4QP2
Crystal Structure of ERKs in complex with 5-chlorobenzo[d]oxazol-2-amine
Summary for 4QP2
Entry DOI | 10.2210/pdb4qp2/pdb |
Related | 4QP1 4QP3 4QP4 4QP6 4QP7 4QP8 4QP9 4QPA |
Descriptor | Mitogen-activated protein kinase 1, 5-chloro-1,3-benzoxazol-2-amine, IMIDAZOLE, ... (4 entities in total) |
Functional Keywords | kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytoskeleton, spindle : P28482 |
Total number of polymer chains | 2 |
Total formula weight | 85493.32 |
Authors | |
Primary citation | Burdick, D.J.,Wang, S.,Heise, C.,Pan, B.,Drummond, J.,Yin, J.,Goeser, L.,Magnuson, S.,Blaney, J.,Moffat, J.,Wang, W.,Chen, H. Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors. Bioorg.Med.Chem.Lett., 25:4728-4732, 2015 Cited by PubMed: 26338362DOI: 10.1016/j.bmcl.2015.08.048 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.23 Å) |
Structure validation
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