZOLE, ... (4 entities in total)
Functional Keywordskinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm, cytoskeleton, spindle : P28482
Total number of polymer chains2
Total formula weight85844.32
Authors
Yin, J.,Wang, W. (deposition date: 2014-06-22, release date: 2015-09-23, Last modification date: 2015-12-16)
Primary citationBurdick, D.J.,Wang, S.,Heise, C.,Pan, B.,Drummond, J.,Yin, J.,Goeser, L.,Magnuson, S.,Blaney, J.,Moffat, J.,Wang, W.,Chen, H.
Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors.
Bioorg.Med.Chem.Lett., 25:4728-4732, 2015
Cited by
PubMed: 26338362
DOI: 10.1016/j.bmcl.2015.08.048
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.7 Å)
Structure validation

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