4QP8
Crystal Structure of ERK2 in complex with 2-(1H-pyrazol-4-yl)-7-(pyridin-3-yl)-5H-pyrrolo[2,3-b]pyrazine
Summary for 4QP8
Entry DOI | 10.2210/pdb4qp8/pdb |
Related | 4QP1 4QP2 4QP3 4QP4 4QP6 4QP7 4QP9 4QPA |
Descriptor | Mitogen-activated protein kinase 1, 2-(1H-pyrazol-4-yl)-7-(pyridin-3-yl)-5H-pyrrolo[2,3-b]pyrazine (3 entities in total) |
Functional Keywords | kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytoskeleton, spindle : P28482 |
Total number of polymer chains | 2 |
Total formula weight | 85622.25 |
Authors | |
Primary citation | Burdick, D.J.,Wang, S.,Heise, C.,Pan, B.,Drummond, J.,Yin, J.,Goeser, L.,Magnuson, S.,Blaney, J.,Moffat, J.,Wang, W.,Chen, H. Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors. Bioorg.Med.Chem.Lett., 25:4728-4732, 2015 Cited by PubMed: 26338362DOI: 10.1016/j.bmcl.2015.08.048 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.446 Å) |
Structure validation
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